| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
Total
4
Cerebrosterol
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cerebrosterol?
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cerebrosterol
PubChem Associated disorders and diseases
What pathways are associated with Cerebrosterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cerebrosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Cerebrosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Cerebrosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Cerebrosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Cerebrosterol?
Mouse Model
Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Cerebrosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ali Z et al. | On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice. | 2013 | J. Lipid Res. | pmid:23284090 |
| Björkhem I et al. | Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. | 1998 | J. Lipid Res. | pmid:9717719 |
| Karu K et al. | Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. | 2007 | J. Lipid Res. | pmid:17251593 |
| Lütjohann D et al. | Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. | 2000 | J. Lipid Res. | pmid:10681402 |
| Norlin M et al. | On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. | 2003 | J. Lipid Res. | pmid:12777473 |
| Leoni V et al. | Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. | 2003 | J. Lipid Res. | pmid:12562838 |
| Bretillon L et al. | Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. | 2000 | J. Lipid Res. | pmid:10787445 |
| Axelson M et al. | Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. | 1995 | J. Lipid Res. | pmid:7751816 |
| Burkard I et al. | Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. | 2004 | J. Lipid Res. | pmid:14729854 |
| Meaney S et al. | Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. | 2001 | J. Lipid Res. | pmid:11160367 |
| Heverin M et al. | Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. | 2004 | J. Lipid Res. | pmid:14523054 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Björkhem I | Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. | 2006 | J. Intern. Med. | pmid:17116000 |
| Shafaati M et al. | Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. | 2011 | J. Intern. Med. | pmid:21486371 |
| Hansson M et al. | Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. | 2007 | J. Intern. Med. | pmid:17444890 |
| Bodin K et al. | Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. | 2001 | J. Biol. Chem. | pmid:11514559 |
| Bjorkhem I et al. | From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans. | 2001 | J. Biol. Chem. | pmid:11463788 |
| Abildayeva K et al. | 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. | 2006 | J. Biol. Chem. | pmid:16524875 |
| Li-Hawkins J et al. | Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. | 2000 | J. Biol. Chem. | pmid:10748047 |
| Lehmann JM et al. | Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. | 1997 | J. Biol. Chem. | pmid:9013544 |