7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Guéguen Y et al. | Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. | 2006 | Arch. Toxicol. | pmid:16231126 |
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| Nakagawa K et al. | Protective effect of daidzein against acute ethanol-induced lipid peroxidation in rat jejunum. | 2006 | Kobe J Med Sci | pmid:17006054 |
| Yao Y et al. | 7beta-hydroxycholesterol reduces the extent of reactive gliosis caused by iron deposition in the hippocampus but does not attenuate the iron-induced seizures in rats. | 2006 | Neuroscience | pmid:16442740 |
| Maeda Y et al. | Species differences among various rodents in the conversion of 7alpha-hydroxycholesterol in liver microsomes. | 2006 | Steroids | pmid:16455124 |
| Roussi S et al. | Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7beta-hydroxycholesterol and 7beta-hydroxysitosterol. | 2006 | Int. J. Oncol. | pmid:17088995 |
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| Roussi S et al. | Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells. | 2005 | Cell Death Differ. | pmid:15550935 |
| Prunet C et al. | Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7beta-hydroxycholesterol-induced cell death: a morphological and biochemical study. | 2005 | J. Biochem. Mol. Toxicol. | pmid:16292754 |
| Corradini SG et al. | High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. | 2005 | Liver Transpl. | pmid:16258953 |
| Kang KA et al. | Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells. | 2005 | Biol. Pharm. Bull. | pmid:16079477 |
| Boaz M et al. | Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort. | 2005 | Nephron Clin Pract | pmid:15849477 |
| Bai B et al. | Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line (Caco-2). | 2005 | Inflammation | pmid:17086498 |
| Li W et al. | Foam cell death induced by 7beta-hydroxycholesterol is mediated by labile iron-driven oxidative injury: mechanisms underlying induction of ferritin in human atheroma. | 2005 | Free Radic. Biol. Med. | pmid:16140207 |
| Napolitano M and Bravo E | Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages. | 2005 | Eur. J. Clin. Invest. | pmid:16101668 |
| Micheletta F et al. | Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14592846 |
| Ryan L et al. | Comparison of the apoptotic processes induced by the oxysterols 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide. | 2004 | Cell Biol. Toxicol. | pmid:15685934 |
| Sato H et al. | Oxysterol regulation of estrogen receptor alpha-mediated gene expression in a transcriptional activation assay system using HeLa cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15322366 |
| Rodriguez IR et al. | Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol. | 2004 | Invest. Ophthalmol. Vis. Sci. | pmid:15277510 |
| Biasi F et al. | Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation. | 2004 | FASEB J. | pmid:14977888 |
| Ryan L et al. | Generation of an oxidative stress precedes caspase activation during 7beta-hydroxycholesterol-induced apoptosis in U937 cells. | 2004 | J. Biochem. Mol. Toxicol. | pmid:14994280 |
| Schweizer RA et al. | Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. | 2004 | J. Biol. Chem. | pmid:14973125 |
| Li W et al. | Enhanced expression of natural resistance-associated macrophage protein 1 in atherosclerotic lesions may be associated with oxidized lipid-induced apoptosis. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15659799 |
| Li W and Yuan XM | Increased expression and translocation of lysosomal cathepsins contribute to macrophage apoptosis in atherogenesis. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15659826 |
| Shiotsuki H et al. | Purification and characterization of 7beta-hydroxysteroid dehydrogenase from rabbit liver microsomes. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15276626 |
| Hult M et al. | Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism. | 2004 | Cell. Mol. Life Sci. | pmid:15095019 |
| Kontush A et al. | Vitamin E is not deficient in human atherosclerotic plaques. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15237091 |
| O'Sullivan AJ et al. | Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: modulatory effects of alpha- and gamma-tocopherol. | 2003 May-Jun | J Appl Toxicol | pmid:12794941 |
| Maguire L et al. | Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7beta-hydroxycholesterol, in cultured mammalian cells. | 2003 | Br. J. Nutr. | pmid:13129445 |
| Meaney S et al. | On the origin of the cholestenoic acids in human circulation. | 2003 | Steroids | pmid:12957664 |
| Iuliano L et al. | Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status. | 2003 | Anal. Biochem. | pmid:12531208 |
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Flader D et al. | Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil. | 2003 | Int J Vitam Nutr Res | pmid:12951900 |
| Chang MY et al. | Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12663372 |
| Monier S et al. | Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670484 |
| Lim HK et al. | Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line. | 2003 | Life Sci. | pmid:12527036 |
| Martin S et al. | Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. | 2003 | Br. J. Pharmacol. | pmid:12871827 |
| Adachi J et al. | 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle. | 2003 | Leg Med (Tokyo) | pmid:12935564 |
| Ciuffreda P et al. | Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids. | 2003 | Steroids | pmid:14625005 |
