| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
Total
4
Cerebrosterol
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cerebrosterol?
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cerebrosterol
PubChem Associated disorders and diseases
What pathways are associated with Cerebrosterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cerebrosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Cerebrosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Cerebrosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Cerebrosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Cerebrosterol?
Mouse Model
Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Cerebrosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Prasad VV et al. | Identification of 24-hydroxycholesterol in bovine adrenals in both free and esterified forms and in bovine brains as its sulfate ester. | 1984 | J. Steroid Biochem. | pmid:6527537 |
| Saucier SE et al. | Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol. | 1993 | Biochim. Biophys. Acta | pmid:8431485 |
| Lund E et al. | 24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. | 1993 | Biochim. Biophys. Acta | pmid:8443234 |
| Axelson M et al. | Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. | 1995 | J. Lipid Res. | pmid:7751816 |
| Breuer O and Björkhem I | Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. | 1995 | J. Biol. Chem. | pmid:7657597 |
| Lütjohann D et al. | Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8790411 |
| Meng LJ et al. | High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease. | 1997 | J. Lipid Res. | pmid:9186910 |
| Zhang J et al. | Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. | 1997 | Biochem. J. | pmid:9078259 |
| Lehmann JM et al. | Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. | 1997 | J. Biol. Chem. | pmid:9013544 |
| Björkhem I et al. | Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro. | 1997 | J. Biol. Chem. | pmid:9374499 |
| Björkhem I et al. | Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. | 1998 | J. Lipid Res. | pmid:9717719 |
| Babiker A and Diczfalusy U | Transport of side-chain oxidized oxysterols in the human circulation. | 1998 | Biochim. Biophys. Acta | pmid:9630709 |
| Kölsch H et al. | The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. | 1999 | Brain Res. | pmid:9914453 |
| Norlin M et al. | 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). | 2000 | J. Lipid Res. | pmid:11013305 |
| Lütjohann D et al. | Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. | 2000 | J. Lipid Res. | pmid:10681402 |
| Russell DW | Oxysterol biosynthetic enzymes. | 2000 | Biochim. Biophys. Acta | pmid:11111082 |
| Bretillon L et al. | Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. | 2000 | J. Lipid Res. | pmid:10787445 |
| Meaney S et al. | Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique: cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice. | 2000 | Biochim. Biophys. Acta | pmid:10903480 |
| Li-Hawkins J et al. | Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. | 2000 | J. Biol. Chem. | pmid:10748047 |
| Papassotiropoulos A et al. | Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease. | 2000 | Neuroreport | pmid:10884051 |
| Bretillon L et al. | Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases. | 2000 | Neurosci. Lett. | pmid:11027840 |
| Li D and Spencer TA | Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. | 2000 | Steroids | pmid:10978732 |
| Bodin K et al. | Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. | 2001 | J. Biol. Chem. | pmid:11514559 |
| Björkhem I et al. | Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. | 2001 | J. Lipid Res. | pmid:11254748 |
| Bjorkhem I et al. | From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans. | 2001 | J. Biol. Chem. | pmid:11463788 |
| Kölsch H et al. | Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. | 2001 | J Neural Transm | pmid:11475014 |
| Meaney S et al. | Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. | 2001 | J. Lipid Res. | pmid:11160367 |
| Lütjohann D et al. | Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol. | 2001 | Acta Paediatr. | pmid:11440099 |
| Bogdanovic N et al. | On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. | 2001 | Neurosci. Lett. | pmid:11698143 |
| Zhang Z et al. | Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. | 2001 | J. Lipid Res. | pmid:11290837 |
