7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Botham KM et al. | Bile acid synthesis in isolated rat liver cells. The effect of 7 alpha-hydroxycholesterol. | 1980 | Eur. J. Biochem. | pmid:7363895 |
| Oftebro H et al. | Cerebrotendinous xanthomatosis: defective liver mitochondrial hydroxylation of chenodeoxycholic acid precursors. | 1981 | J. Lipid Res. | pmid:6792308 |
| Sanghvi A et al. | Measurement of cholesterol 7 alpha-hydroxylase activity with selected ion monitoring. | 1981 | J. Lipid Res. | pmid:7276747 |
| Björkhem I et al. | Assay of intermediates in bile acid biosynthesis using isotope dilution--mass spectrometry: hepatic levels in the normal state and in cerebrotendinous xanthomatosis. | 1981 | J. Lipid Res. | pmid:7017048 |
| Sanghvi A et al. | Effect of detergents on in vitro 7 alpha-hydroxycholesterol formation by rat liver microsomes. | 1982 | Lipids | pmid:7144453 |
| Goldman M et al. | Bile acid metabolism in cirrhosis. VIII. Quantitative evaluation of bile acid synthesis from [7 beta-3H]7 alpha-hydroxycholesterol and [G-3H]26-hydroxycholesterol. | 1982 Jan-Feb | Hepatology | pmid:7054068 |
| Richert L et al. | The importance of serum lipoproteins in the cytolytic action of 7 beta-hydroxycholesterol on cultured hepatoma cells. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6667274 |
| Saito H et al. | The regulating effect of cholesterol derivatives isolated from human sera on lymphocyte response to phytohemagglutinin. | 1983 | Tohoku J. Exp. Med. | pmid:6623455 |
| Hietter H et al. | Antagonist action of cholesterol towards the toxicity of hydroxysterols on cultured hepatoma cells. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732777 |
| Richert L et al. | Growth-rate-related and hydroxysterol-induced changes in membrane fluidity of cultured hepatoma cells: correlation with 3-hydroxy-3-methyl glutaryl CoA reductase activity. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6538790 |
| Seltman H et al. | Regulation of bile-acid synthesis. Role of sterol carrier protein 2 in the biosynthesis of 7 alpha-hydroxycholesterol. | 1985 | Biochem. J. | pmid:4052036 |
| Rooney MW et al. | Oxygenated cholesterols synergistically immobilize acyl chains and enhance protein helical structure in human erythrocyte membranes. | 1985 | Biochim. Biophys. Acta | pmid:4052416 |
| Hemmi H et al. | Inhibition of sterol and DNA syntheses in phytohemagglutinin-stimulated human lymphocytes by 7 alpha-hydroxycholesterol. | 1985 | Tohoku J. Exp. Med. | pmid:3992580 |
| Richert L et al. | Inhibition of IL-2 secretion and IL-2 receptor appearance of activated lymphocytes pretreated with hydroxylated sterols. | 1986 | Immunol. Lett. | pmid:3096880 |
| Skrede S et al. | Demonstration of 26-hydroxylation of C27-steroids in human skin fibroblasts, and a deficiency of this activity in cerebrotendinous xanthomatosis. | 1986 | J. Clin. Invest. | pmid:3745434 |
| Polokoff MA and Everson GT | Hepatocyte-hepatoma cell hybrids. Characterization and demonstration of bile acid synthesis. | 1986 | J. Biol. Chem. | pmid:3949804 |
| Björkhem I et al. | On the possible use of the serum level of 7 alpha-hydroxycholesterol as a marker for increased activity of the cholesterol 7 alpha-hydroxylase in humans. | 1987 | J. Lipid Res. | pmid:3668387 |
| Lelong I et al. | Effect of 7 beta-hydroxycholesterol on growth and membrane composition of Mycoplasma capricolum. | 1988 | FEBS Lett. | pmid:3378626 |
| Kupferberg A et al. | Effect of 7 beta-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines: cytotoxicity and metabolism. | 1989 | Biochim. Biophys. Acta | pmid:2804084 |
| Javitt NB and Budai K | Cholesterol and bile acid synthesis in Hep G2 cells. Metabolic effects of 26- and 7 alpha-hydroxycholesterol. | 1989 | Biochem. J. | pmid:2556116 |
| Kupferberg A et al. | Metabolism of 7 beta-hydroxycholesterol in astrocyte primary cultures and derived spontaneously transformed cell lines: correlation between the esterification on C-3 -OH by naturally occurring fatty acids and cytotoxicity. | 1990 | Biochim. Biophys. Acta | pmid:2397239 |
| Kwekkeboom J et al. | Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7 alpha-hydroxylase activity. | 1990 | Hepatology | pmid:2227820 |
| Carpenter KL et al. | Oxidation of cholesteryl linoleate by human monocyte-macrophages in vitro. | 1990 | Atherosclerosis | pmid:2122906 |
