MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Plaque, Amyloid | D058225 | 19 associated lipids |
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cerebrosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Leoni V et al. | Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease. | 2008 | Brain | pmid:18772220 |
Weiner MF et al. | Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. | 2008 | Brain Inj | pmid:18568715 |
Cartagena CM et al. | 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. | 2010 | Brain Res. | pmid:20053345 |
Saint-Pol J et al. | Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. | 2013 | Brain Res. | pmid:23603412 |
Kölsch H et al. | The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. | 1999 | Brain Res. | pmid:9914453 |
Yamanaka K et al. | Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1. | 2014 | Cell Death Dis | pmid:24407243 |
Chen W et al. | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. | 2007 | Cell Metab. | pmid:17189208 |
Fourgeux C et al. | 24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma. | 2011 | Chem. Phys. Lipids | pmid:21531213 |
Gambert S et al. | Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol. | 2017 | Chem. Phys. Lipids | pmid:28576383 |
Bezine M et al. | Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. | 2017 | Chem. Phys. Lipids | pmid:28322741 |