7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Chan WY et al. | Antiproliferative and teratogenic activities of the bishemisuccinates of 7 alpha-hydroxycholesterol and 7 beta-hydroxycholesterol. | 1994 | Gen. Pharmacol. | pmid:7958740 |
| Okamoto S et al. | Serum 7 alpha-hydroxycholesterol reflects hepatic bile acid synthesis in patients with obstructive jaundice after external biliary drainage. | 1994 | Hepatology | pmid:8020910 |
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| Tamasawa N et al. | The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7 alpha-hydroxylase activity in rat. | 1994 | Biochim. Biophys. Acta | pmid:8068724 |
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| Dowling L and Devery R | Use of HPLC for the determination of serum 7 alpha-hydroxycholesterol in cholestyramine-treated rats. | 1995 | Biochem. Soc. Trans. | pmid:7672391 |
| Guyton JR et al. | Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. | 1995 | Atherosclerosis | pmid:8770318 |
| Hahn C et al. | Serum concentration of 7 alpha-hydroxycholesterol as an indicator of bile acid synthesis in humans. | 1995 | J. Lipid Res. | pmid:8558093 |
| Kuroki S et al. | Serum 7 alpha-hydroxycholesterol as a new parameter of liver function in patients with chronic liver diseases. | 1995 | Hepatology | pmid:7557870 |
| Bochelen D et al. | Effect of oxysterol treatment on cholesterol biosynthesis and reactive astrocyte proliferation in injured rat brain cortex. | 1995 | J. Neurochem. | pmid:7595507 |
| Carpenter KL et al. | Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development. | 1995 | Biochim. Biophys. Acta | pmid:7766691 |
| Breuer O and Björkhem I | Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. | 1995 | J. Biol. Chem. | pmid:7657597 |
| Nakano K et al. | Hepatic cholesterol 7 alpha-hydroxylase activity and serum 7 alpha-hydroxy-cholesterol level during liver regeneration after partial hepatectomy in rats. | 1995 | Eur Surg Res | pmid:8542924 |
| Aupeix K et al. | Oyxsterols induce membrane procoagulant activity in monocytic THP-1 cells. | 1996 | Biochem. J. | pmid:8615754 |
| Sauter G et al. | Formation of cholic acid and chenodeoxycholic acid from 7 alpha-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes. | 1996 | Biochim. Biophys. Acta | pmid:8608157 |
| Patel RP et al. | Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. | 1996 | J. Lipid Res. | pmid:8978488 |
| Ito T et al. | Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol. | 1996 | Gastroenterology | pmid:8613070 |
| Krut LH et al. | The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9108794 |
| Lizard G et al. | Induction of apoptosis and of interleukin-1beta secretion by 7beta-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression. | 1997 | FEBS Lett. | pmid:9428650 |
| Maeda Y et al. | Sex difference in serum 7 alpha-hydroxycholesterol levels in the rat reflect hepatic activity of 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase and cholesterol 7 alpha-hydroxylase. | 1997 | J. Gastroenterol. | pmid:9250898 |
| Salonen JT et al. | Lipoprotein oxidation and progression of carotid atherosclerosis. | 1997 | Circulation | pmid:9054740 |
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| Kuroki S et al. | Cholestyramine loading test to assess hepatic reserve for bile acid synthesis in patients with chronic liver diseases. | 1997 | Gastroenterology | pmid:9098013 |
| Tamasawa N et al. | Reduction of oxysterol levels up-regulates HMG-CoA reductase activity in rat liver. | 1997 | Atherosclerosis | pmid:9199277 |
| Vine DF et al. | Dietary oxysterols are incorporated in plasma triglyceride-rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits. | 1998 | J. Lipid Res. | pmid:9788246 |
| Andersson U et al. | Rabbit liver contains one major sterol 12alpha-hydroxylase with broad substrate specificity. | 1998 | Biochim. Biophys. Acta | pmid:9461256 |
| Wakefield AE et al. | The use of lipid-coated microbubbles as a delivery agent of 7beta-hydroxycholesterol in a radiofrequency lesion in the rat brain. | 1998 | Neurosurgery | pmid:9526993 |
| Lemaire S et al. | Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol. | 1998 | FEBS Lett. | pmid:9872417 |
