7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guéguen Y et al. | Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. | 2006 | Arch. Toxicol. | pmid:16231126 |
| Pettersen KS et al. | Toxicity of oxygenated cholesterol derivatives toward cultured human umbilical vein endothelial cells. | 1991 Mar-Apr | Arterioscler. Thromb. | pmid:1900193 |
| Krut LH et al. | The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9108794 |
| Iuliano L et al. | Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11597949 |
| Stengel D et al. | Inhibition of LPL expression in human monocyte-derived macrophages is dependent on LDL oxidation state: a key role for lysophosphatidylcholine. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9672079 |
| Ziedén B et al. | Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10195924 |
| Li W et al. | Apoptotic death of inflammatory cells in human atheroma. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11451740 |
| Nilsson J et al. | Lipoprotein-like phospholipid particles inhibit the smooth muscle cell cytotoxicity of lysophosphatidylcholine and platelet-activating factor. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9445250 |
| Deckert V et al. | Inhibition by cholesterol oxides of NO release from human vascular endothelial cells. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9672065 |
| Kontush A et al. | Vitamin E is not deficient in human atherosclerotic plaques. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15237091 |