MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Plaque, Amyloid | D058225 | 19 associated lipids |
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cerebrosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fourgeux C et al. | Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22977134 |
Fourgeux C et al. | Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19553612 |
Mast N et al. | Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:20881306 |
Thelen KM et al. | High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. | 2006 | J Clin Pharmacol | pmid:16809807 |
Papassotiropoulos A et al. | A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. | 2005 | J Clin Psychiatry | pmid:16013913 |
Kölsch H et al. | Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. | 2001 | J Neural Transm | pmid:11475014 |
Sauder S et al. | Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients. | 2005 | J Neural Transm | pmid:15666037 |
Kölsch H et al. | Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of Alzheimer's disease. | 2006 | J Neural Transm | pmid:15959845 |
Kölsch H et al. | The role of 24S-hydroxycholesterol in Alzheimer's disease. | 2003 | J Nutr Health Aging | pmid:12679839 |
Papassotiropoulos A et al. | 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. | 2002 Jan-Feb | J Psychiatr Res | pmid:11755458 |