| Kölsch H et al. | Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. | 2002 | Mol. Psychiatry | pmid:12232784 |
| Locatelli S et al. | Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain. | 2002 | Arch. Neurol. | pmid:11843691 |
| Meir K et al. | Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis. | 2002 | J. Biol. Chem. | pmid:12119285 |
| Leoni V et al. | Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis. | 2002 | Neurosci. Lett. | pmid:12383922 |
| Schönknecht P et al. | Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls. | 2002 | Neurosci. Lett. | pmid:11983301 |
| Papassotiropoulos A et al. | 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. | 2002 Jan-Feb | J Psychiatr Res | pmid:11755458 |
| Mast N et al. | Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. | 2003 | Biochemistry | pmid:14640697 |
| Norlin M et al. | On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. | 2003 | J. Lipid Res. | pmid:12777473 |
| Teunissen CE et al. | Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients. | 2003 | Neurosci. Lett. | pmid:12875910 |
| Vega GL et al. | Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease. | 2003 | Arch. Neurol. | pmid:12707064 |
| Kölsch H et al. | The role of 24S-hydroxycholesterol in Alzheimer's disease. | 2003 | J Nutr Health Aging | pmid:12679839 |
| Leoni V et al. | Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. | 2003 | J. Lipid Res. | pmid:12562838 |
| Teunissen CE et al. | Combination of serum markers related to several mechanisms in Alzheimer's disease. | 2003 | Neurobiol. Aging | pmid:12928047 |
| Papassotiropoulos A et al. | Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. | 2003 | Arch. Neurol. | pmid:12533085 |
| Lütjohann D and von Bergmann K | 24S-hydroxycholesterol: a marker of brain cholesterol metabolism. | 2003 | Pharmacopsychiatry | pmid:14574622 |
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| Holdenrieder S et al. | Does brain specific 24S-hydroxycholesterol in plasma indicate the disruption of the blood-brain barrier in patients with ischemic stroke? | 2004 | Neurosci. Lett. | pmid:15351449 |
| Björkhem I and Meaney S | Brain cholesterol: long secret life behind a barrier. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14764421 |
| Kölsch H et al. | Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. | 2004 | Neurosci. Lett. | pmid:15364416 |
| Leoni V et al. | Diagnostic use of cerebral and extracerebral oxysterols. | 2004 | Clin. Chem. Lab. Med. | pmid:15061359 |
| Burkard I et al. | Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. | 2004 | J. Lipid Res. | pmid:14729854 |
| Lütjohann D et al. | High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs. | 2004 | Steroids | pmid:15219793 |
| Brown J et al. | Differential expression of cholesterol hydroxylases in Alzheimer's disease. | 2004 | J. Biol. Chem. | pmid:15148325 |
| Heverin M et al. | Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. | 2004 | J. Lipid Res. | pmid:14523054 |
| Reiss AB et al. | Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease. | 2004 | Neurobiol. Aging | pmid:15212822 |
| Vega GL et al. | The effects of gender and CYP46 and apo E polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients treated with statins. | 2004 | Curr Alzheimer Res | pmid:15975088 |
| Vogelvang TE et al. | Effect of raloxifene and hormone therapy on serum markers of brain and whole-body cholesterol metabolism in postmenopausal women. | 2005 | Maturitas | pmid:15780532 |
| Papassotiropoulos A et al. | A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. | 2005 | J Clin Psychiatry | pmid:16013913 |
| Alexandrov P et al. | 24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells. | 2005 | Neuroreport | pmid:15931060 |
| Teunissen CE et al. | Biological markers in CSF and blood for axonal degeneration in multiple sclerosis. | 2005 | Lancet Neurol | pmid:15620855 |
| Sauder S et al. | Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients. | 2005 | J Neural Transm | pmid:15666037 |
| Sovic A et al. | Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood-brain barrier. | 2005 | J. Neurochem. | pmid:15953354 |
| Kölsch H et al. | Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease. | 2006 | Int. J. Mol. Med. | pmid:16596262 |
| Björkhem I | Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. | 2006 | J. Intern. Med. | pmid:17116000 |
