7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ruiz E et al. | Human vascular smooth muscle cells from diabetic patients are resistant to induced apoptosis due to high Bcl-2 expression. | 2006 | Diabetes | pmid:16644678 |
| Malvitte L et al. | Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol. | 2008 | Curr. Eye Res. | pmid:18798080 |
| Adachi J et al. | Enhanced lipid peroxidation in tourniquet-release mice. | 2006 | Clin. Chim. Acta | pmid:16624265 |
| Crosignani A et al. | Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis. | 2008 | Clin. Chim. Acta | pmid:18538136 |
| Del Puppo M et al. | A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis. | 2005 | Clin. Chim. Acta | pmid:15820474 |
| Crosignani A et al. | Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease. | 2007 | Clin. Chim. Acta | pmid:17482152 |
| Helmschrodt C et al. | Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque. | 2013 | Clin. Chim. Acta | pmid:23827692 |
| Salonen JT et al. | Lipoprotein oxidation and progression of carotid atherosclerosis. | 1997 | Circulation | pmid:9054740 |
| Rosa A et al. | Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation. | 2008 | Chem. Phys. Lipids | pmid:18498764 |
| Bansal G et al. | Effect of 7beta-hydroxycholesterol on cellular redox status and heat shock protein 70 expression in macrophages. | 2001 | Cell. Physiol. Biochem. | pmid:11684812 |