7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Yao Y et al. | 7beta-hydroxycholesterol reduces the extent of reactive gliosis caused by iron deposition in the hippocampus but does not attenuate the iron-induced seizures in rats. | 2006 | Neuroscience | pmid:16442740 |
| Boaz M et al. | Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort. | 2005 | Nephron Clin Pract | pmid:15849477 |
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| Wang Y et al. | Isolation and identification of two steroid compounds from Oviductus Ranae. | 2010 | Nat. Prod. Res. | pmid:20835952 |
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| Park SH et al. | Dietary compound α-asarone alleviates ER stress-mediated apoptosis in 7β-hydroxycholesterol-challenged macrophages. | 2016 | Mol Nutr Food Res | pmid:26893256 |
| Adachi J et al. | Skeletal muscle and liver oxysterols during fasting and alcohol exposure. | 2006 | Metab. Clin. Exp. | pmid:16324930 |
| Corradini SG et al. | High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. | 2005 | Liver Transpl. | pmid:16258953 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
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| Sanghvi A et al. | Effect of detergents on in vitro 7 alpha-hydroxycholesterol formation by rat liver microsomes. | 1982 | Lipids | pmid:7144453 |
| Vatassery GT et al. | Analysis of hydroxy and keto cholesterols in oxidized brain synaptosomes. | 1997 | Lipids | pmid:9075199 |
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| Adachi J et al. | 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle. | 2003 | Leg Med (Tokyo) | pmid:12935564 |
| Nakagawa K et al. | Protective effect of daidzein against acute ethanol-induced lipid peroxidation in rat jejunum. | 2006 | Kobe J Med Sci | pmid:17006054 |
| Trevisi L et al. | Antiapoptotic and proliferative effects of low concentrations of 7β-hydroxycholesterol in human endothelial cells via ERK activation. | 2010 | J. Vasc. Res. | pmid:19893321 |
| Kuroki S et al. | Effect of biliary drainage on serum 7 alpha-hydroxycholesterol level in patients with obstructive jaundice. | 1994 | J. Surg. Res. | pmid:8072282 |
| Stellaard F et al. | The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27060336 |
| Son HH et al. | Hair sterol signatures coupled to multivariate data analysis reveal an increased 7β-hydroxycholesterol production in cognitive impairment. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:26385606 |
| Shiotsuki H et al. | Purification and characterization of 7beta-hydroxysteroid dehydrogenase from rabbit liver microsomes. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15276626 |