| Lukiw WJ | Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer's disease. | 2006 | Expert Rev Neurother | pmid:16734516 |
| Lütjohann D | Cholesterol metabolism in the brain: importance of 24S-hydroxylation. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866909 |
| Abildayeva K et al. | 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. | 2006 | J. Biol. Chem. | pmid:16524875 |
| Thelen KM et al. | High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. | 2006 | J Clin Pharmacol | pmid:16809807 |
| Panzenboeck U et al. | Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16530456 |
| Solfrizzi V et al. | Circulating biomarkers of cognitive decline and dementia. | 2006 | Clin. Chim. Acta | pmid:16139826 |
| Kölsch H et al. | Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of Alzheimer's disease. | 2006 | J Neural Transm | pmid:15959845 |
| Björkhem I et al. | Oxysterols and Alzheimer's disease. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866910 |
| Karrenbauer VD et al. | Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis. | 2006 | Clin Neurol Neurosurg | pmid:16144738 |
| Thelen KM et al. | Effect of pravastatin on plasma sterols and oxysterols in men. | 2006 | Eur. J. Clin. Pharmacol. | pmid:16385401 |
| He X et al. | Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. | 2006 | J. Neuropathol. Exp. Neurol. | pmid:16825952 |
| Leoni V et al. | Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment? | 2006 Apr 10-17 | Neurosci. Lett. | pmid:16406316 |
| Chen W et al. | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. | 2007 | Cell Metab. | pmid:17189208 |
| Karu K et al. | Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. | 2007 | J. Lipid Res. | pmid:17251593 |
| Fujiyoshi M et al. | 24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression. | 2007 | J. Neurochem. | pmid:17101031 |
| Shafaati M et al. | Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders. | 2007 | Neurosci. Lett. | pmid:17822846 |
| Björkhem I | Rediscovery of cerebrosterol. | 2007 | Lipids | pmid:17393206 |
| Valenza M et al. | Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation. | 2007 | Hum. Mol. Genet. | pmid:17613541 |
| Teunissen CE et al. | 24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis. | 2007 | J. Neurosci. Res. | pmid:17410599 |
| Hansson M et al. | Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. | 2007 | J. Intern. Med. | pmid:17444890 |
| Ohtsuki S et al. | Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier. | 2007 | J. Neurochem. | pmid:17868302 |
| Burkard I et al. | Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. | 2007 | Atherosclerosis | pmid:17107679 |
| Famer D et al. | Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17532301 |
| Joffre C et al. | Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. | 2007 | Curr. Eye Res. | pmid:17453947 |
| Umetani M et al. | 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. | 2007 | Nat. Med. | pmid:17873880 |
| Khripach VA et al. | [A new synthesis of cerebrosterol and its 24-epimer from lithocholic acid]. | 2007 Mar-Apr | Bioorg. Khim. | pmid:17476989 |
| Weiner MF et al. | Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. | 2008 | Brain Inj | pmid:18568715 |
| DeBarber AE et al. | Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol. | 2008 | Anal. Biochem. | pmid:18555788 |
| Wang Y et al. | The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. | 2008 | J. Proteome Res. | pmid:18303831 |
| Bang HJ et al. | A comparison of the potential unfavorable effects of oxycholesterol and oxyphytosterol in mice: different effects, on cerebral 24S-hydroxychoelsterol and serum triacylglycerols levels. | 2008 | Biosci. Biotechnol. Biochem. | pmid:19060413 |
| Rantham Prabhakara JP et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. | 2008 | J. Neurochem. | pmid:19014385 |
| Kristofiková Z et al. | Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers. | 2008 | Neurochem. Res. | pmid:17717740 |
| Leoni V et al. | Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease. | 2008 | Brain | pmid:18772220 |
| Leoni V | Oxysterols as markers of neurological disease--a review. | 2009 | Scand. J. Clin. Lab. Invest. | pmid:19199127 |
| Liao WL et al. | Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry. | 2009 | Biochemistry | pmid:19317426 |