7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Ziedén B et al. | Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10195924 |
| Lizard G et al. | Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10323769 |
| Zarev S et al. | Major differences in oxysterol formation in human low density lipoproteins (LDLs) oxidized by *OH/O2*- free radicals or by copper. | 1999 | FEBS Lett. | pmid:10371147 |
| Kuroki S et al. | Effects of cholestyramine on hepatic cholesterol 7alpha-hydroxylase and serum 7alpha-hydroxycholesterol in the hamster. | 1999 | Lipids | pmid:10529092 |
| O'Callaghan YC et al. | Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations. | 1999 | Eur J Nutr | pmid:10784381 |
| O'Brien NM et al. | Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals. | 2000 | Biochem. Soc. Trans. | pmid:10816093 |
| Li D and Spencer TA | Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. | 2000 | Steroids | pmid:10978732 |
| Bochelen D et al. | 7beta-hydroxysterol is cytotoxic to neonatal rat astrocytes in primary culture when cAMP levels are increased. | 2000 | J. Neurosci. Res. | pmid:11002292 |
| Ares MP et al. | 7beta-hydroxycholesterol induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. | 2000 | Atherosclerosis | pmid:11058697 |
| Meaney S et al. | Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. | 2001 | J. Lipid Res. | pmid:11160367 |
| Lee T and Chau L | Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11171590 |
| Lee JI et al. | Formation of cholesterol oxides in irradiated raw and cooked chicken meat during storage. | 2001 | Poult. Sci. | pmid:11214329 |
| Del Puppo M et al. | Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. | 2001 | J. Lipid Res. | pmid:11254756 |
| Yasunobu Y et al. | Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols. | 2001 | Atherosclerosis | pmid:11254916 |
| Yang SC and Chen KH | The oxidation of cholesterol in the yolk of selective traditional Chinese egg products. | 2001 | Poult. Sci. | pmid:11261569 |
| Miguet C et al. | Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | 2001 | Cell Death Differ. | pmid:11313706 |
| O'Callaghan YC et al. | Limitations of the single-cell gel electrophoresis assay to monitor apoptosis in U937 and HepG2 cells exposed to 7beta-hydroxycholesterol. | 2001 | Biochem. Pharmacol. | pmid:11322925 |
| Li W et al. | Apoptotic death of inflammatory cells in human atheroma. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11451740 |
| Bertolotti M et al. | Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans. | 2001 | Hepatology | pmid:11481606 |
| O'Callaghan YC et al. | Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. | 2001 | Cell Biol. Toxicol. | pmid:11499696 |
| Iuliano L et al. | Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11597949 |
| Beaudeux JL et al. | Comparison of the effects of O2*-/HO* free radical- and copper ions-oxidized LDL or lipoprotein(a) on the endothelial cell releases of tissue plasminogen activator and plasminogen activator inhibitor-1. | 2001 | Life Sci. | pmid:11681624 |
| Bansal G et al. | Effect of 7beta-hydroxycholesterol on cellular redox status and heat shock protein 70 expression in macrophages. | 2001 | Cell. Physiol. Biochem. | pmid:11684812 |
| Rosenblat M and Aviram M | Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E. | 2002 | Atherosclerosis | pmid:11755924 |
| Hayden JM et al. | Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. | 2002 | J. Lipid Res. | pmid:11792719 |
| Duane WC and Javitt NB | Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis? | 2002 | J. Lab. Clin. Med. | pmid:11919549 |
| Meynier A et al. | Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters. | 2002 | Br. J. Nutr. | pmid:12010578 |
| O'Callaghan YC et al. | Characteristics of 7 beta-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937, and a human hepatoma cell line, HepG2. | 2002 | Toxicol In Vitro | pmid:12020597 |
| Tomoyori H et al. | Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036056 |
| Maeda Y et al. | A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken. | 2002 | Steroids | pmid:12117617 |
| Gregorio-King CC et al. | Effect of oxysterols on hematopoietic progenitor cells. | 2002 | Exp. Hematol. | pmid:12135663 |
| Miguet-Alfonsi C et al. | Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. | 2002 | Biochem. Pharmacol. | pmid:12147305 |
| Ando M et al. | Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis. | 2002 | Br. J. Nutr. | pmid:12323083 |
| Baggio SR et al. | Cholesterol oxides, cholesterol, total lipid, and fatty acid composition in turkey meat. | 2002 | J. Agric. Food Chem. | pmid:12358469 |
| Csallany AS et al. | Protection of superoxide-induced cholesterol oxidation by antioxidants in protic conditions. | 2002 | Int J Food Sci Nutr | pmid:12396465 |
| Uemura M et al. | Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation. | 2002 | Eur. J. Pharmacol. | pmid:12450566 |
| Ringseis R and Eder K | Insufficient dietary vitamin e increases the concentration of 7beta-hydroxycholesterol in tissues of rats fed salmon oil. | 2002 | J. Nutr. | pmid:12468614 |
| Linseisen J et al. | Plasma 7beta-hydroxycholesterol as a possible predictor of lung cancer risk. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12496054 |
| Lim HK et al. | Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line. | 2003 | Life Sci. | pmid:12527036 |
| Iuliano L et al. | Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status. | 2003 | Anal. Biochem. | pmid:12531208 |
| Chang MY et al. | Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12663372 |
| Monier S et al. | Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670484 |
| O'Sullivan AJ et al. | Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: modulatory effects of alpha- and gamma-tocopherol. | 2003 May-Jun | J Appl Toxicol | pmid:12794941 |
| Adachi J et al. | Consecutive administration of paraquat to rats induces enhanced cholesterol peroxidation and lung injury. | 2003 | Arch. Toxicol. | pmid:12799775 |
| Martin S et al. | Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. | 2003 | Br. J. Pharmacol. | pmid:12871827 |
| Adachi J et al. | 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle. | 2003 | Leg Med (Tokyo) | pmid:12935564 |
| Flader D et al. | Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil. | 2003 | Int J Vitam Nutr Res | pmid:12951900 |
| Petrón MJ et al. | Identification and quantification of cholesterol and cholesterol oxidation products in different types of Iberian hams. | 2003 | J. Agric. Food Chem. | pmid:12952434 |
| Meaney S et al. | On the origin of the cholestenoic acids in human circulation. | 2003 | Steroids | pmid:12957664 |