7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hietter H et al. | Antagonist action of cholesterol towards the toxicity of hydroxysterols on cultured hepatoma cells. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732777 |
| Sudjana-Sugiaman E et al. | Presence of cholesterol 7 alpha-hydroxylase enzyme protein in COS-cells leads to increased HMG CoA reductase activity. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048962 |
| Richert L et al. | Growth-rate-related and hydroxysterol-induced changes in membrane fluidity of cultured hepatoma cells: correlation with 3-hydroxy-3-methyl glutaryl CoA reductase activity. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6538790 |
| Richert L et al. | The importance of serum lipoproteins in the cytolytic action of 7 beta-hydroxycholesterol on cultured hepatoma cells. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6667274 |
| Monier S et al. | Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670484 |
| Li W et al. | Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21621514 |
| Son Y et al. | Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23876312 |
| Carpenter KL et al. | Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. | 1994 | Biochem. J. | pmid:7999000 |
| Javitt NB and Budai K | Cholesterol and bile acid synthesis in Hep G2 cells. Metabolic effects of 26- and 7 alpha-hydroxycholesterol. | 1989 | Biochem. J. | pmid:2556116 |
| Seltman H et al. | Regulation of bile-acid synthesis. Role of sterol carrier protein 2 in the biosynthesis of 7 alpha-hydroxycholesterol. | 1985 | Biochem. J. | pmid:4052036 |