MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Plaque, Amyloid | D058225 | 19 associated lipids |
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cerebrosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Locatelli S et al. | Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain. | 2002 | Arch. Neurol. | pmid:11843691 |
Vega GL et al. | Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease. | 2003 | Arch. Neurol. | pmid:12707064 |
Papassotiropoulos A et al. | Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. | 2003 | Arch. Neurol. | pmid:12533085 |
Björkhem I and Meaney S | Brain cholesterol: long secret life behind a barrier. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14764421 |
Khenjanta C et al. | Association of CYP39A1, RUNX2 and oxidized alpha-1 antitrypsin expression in relation to cholangiocarcinoma progression. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25556446 |
Burkard I et al. | Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. | 2007 | Atherosclerosis | pmid:17107679 |
Meljon A et al. | Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24491562 |
Famer D et al. | Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17532301 |
Gabbi C et al. | Action mechanisms of Liver X Receptors. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24300092 |
Noguchi N et al. | Diverse functions of 24(S)-hydroxycholesterol in the brain. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24530911 |