| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
Total
4
Cerebrosterol
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cerebrosterol?
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cerebrosterol
PubChem Associated disorders and diseases
What pathways are associated with Cerebrosterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cerebrosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Cerebrosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Cerebrosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Cerebrosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Cerebrosterol?
Mouse Model
Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Cerebrosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vogelvang TE et al. | Effect of raloxifene and hormone therapy on serum markers of brain and whole-body cholesterol metabolism in postmenopausal women. | 2005 | Maturitas | pmid:15780532 |
| Prasanthi JR et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. | 2009 | Mol Neurodegener | pmid:19126211 |
| Maarup TJ et al. | Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann-Pick C1. | 2015 Sep-Oct | Mol. Genet. Metab. | pmid:26189084 |
| Kölsch H et al. | Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. | 2002 | Mol. Psychiatry | pmid:12232784 |
| Hudry E et al. | Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. | 2010 | Mol. Ther. | pmid:19654569 |
| Dujmovic I | Cerebrospinal fluid and blood biomarkers of neuroaxonal damage in multiple sclerosis. | 2011 | Mult Scler Int | pmid:22096642 |
| van de Kraats C et al. | Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis. | 2014 | Mult. Scler. | pmid:23959711 |
| Umetani M et al. | 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. | 2007 | Nat. Med. | pmid:17873880 |
| Teunissen CE et al. | Combination of serum markers related to several mechanisms in Alzheimer's disease. | 2003 | Neurobiol. Aging | pmid:12928047 |
| Koschack J et al. | Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. | 2009 | Neurobiol. Aging | pmid:18061309 |
| Reiss AB et al. | Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease. | 2004 | Neurobiol. Aging | pmid:15212822 |
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| Leoni V et al. | Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression. | 2013 | Neurobiol. Dis. | pmid:23557875 |
| Kristofiková Z et al. | Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers. | 2008 | Neurochem. Res. | pmid:17717740 |
| Krištofiková Z et al. | Interactions of amyloid β peptide 1-40 and cerebrosterol. | 2012 | Neurochem. Res. | pmid:22089933 |
| Mateos L et al. | side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. | 2012 | Neurodegener Dis | pmid:22236548 |
| Linsenbardt AJ et al. | Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. | 2014 | Neuropharmacology | pmid:24878244 |
| Kasimov MR et al. | 24S-Hydroxycholesterol enhances synaptic vesicle cycling in the mouse neuromuscular junction: Implication of glutamate NMDA receptors and nitric oxide. | 2017 | Neuropharmacology | pmid:28153530 |
| Alexandrov P et al. | 24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells. | 2005 | Neuroreport | pmid:15931060 |
| Papassotiropoulos A et al. | Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease. | 2000 | Neuroreport | pmid:10884051 |