| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
Total
4
Cerebrosterol
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cerebrosterol?
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cerebrosterol
PubChem Associated disorders and diseases
What pathways are associated with Cerebrosterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cerebrosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Cerebrosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Cerebrosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Cerebrosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Cerebrosterol?
Mouse Model
Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Cerebrosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Seet RC et al. | Oxidative damage in ischemic stroke revealed using multiple biomarkers. | 2011 | Stroke | pmid:21700941 |
| Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
| Lütjohann D et al. | High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs. | 2004 | Steroids | pmid:15219793 |
| Vo DK et al. | 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8. | 2015 | Steroids | pmid:25697054 |
| Li D and Spencer TA | Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. | 2000 | Steroids | pmid:10978732 |
| Leoni V | Oxysterols as markers of neurological disease--a review. | 2009 | Scand. J. Clin. Lab. Invest. | pmid:19199127 |
| Zarrouk A et al. | Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity. | 2015 | Rev. Neurol. (Paris) | pmid:25577946 |
| Okabe A et al. | Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death. | 2013 | Redox Biol | pmid:24371802 |
| Zhang J and Liu Q | Cholesterol metabolism and homeostasis in the brain. | 2015 | Protein Cell | pmid:25682154 |
| Lütjohann D et al. | Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8790411 |
| Stiles AR et al. | Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25201972 |
| Soncini M et al. | 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27671648 |
| Testa G et al. | Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. | 2014 | PLoS ONE | pmid:24802026 |
| Sun MY et al. | 24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation. | 2017 | PLoS ONE | pmid:28346482 |
| Acimovic J et al. | Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. | 2013 | PLoS ONE | pmid:23844150 |
| Vanmierlo T et al. | Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. | 2011 | Plant Foods Hum Nutr | pmid:21431910 |
| Lütjohann D and von Bergmann K | 24S-hydroxycholesterol: a marker of brain cholesterol metabolism. | 2003 | Pharmacopsychiatry | pmid:14574622 |
| Ullrich C et al. | Effects of cholesterol and its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices. | 2010 | Pharmacology | pmid:20571288 |
| Zhao S et al. | Polar metabolite of cholesterol induces rat cognitive dysfunctions. | 2009 | Neuroscience | pmid:19699274 |
| Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
| La Marca V et al. | Lecithin-cholesterol acyltransferase in brain: Does oxidative stress influence the 24-hydroxycholesterol esterification? | 2016 | Neurosci. Res. | pmid:26454063 |
| Holdenrieder S et al. | Does brain specific 24S-hydroxycholesterol in plasma indicate the disruption of the blood-brain barrier in patients with ischemic stroke? | 2004 | Neurosci. Lett. | pmid:15351449 |
| Shafaati M et al. | Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders. | 2007 | Neurosci. Lett. | pmid:17822846 |
| Teunissen CE et al. | Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients. | 2003 | Neurosci. Lett. | pmid:12875910 |
| Leoni V et al. | Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis. | 2002 | Neurosci. Lett. | pmid:12383922 |
| Kölsch H et al. | Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. | 2004 | Neurosci. Lett. | pmid:15364416 |
| Bretillon L et al. | Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases. | 2000 | Neurosci. Lett. | pmid:11027840 |
| Leoni V et al. | Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment? | 2006 Apr 10-17 | Neurosci. Lett. | pmid:16406316 |
| Schönknecht P et al. | Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls. | 2002 | Neurosci. Lett. | pmid:11983301 |
| Bogdanovic N et al. | On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. | 2001 | Neurosci. Lett. | pmid:11698143 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Emanuelsson I and Norlin M | Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells. | 2012 | Neurosci. Lett. | pmid:22884615 |
| Björkhem I et al. | Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. | 2013 | Neurosci. Lett. | pmid:24035896 |
| Alexandrov P et al. | 24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells. | 2005 | Neuroreport | pmid:15931060 |
| Papassotiropoulos A et al. | Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease. | 2000 | Neuroreport | pmid:10884051 |
| Linsenbardt AJ et al. | Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. | 2014 | Neuropharmacology | pmid:24878244 |
| Kasimov MR et al. | 24S-Hydroxycholesterol enhances synaptic vesicle cycling in the mouse neuromuscular junction: Implication of glutamate NMDA receptors and nitric oxide. | 2017 | Neuropharmacology | pmid:28153530 |
| Mateos L et al. | side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. | 2012 | Neurodegener Dis | pmid:22236548 |
| Kristofiková Z et al. | Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers. | 2008 | Neurochem. Res. | pmid:17717740 |
| Krištofiková Z et al. | Interactions of amyloid β peptide 1-40 and cerebrosterol. | 2012 | Neurochem. Res. | pmid:22089933 |
| Leoni V et al. | Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression. | 2013 | Neurobiol. Dis. | pmid:23557875 |
| Teunissen CE et al. | Combination of serum markers related to several mechanisms in Alzheimer's disease. | 2003 | Neurobiol. Aging | pmid:12928047 |
| Koschack J et al. | Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. | 2009 | Neurobiol. Aging | pmid:18061309 |
| Reiss AB et al. | Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease. | 2004 | Neurobiol. Aging | pmid:15212822 |
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| Umetani M et al. | 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. | 2007 | Nat. Med. | pmid:17873880 |
| van de Kraats C et al. | Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis. | 2014 | Mult. Scler. | pmid:23959711 |
| Dujmovic I | Cerebrospinal fluid and blood biomarkers of neuroaxonal damage in multiple sclerosis. | 2011 | Mult Scler Int | pmid:22096642 |
| Hudry E et al. | Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. | 2010 | Mol. Ther. | pmid:19654569 |
| Kölsch H et al. | Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. | 2002 | Mol. Psychiatry | pmid:12232784 |