| Bascoul J et al. | Serum level of 7 alpha-hydroxycholesterol in hypercholesterolemic patients treated with cholestyramine. | 1990 | Biochim. Biophys. Acta | pmid:2364100 |
| Axelson M et al. | Ethanol has an acute effect on bile acid biosynthesis in man. | 1991 | FEBS Lett. | pmid:2015886 |
| Behr P et al. | Effect of 7 beta-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines. Cytotoxicity and cholesterogenesis. | 1991 | FEBS Lett. | pmid:2013313 |
| Pettersen KS et al. | Toxicity of oxygenated cholesterol derivatives toward cultured human umbilical vein endothelial cells. | 1991 Mar-Apr | Arterioscler. Thromb. | pmid:1900193 |
| Behr P et al. | Effect of dibutyryl cyclic AMP and isoproterenol on 7 beta-hydroxycholesterol cytotoxicity and esterification in spontaneous transformed cell lines derived from astrocyte primary cultures. | 1992 | FEBS Lett. | pmid:1330703 |
| Bochelen D et al. | 7 beta-hydroxycholesterol and 7 beta-hydroxycholesteryl-3-esters reduce the extent of reactive gliosis caused by an electrolytic lesion in rat brain. | 1992 | Neuroscience | pmid:1488125 |
| Kishinaka M et al. | Metabolism of intravenously administered 7 alpha-hydroxycholesterol-3 beta-stearate in the hamster. | 1992 | Biochim. Biophys. Acta | pmid:1450217 |
| Kupferberg A et al. | Separation and purification of dolichol and dolichyl phosphate by anion-exchange paper chromatography: application to cultured cells. | 1992 | Anal. Biochem. | pmid:1443591 |
| Hoang VQ et al. | The regulation of bile acid synthesis in cultured hamster hepatocytes. | 1993 | Biochem. Soc. Trans. | pmid:8224434 |
| Chan WY et al. | Antiproliferative and teratogenic activities of the bishemisuccinates of 7 alpha-hydroxycholesterol and 7 beta-hydroxycholesterol. | 1994 | Gen. Pharmacol. | pmid:7958740 |
| Okamoto S et al. | Serum 7 alpha-hydroxycholesterol reflects hepatic bile acid synthesis in patients with obstructive jaundice after external biliary drainage. | 1994 | Hepatology | pmid:8020910 |
| Kuroki S et al. | Effect of biliary drainage on serum 7 alpha-hydroxycholesterol level in patients with obstructive jaundice. | 1994 | J. Surg. Res. | pmid:8072282 |
| Carpenter KL et al. | Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. | 1994 | Biochem. J. | pmid:7999000 |
| Sudjana-Sugiaman E et al. | Presence of cholesterol 7 alpha-hydroxylase enzyme protein in COS-cells leads to increased HMG CoA reductase activity. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048962 |
| Tamasawa N et al. | The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7 alpha-hydroxylase activity in rat. | 1994 | Biochim. Biophys. Acta | pmid:8068724 |
| Alexander DL and Fisher JF | A convenient synthesis of 7 alpha-hydroxycholest-4-en-3-one by the hydroxypropyl-beta-cyclodextrin-facilitated cholesterol oxidase oxidation of 3 beta,7 alpha-cholest-5-ene-3,7-diol. | 1995 | Steroids | pmid:7792834 |
| Dowling L and Devery R | Use of HPLC for the determination of serum 7 alpha-hydroxycholesterol in cholestyramine-treated rats. | 1995 | Biochem. Soc. Trans. | pmid:7672391 |
| Guyton JR et al. | Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. | 1995 | Atherosclerosis | pmid:8770318 |
| Hahn C et al. | Serum concentration of 7 alpha-hydroxycholesterol as an indicator of bile acid synthesis in humans. | 1995 | J. Lipid Res. | pmid:8558093 |
| Kuroki S et al. | Serum 7 alpha-hydroxycholesterol as a new parameter of liver function in patients with chronic liver diseases. | 1995 | Hepatology | pmid:7557870 |
| Bochelen D et al. | Effect of oxysterol treatment on cholesterol biosynthesis and reactive astrocyte proliferation in injured rat brain cortex. | 1995 | J. Neurochem. | pmid:7595507 |
| Carpenter KL et al. | Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development. | 1995 | Biochim. Biophys. Acta | pmid:7766691 |
| Breuer O and Björkhem I | Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. | 1995 | J. Biol. Chem. | pmid:7657597 |
| Nakano K et al. | Hepatic cholesterol 7 alpha-hydroxylase activity and serum 7 alpha-hydroxy-cholesterol level during liver regeneration after partial hepatectomy in rats. | 1995 | Eur Surg Res | pmid:8542924 |
| Aupeix K et al. | Oyxsterols induce membrane procoagulant activity in monocytic THP-1 cells. | 1996 | Biochem. J. | pmid:8615754 |
| Patel RP et al. | Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. | 1996 | J. Lipid Res. | pmid:8978488 |