Cerebrosterol

Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cerebrosterol?

Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cerebrosterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Nerve Degeneration D009410 53 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Cerebrosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cerebrosterol?

Related references are published most in these journals:

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What functions are associated with Cerebrosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Cerebrosterol?

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What genes are associated with Cerebrosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cerebrosterol?

Mouse Model

Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Cerebrosterol

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Authors Title Published Journal PubMed Link
Karrenbauer VD et al. Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis. 2006 Clin Neurol Neurosurg pmid:16144738
Leoni V et al. Diagnostic use of cerebral and extracerebral oxysterols. 2004 Clin. Chem. Lab. Med. pmid:15061359
Solfrizzi V et al. Circulating biomarkers of cognitive decline and dementia. 2006 Clin. Chim. Acta pmid:16139826
Vega GL et al. The effects of gender and CYP46 and apo E polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients treated with statins. 2004 Curr Alzheimer Res pmid:15975088
Joffre C et al. Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. 2007 Curr. Eye Res. pmid:17453947
Jeitner TM et al. Oxysterol derivatives of cholesterol in neurodegenerative disorders. 2011 Curr. Med. Chem. pmid:21428891
Cook IT et al. 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation. 2009 Drug Metab. Dispos. pmid:19589875
Sodero AO et al. Cholesterol loss during glutamate-mediated excitotoxicity. 2012 EMBO J. pmid:22343944
Thelen KM et al. Effect of pravastatin on plasma sterols and oxysterols in men. 2006 Eur. J. Clin. Pharmacol. pmid:16385401
Kölsch H et al. CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. 2009 Eur. Psychiatry pmid:19286353
Lukiw WJ Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer's disease. 2006 Expert Rev Neurother pmid:16734516
Urano Y et al. Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking. 2013 FASEB J. pmid:23839932
Seet RC et al. Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? 2011 Free Radic. Biol. Med. pmid:21420490
Seet RC et al. Oxidative damage in dengue fever. 2009 Free Radic. Biol. Med. pmid:19427377
Virginio VW et al. Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. 2015 Free Radic. Res. pmid:25465091
Valenza M et al. Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation. 2007 Hum. Mol. Genet. pmid:17613541
Burlot MA et al. Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology. 2015 Hum. Mol. Genet. pmid:26358780
Panzenboeck U et al. Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells. 2006 Int. J. Biochem. Cell Biol. pmid:16530456
Kölsch H et al. Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease. 2006 Int. J. Mol. Med. pmid:16596262
Freemantle E et al. Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. 2013 Int. J. Neuropsychopharmacol. pmid:23369504
Fourgeux C et al. Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration. 2012 Invest. Ophthalmol. Vis. Sci. pmid:22977134
Fourgeux C et al. Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. 2009 Invest. Ophthalmol. Vis. Sci. pmid:19553612
Mast N et al. Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. 2011 Invest. Ophthalmol. Vis. Sci. pmid:20881306
Thelen KM et al. High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. 2006 J Clin Pharmacol pmid:16809807
Papassotiropoulos A et al. A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. 2005 J Clin Psychiatry pmid:16013913
Kölsch H et al. Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. 2001 J Neural Transm pmid:11475014
Sauder S et al. Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients. 2005 J Neural Transm pmid:15666037
Kölsch H et al. Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of Alzheimer's disease. 2006 J Neural Transm pmid:15959845
Kölsch H et al. The role of 24S-hydroxycholesterol in Alzheimer's disease. 2003 J Nutr Health Aging pmid:12679839
Papassotiropoulos A et al. 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. 2002 Jan-Feb J Psychiatr Res pmid:11755458
Sugimoto H et al. Method development for the determination of 24S-hydroxycholesterol in human plasma without derivatization by high-performance liquid chromatography with tandem mass spectrometry in atmospheric pressure chemical ionization mode. 2015 J Sep Sci pmid:26249017
Hughes TM et al. Brain cholesterol metabolism, oxysterols, and dementia. 2013 J. Alzheimers Dis. pmid:23076077
Wang HL et al. Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. 2016 J. Alzheimers Dis. pmid:26836015
Hughes TM et al. Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. 2012 J. Alzheimers Dis. pmid:22377780
Pinçon A et al. Increased susceptibility of dyslipidemic LSR+/- mice to amyloid stress is associated with changes in cortical cholesterol levels. 2015 J. Alzheimers Dis. pmid:25690661
Leoni V et al. Diagnostic power of 24S-hydroxycholesterol in cerebrospinal fluid: candidate marker of brain health. 2013 J. Alzheimers Dis. pmid:23666171
Saint-Pol J et al. Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-β peptide accumulation. 2012 J. Alzheimers Dis. pmid:22433669
Bodin K et al. Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. 2001 J. Biol. Chem. pmid:11514559
Bjorkhem I et al. From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans. 2001 J. Biol. Chem. pmid:11463788
Meir K et al. Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis. 2002 J. Biol. Chem. pmid:12119285
Abildayeva K et al. 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. 2006 J. Biol. Chem. pmid:16524875
Li-Hawkins J et al. Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. 2000 J. Biol. Chem. pmid:10748047
Lehmann JM et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. 1997 J. Biol. Chem. pmid:9013544
Breuer O and Björkhem I Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. 1995 J. Biol. Chem. pmid:7657597
Björkhem I et al. Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro. 1997 J. Biol. Chem. pmid:9374499
Mateos L et al. Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. 2011 J. Biol. Chem. pmid:21628469
Brown J et al. Differential expression of cholesterol hydroxylases in Alzheimer's disease. 2004 J. Biol. Chem. pmid:15148325
Yamanaka K et al. 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. 2011 J. Biol. Chem. pmid:21613228
Björkhem I Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. 2006 J. Intern. Med. pmid:17116000
Hansson M et al. Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. 2007 J. Intern. Med. pmid:17444890