| Stengel D et al. | Inhibition of LPL expression in human monocyte-derived macrophages is dependent on LDL oxidation state: a key role for lysophosphatidylcholine. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9672079 |
| Saisho Y et al. | Determination of 7alpha-hydroxycholesterol in dog plasma by high-performance liquid chromatography with fluorescence detection. | 1998 | Anal. Biochem. | pmid:9882415 |
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| Del Puppo M et al. | Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway. | 1998 | J. Lipid Res. | pmid:9831637 |
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| Kuroki S et al. | Effects of cholestyramine on hepatic cholesterol 7alpha-hydroxylase and serum 7alpha-hydroxycholesterol in the hamster. | 1999 | Lipids | pmid:10529092 |
| Zarev S et al. | Major differences in oxysterol formation in human low density lipoproteins (LDLs) oxidized by *OH/O2*- free radicals or by copper. | 1999 | FEBS Lett. | pmid:10371147 |
| Lizard G et al. | Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10323769 |
| Ziedén B et al. | Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10195924 |
| Furster C | Hepatic and extrahepatic dehydrogenation/isomerization of 5-cholestene-3 beta,7 alpha-diol: localization of 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase in pig tissues and subcellular fractions. | 1999 | Biochim. Biophys. Acta | pmid:9989265 |
| O'Callaghan YC et al. | Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations. | 1999 | Eur J Nutr | pmid:10784381 |
| Ares MP et al. | 7beta-hydroxycholesterol induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. | 2000 | Atherosclerosis | pmid:11058697 |
| Bochelen D et al. | 7beta-hydroxysterol is cytotoxic to neonatal rat astrocytes in primary culture when cAMP levels are increased. | 2000 | J. Neurosci. Res. | pmid:11002292 |
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| Miguet C et al. | Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | 2001 | Cell Death Differ. | pmid:11313706 |
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| Lee T and Chau L | Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11171590 |
| Yasunobu Y et al. | Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols. | 2001 | Atherosclerosis | pmid:11254916 |
| Bansal G et al. | Effect of 7beta-hydroxycholesterol on cellular redox status and heat shock protein 70 expression in macrophages. | 2001 | Cell. Physiol. Biochem. | pmid:11684812 |
| Beaudeux JL et al. | Comparison of the effects of O2*-/HO* free radical- and copper ions-oxidized LDL or lipoprotein(a) on the endothelial cell releases of tissue plasminogen activator and plasminogen activator inhibitor-1. | 2001 | Life Sci. | pmid:11681624 |
| Bertolotti M et al. | Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans. | 2001 | Hepatology | pmid:11481606 |
| Li W et al. | Apoptotic death of inflammatory cells in human atheroma. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11451740 |
| Meaney S et al. | Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. | 2001 | J. Lipid Res. | pmid:11160367 |
| Del Puppo M et al. | Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. | 2001 | J. Lipid Res. | pmid:11254756 |
| O'Callaghan YC et al. | Limitations of the single-cell gel electrophoresis assay to monitor apoptosis in U937 and HepG2 cells exposed to 7beta-hydroxycholesterol. | 2001 | Biochem. Pharmacol. | pmid:11322925 |
| Yang SC and Chen KH | The oxidation of cholesterol in the yolk of selective traditional Chinese egg products. | 2001 | Poult. Sci. | pmid:11261569 |
| Miguet-Alfonsi C et al. | Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. | 2002 | Biochem. Pharmacol. | pmid:12147305 |
| Uemura M et al. | Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation. | 2002 | Eur. J. Pharmacol. | pmid:12450566 |
| Maeda Y et al. | A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken. | 2002 | Steroids | pmid:12117617 |
| Meynier A et al. | Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters. | 2002 | Br. J. Nutr. | pmid:12010578 |
| Ando M et al. | Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis. | 2002 | Br. J. Nutr. | pmid:12323083 |
| Csallany AS et al. | Protection of superoxide-induced cholesterol oxidation by antioxidants in protic conditions. | 2002 | Int J Food Sci Nutr | pmid:12396465 |