7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| O'Callaghan YC et al. | Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. | 2001 | Cell Biol. Toxicol. | pmid:11499696 |
| Iuliano L et al. | Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11597949 |
| Beaudeux JL et al. | Comparison of the effects of O2*-/HO* free radical- and copper ions-oxidized LDL or lipoprotein(a) on the endothelial cell releases of tissue plasminogen activator and plasminogen activator inhibitor-1. | 2001 | Life Sci. | pmid:11681624 |
| Bansal G et al. | Effect of 7beta-hydroxycholesterol on cellular redox status and heat shock protein 70 expression in macrophages. | 2001 | Cell. Physiol. Biochem. | pmid:11684812 |
| Rosenblat M and Aviram M | Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E. | 2002 | Atherosclerosis | pmid:11755924 |
| Hayden JM et al. | Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. | 2002 | J. Lipid Res. | pmid:11792719 |
| Duane WC and Javitt NB | Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis? | 2002 | J. Lab. Clin. Med. | pmid:11919549 |
| Meynier A et al. | Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters. | 2002 | Br. J. Nutr. | pmid:12010578 |
| O'Callaghan YC et al. | Characteristics of 7 beta-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937, and a human hepatoma cell line, HepG2. | 2002 | Toxicol In Vitro | pmid:12020597 |
| Tomoyori H et al. | Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036056 |