| Adachi J et al. | Consecutive administration of paraquat to rats induces enhanced cholesterol peroxidation and lung injury. | 2003 | Arch. Toxicol. | pmid:12799775 |
| Petrón MJ et al. | Identification and quantification of cholesterol and cholesterol oxidation products in different types of Iberian hams. | 2003 | J. Agric. Food Chem. | pmid:12952434 |
| Rosenblat M and Aviram M | Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E. | 2002 | Atherosclerosis | pmid:11755924 |
| Hayden JM et al. | Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. | 2002 | J. Lipid Res. | pmid:11792719 |
| Baggio SR et al. | Cholesterol oxides, cholesterol, total lipid, and fatty acid composition in turkey meat. | 2002 | J. Agric. Food Chem. | pmid:12358469 |
| Tomoyori H et al. | Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036056 |
| Duane WC and Javitt NB | Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis? | 2002 | J. Lab. Clin. Med. | pmid:11919549 |
| Miguet-Alfonsi C et al. | Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. | 2002 | Biochem. Pharmacol. | pmid:12147305 |
| Gregorio-King CC et al. | Effect of oxysterols on hematopoietic progenitor cells. | 2002 | Exp. Hematol. | pmid:12135663 |
| O'Callaghan YC et al. | Characteristics of 7 beta-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937, and a human hepatoma cell line, HepG2. | 2002 | Toxicol In Vitro | pmid:12020597 |
| Ringseis R and Eder K | Insufficient dietary vitamin e increases the concentration of 7beta-hydroxycholesterol in tissues of rats fed salmon oil. | 2002 | J. Nutr. | pmid:12468614 |
| Uemura M et al. | Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation. | 2002 | Eur. J. Pharmacol. | pmid:12450566 |
| Maeda Y et al. | A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken. | 2002 | Steroids | pmid:12117617 |
| Meynier A et al. | Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters. | 2002 | Br. J. Nutr. | pmid:12010578 |
| Linseisen J et al. | Plasma 7beta-hydroxycholesterol as a possible predictor of lung cancer risk. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12496054 |
| Ando M et al. | Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis. | 2002 | Br. J. Nutr. | pmid:12323083 |
| Csallany AS et al. | Protection of superoxide-induced cholesterol oxidation by antioxidants in protic conditions. | 2002 | Int J Food Sci Nutr | pmid:12396465 |
| Miguet C et al. | Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | 2001 | Cell Death Differ. | pmid:11313706 |
| Iuliano L et al. | Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11597949 |
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| Lee JI et al. | Formation of cholesterol oxides in irradiated raw and cooked chicken meat during storage. | 2001 | Poult. Sci. | pmid:11214329 |
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| Yasunobu Y et al. | Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols. | 2001 | Atherosclerosis | pmid:11254916 |
| Bansal G et al. | Effect of 7beta-hydroxycholesterol on cellular redox status and heat shock protein 70 expression in macrophages. | 2001 | Cell. Physiol. Biochem. | pmid:11684812 |
| Beaudeux JL et al. | Comparison of the effects of O2*-/HO* free radical- and copper ions-oxidized LDL or lipoprotein(a) on the endothelial cell releases of tissue plasminogen activator and plasminogen activator inhibitor-1. | 2001 | Life Sci. | pmid:11681624 |
| Bertolotti M et al. | Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans. | 2001 | Hepatology | pmid:11481606 |
| Li W et al. | Apoptotic death of inflammatory cells in human atheroma. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11451740 |
| Meaney S et al. | Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. | 2001 | J. Lipid Res. | pmid:11160367 |
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| O'Callaghan YC et al. | Limitations of the single-cell gel electrophoresis assay to monitor apoptosis in U937 and HepG2 cells exposed to 7beta-hydroxycholesterol. | 2001 | Biochem. Pharmacol. | pmid:11322925 |
| Yang SC and Chen KH | The oxidation of cholesterol in the yolk of selective traditional Chinese egg products. | 2001 | Poult. Sci. | pmid:11261569 |
| Ares MP et al. | 7beta-hydroxycholesterol induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. | 2000 | Atherosclerosis | pmid:11058697 |
| Bochelen D et al. | 7beta-hydroxysterol is cytotoxic to neonatal rat astrocytes in primary culture when cAMP levels are increased. | 2000 | J. Neurosci. Res. | pmid:11002292 |
| O'Brien NM et al. | Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals. | 2000 | Biochem. Soc. Trans. | pmid:10816093 |
| Li D and Spencer TA | Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. | 2000 | Steroids | pmid:10978732 |
| Kuroki S et al. | Effects of cholestyramine on hepatic cholesterol 7alpha-hydroxylase and serum 7alpha-hydroxycholesterol in the hamster. | 1999 | Lipids | pmid:10529092 |
| Zarev S et al. | Major differences in oxysterol formation in human low density lipoproteins (LDLs) oxidized by *OH/O2*- free radicals or by copper. | 1999 | FEBS Lett. | pmid:10371147 |
| Lizard G et al. | Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10323769 |
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| O'Callaghan YC et al. | Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations. | 1999 | Eur J Nutr | pmid:10784381 |
| Lemaire S et al. | Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol. | 1998 | FEBS Lett. | pmid:9872417 |