7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kang KA et al. | Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells. | 2005 | Biol. Pharm. Bull. | pmid:16079477 |
| Kim DH and Frangos JA | Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols. | 2008 | Biophys. J. | pmid:18390616 |
| Tomoyori H et al. | Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036056 |
| Sato H et al. | Oxysterol regulation of estrogen receptor alpha-mediated gene expression in a transcriptional activation assay system using HeLa cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15322366 |
| Maguire L et al. | Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7beta-hydroxycholesterol, in cultured mammalian cells. | 2003 | Br. J. Nutr. | pmid:13129445 |
| Lordan S et al. | Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells. | 2008 | Br. J. Nutr. | pmid:18186953 |
| Ryan L et al. | The role of the mitochondria in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide. | 2005 | Br. J. Nutr. | pmid:16197575 |
| Meynier A et al. | Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters. | 2002 | Br. J. Nutr. | pmid:12010578 |
| Ando M et al. | Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis. | 2002 | Br. J. Nutr. | pmid:12323083 |
| Martin S et al. | Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. | 2003 | Br. J. Pharmacol. | pmid:12871827 |