7beta-Hydroxycholesterol

7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.

Cross Reference

Introduction

To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 7beta-Hydroxycholesterol?

7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Carotid Stenosis D016893 15 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Total 5

PubChem Associated disorders and diseases

What pathways are associated with 7beta-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 7beta-Hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 7beta-Hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 7beta-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 7beta-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 7beta-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 7beta-Hydroxycholesterol

Download all related citations
Per page 10 20 50 100 | Total 269
Authors Title Published Journal PubMed Link
Maeda Y et al. Sex difference in serum 7 alpha-hydroxycholesterol levels in the rat reflect hepatic activity of 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase and cholesterol 7 alpha-hydroxylase. 1997 J. Gastroenterol. pmid:9250898
Hansson M et al. Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. 2007 J. Intern. Med. pmid:17444890
Duane WC and Javitt NB Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis? 2002 J. Lab. Clin. Med. pmid:11919549
Björkhem I et al. On the possible use of the serum level of 7 alpha-hydroxycholesterol as a marker for increased activity of the cholesterol 7 alpha-hydroxylase in humans. 1987 J. Lipid Res. pmid:3668387
Vine DF et al. Dietary oxysterols are incorporated in plasma triglyceride-rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits. 1998 J. Lipid Res. pmid:9788246
Hahn C et al. Serum concentration of 7 alpha-hydroxycholesterol as an indicator of bile acid synthesis in humans. 1995 J. Lipid Res. pmid:8558093
Oftebro H et al. Cerebrotendinous xanthomatosis: defective liver mitochondrial hydroxylation of chenodeoxycholic acid precursors. 1981 J. Lipid Res. pmid:6792308
Sanghvi A et al. Measurement of cholesterol 7 alpha-hydroxylase activity with selected ion monitoring. 1981 J. Lipid Res. pmid:7276747
Björkhem I et al. Assay of intermediates in bile acid biosynthesis using isotope dilution--mass spectrometry: hepatic levels in the normal state and in cerebrotendinous xanthomatosis. 1981 J. Lipid Res. pmid:7017048
Hayden JM et al. Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. 2002 J. Lipid Res. pmid:11792719
Patel RP et al. Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. 1996 J. Lipid Res. pmid:8978488
Meaney S et al. Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. 2001 J. Lipid Res. pmid:11160367
Del Puppo M et al. Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. 2001 J. Lipid Res. pmid:11254756
Honda A et al. Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. 2009 J. Lipid Res. pmid:18815436
Del Puppo M et al. Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway. 1998 J. Lipid Res. pmid:9831637
Bochelen D et al. Effect of oxysterol treatment on cholesterol biosynthesis and reactive astrocyte proliferation in injured rat brain cortex. 1995 J. Neurochem. pmid:7595507
Loke SY et al. Comprehensive gene expression analyses of the rat prefrontal cortex after oxysterol treatment. 2013 J. Neurochem. pmid:23294445
Bochelen D et al. 7beta-hydroxysterol is cytotoxic to neonatal rat astrocytes in primary culture when cAMP levels are increased. 2000 J. Neurosci. Res. pmid:11002292
Ringseis R and Eder K Insufficient dietary vitamin e increases the concentration of 7beta-hydroxycholesterol in tissues of rats fed salmon oil. 2002 J. Nutr. pmid:12468614
Stellaard F et al. The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. 2017 J. Steroid Biochem. Mol. Biol. pmid:27060336
Son HH et al. Hair sterol signatures coupled to multivariate data analysis reveal an increased 7β-hydroxycholesterol production in cognitive impairment. 2016 J. Steroid Biochem. Mol. Biol. pmid:26385606
Shiotsuki H et al. Purification and characterization of 7beta-hydroxysteroid dehydrogenase from rabbit liver microsomes. 2004 J. Steroid Biochem. Mol. Biol. pmid:15276626
Kuroki S et al. Effect of biliary drainage on serum 7 alpha-hydroxycholesterol level in patients with obstructive jaundice. 1994 J. Surg. Res. pmid:8072282
Trevisi L et al. Antiapoptotic and proliferative effects of low concentrations of 7β-hydroxycholesterol in human endothelial cells via ERK activation. 2010 J. Vasc. Res. pmid:19893321
Nakagawa K et al. Protective effect of daidzein against acute ethanol-induced lipid peroxidation in rat jejunum. 2006 Kobe J Med Sci pmid:17006054
Adachi J et al. 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle. 2003 Leg Med (Tokyo) pmid:12935564
Beaudeux JL et al. Comparison of the effects of O2*-/HO* free radical- and copper ions-oxidized LDL or lipoprotein(a) on the endothelial cell releases of tissue plasminogen activator and plasminogen activator inhibitor-1. 2001 Life Sci. pmid:11681624
Lim HK et al. Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line. 2003 Life Sci. pmid:12527036
Kuroki S et al. Effects of cholestyramine on hepatic cholesterol 7alpha-hydroxylase and serum 7alpha-hydroxycholesterol in the hamster. 1999 Lipids pmid:10529092
