| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
Total
4
Cerebrosterol
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cerebrosterol?
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cerebrosterol
PubChem Associated disorders and diseases
What pathways are associated with Cerebrosterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cerebrosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Cerebrosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Cerebrosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Cerebrosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Cerebrosterol?
Mouse Model
Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Cerebrosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ali Z et al. | On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice. | 2013 | J. Lipid Res. | pmid:23284090 |
| Hughes TM et al. | Brain cholesterol metabolism, oxysterols, and dementia. | 2013 | J. Alzheimers Dis. | pmid:23076077 |
| Leoni V and Caccia C | Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. | 2013 | Biochem. Pharmacol. | pmid:23541982 |
| Freemantle E et al. | Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. | 2013 | Int. J. Neuropsychopharmacol. | pmid:23369504 |
| Fourgeux C et al. | Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22977134 |
| Sodero AO et al. | Cholesterol loss during glutamate-mediated excitotoxicity. | 2012 | EMBO J. | pmid:22343944 |
| Popp J et al. | Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. | 2012 | J. Neurochem. | pmid:22845771 |
| Fourgeux C et al. | Steady-state levels of retinal 24S-hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat. | 2012 | Acta Ophthalmol | pmid:22998629 |
| Mateos L et al. | side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. | 2012 | Neurodegener Dis | pmid:22236548 |
| Krištofiková Z et al. | Interactions of amyloid β peptide 1-40 and cerebrosterol. | 2012 | Neurochem. Res. | pmid:22089933 |
| Hughes TM et al. | Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. | 2012 | J. Alzheimers Dis. | pmid:22377780 |
| Emanuelsson I and Norlin M | Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells. | 2012 | Neurosci. Lett. | pmid:22884615 |
| Saint-Pol J et al. | Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-β peptide accumulation. | 2012 | J. Alzheimers Dis. | pmid:22433669 |
| Gamba P et al. | Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. | 2011 | Aging Cell | pmid:21272192 |
| Zuliani G et al. | Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study. | 2011 | BMC Neurol | pmid:21970714 |
| Jeitner TM et al. | Oxysterol derivatives of cholesterol in neurodegenerative disorders. | 2011 | Curr. Med. Chem. | pmid:21428891 |
| Vanmierlo T et al. | Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. | 2011 | Plant Foods Hum Nutr | pmid:21431910 |
| Mateos L et al. | Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. | 2011 | J. Biol. Chem. | pmid:21628469 |
| Seet RC et al. | Oxidative damage in ischemic stroke revealed using multiple biomarkers. | 2011 | Stroke | pmid:21700941 |
| Fourgeux C et al. | 24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma. | 2011 | Chem. Phys. Lipids | pmid:21531213 |
| Shafaati M et al. | Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. | 2011 | J. Intern. Med. | pmid:21486371 |
| Dujmovic I | Cerebrospinal fluid and blood biomarkers of neuroaxonal damage in multiple sclerosis. | 2011 | Mult Scler Int | pmid:22096642 |
| Yamanaka K et al. | 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. | 2011 | J. Biol. Chem. | pmid:21613228 |
| Seet RC et al. | Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? | 2011 | Free Radic. Biol. Med. | pmid:21420490 |
| Mast N et al. | Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:20881306 |
| Liao WL et al. | Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain. | 2011 | J. Proteome Res. | pmid:21049985 |
| Serrano-Pozo A et al. | Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers. | 2010 Jul-Sep | Alzheimer Dis Assoc Disord | pmid:20473136 |
| Cartagena CM et al. | 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. | 2010 | Brain Res. | pmid:20053345 |
| Ullrich C et al. | Effects of cholesterol and its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices. | 2010 | Pharmacology | pmid:20571288 |
| Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
| Raina A and Kaul D | LXR-α genomics programmes neuronal death observed in Alzheimer's disease. | 2010 | Apoptosis | pmid:20927647 |
| Hudry E et al. | Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. | 2010 | Mol. Ther. | pmid:19654569 |
| Wang Y et al. | A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). | 2010 | Biochim. Biophys. Acta | pmid:20211758 |
| Shafaati M et al. | The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo. | 2010 | J. Lipid Res. | pmid:19474457 |
| Zhao S et al. | Polar metabolite of cholesterol induces rat cognitive dysfunctions. | 2009 | Neuroscience | pmid:19699274 |
| Kölsch H et al. | CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. | 2009 | Eur. Psychiatry | pmid:19286353 |
| Leoni V | Oxysterols as markers of neurological disease--a review. | 2009 | Scand. J. Clin. Lab. Invest. | pmid:19199127 |
| Liao WL et al. | Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry. | 2009 | Biochemistry | pmid:19317426 |
| Prasanthi JR et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. | 2009 | Mol Neurodegener | pmid:19126211 |
| Fourgeux C et al. | Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19553612 |
| Cook IT et al. | 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation. | 2009 | Drug Metab. Dispos. | pmid:19589875 |
| Koschack J et al. | Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. | 2009 | Neurobiol. Aging | pmid:18061309 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Seet RC et al. | Oxidative damage in dengue fever. | 2009 | Free Radic. Biol. Med. | pmid:19427377 |
| Weiner MF et al. | Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. | 2008 | Brain Inj | pmid:18568715 |
| Bang HJ et al. | A comparison of the potential unfavorable effects of oxycholesterol and oxyphytosterol in mice: different effects, on cerebral 24S-hydroxychoelsterol and serum triacylglycerols levels. | 2008 | Biosci. Biotechnol. Biochem. | pmid:19060413 |
| Rantham Prabhakara JP et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. | 2008 | J. Neurochem. | pmid:19014385 |
| Kristofiková Z et al. | Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers. | 2008 | Neurochem. Res. | pmid:17717740 |
| Leoni V et al. | Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease. | 2008 | Brain | pmid:18772220 |