Sanghvi A et al. Effect of detergents on in vitro 7 alpha-hydroxycholesterol formation by rat liver microsomes. 1982 Lipids pmid:7144453
Vatassery GT et al. Analysis of hydroxy and keto cholesterols in oxidized brain synaptosomes. 1997 Lipids pmid:9075199
Yoshida Y et al. Levels of lipid peroxidation in human plasma and erythrocytes: comparison between fatty acids and cholesterol. 2007 Lipids pmid:17476548
Menéndez-Carreño M et al. Inhibition of serum cholesterol oxidation by dietary vitamin C and selenium intake in high fat fed rats. 2008 Lipids pmid:18335267
Iborra RT et al. Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. 2011 Lipids Health Dis pmid:21957962
Jusakul A et al. Mechanisms of oxysterol-induced carcinogenesis. 2011 Lipids Health Dis pmid:21388551
Corradini SG et al. High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. 2005 Liver Transpl. pmid:16258953
Adachi J et al. Skeletal muscle and liver oxysterols during fasting and alcohol exposure. 2006 Metab. Clin. Exp. pmid:16324930
Park SH et al. Dietary compound α-asarone alleviates ER stress-mediated apoptosis in 7β-hydroxycholesterol-challenged macrophages. 2016 Mol Nutr Food Res pmid:26893256
Hall MC The effect of oxysterols, individually and as a representative mixture from food, on in vitro cultured bovine ovarian granulosa cells. 2006 Mol. Cell. Biochem. pmid:16983501
Keune WJ et al. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. 2016 Nat Commun pmid:27075612
Wang Y et al. Isolation and identification of two steroid compounds from Oviductus Ranae. 2010 Nat. Prod. Res. pmid:20835952
Liu C et al. Oxysterols direct B-cell migration through EBI2. 2011 Nature pmid:21796211
Boaz M et al. Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort. 2005 Nephron Clin Pract pmid:15849477
Bochelen D et al. 7 beta-hydroxycholesterol and 7 beta-hydroxycholesteryl-3-esters reduce the extent of reactive gliosis caused by an electrolytic lesion in rat brain. 1992 Neuroscience pmid:1488125
Jenner AM et al. The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. 2010 Neuroscience pmid:20416362
Yao Y et al. 7beta-hydroxycholesterol reduces the extent of reactive gliosis caused by iron deposition in the hippocampus but does not attenuate the iron-induced seizures in rats. 2006 Neuroscience pmid:16442740
Wakefield AE et al. The use of lipid-coated microbubbles as a delivery agent of 7beta-hydroxycholesterol in a radiofrequency lesion in the rat brain. 1998 Neurosurgery pmid:9526993
Wong WT et al. Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. 2011 Nutr Metab Cardiovasc Dis pmid:20005687
Park SH et al. α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy. 2017 Oncotarget pmid:28088783
Prunet C et al. High circulating levels of 7beta- and 7alpha-hydroxycholesterol and presence of apoptotic and oxidative markers in arterial lesions of normocholesterolemic atherosclerotic patients undergoing endarterectomy. 2006 Pathol. Biol. pmid:16376175
Laskar A et al. Fodipir and its dephosphorylated derivative dipyridoxyl ethyldiamine are involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death. 2013 Pharmacology pmid:24080534
Cho HR et al. 7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor. 2017 PLoS ONE pmid:28323848
Testa G et al. Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. 2014 PLoS ONE pmid:24802026
Goldman A et al. The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells. 2011 PLoS ONE pmid:21887327
Nashev LG et al. Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. 2007 PLoS ONE pmid:17593962
Lee JI et al. Formation of cholesterol oxides in irradiated raw and cooked chicken meat during storage. 2001 Poult. Sci. pmid:11214329
Yang SC and Chen KH The oxidation of cholesterol in the yolk of selective traditional Chinese egg products. 2001 Poult. Sci. pmid:11261569
Meaney S et al. On the origin of the cholestenoic acids in human circulation. 2003 Steroids pmid:12957664
Alexander DL and Fisher JF A convenient synthesis of 7 alpha-hydroxycholest-4-en-3-one by the hydroxypropyl-beta-cyclodextrin-facilitated cholesterol oxidase oxidation of 3 beta,7 alpha-cholest-5-ene-3,7-diol. 1995 Steroids pmid:7792834
Nury T et al. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). 2015 Steroids pmid:25683890
Maeda Y et al. A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken. 2002 Steroids pmid:12117617
Brunel JM et al. Synthesis and antifungal activity of oxygenated cholesterol derivatives. 2005 Steroids pmid:16139854
Ciuffreda P et al. Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids. 2003 Steroids pmid:14625005
Maeda Y et al. Species differences among various rodents in the conversion of 7alpha-hydroxycholesterol in liver microsomes. 2006 Steroids pmid:16455124
Li D and Spencer TA Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. 2000 Steroids pmid:10978732
Saito H et al. The regulating effect of cholesterol derivatives isolated from human sera on lymphocyte response to phytohemagglutinin. 1983 Tohoku J. Exp. Med. pmid:6623455
Hemmi H et al. Inhibition of sterol and DNA syntheses in phytohemagglutinin-stimulated human lymphocytes by 7 alpha-hydroxycholesterol. 1985 Tohoku J. Exp. Med. pmid:3992580
O'Callaghan YC et al. Characteristics of 7 beta-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937, and a human hepatoma cell line, HepG2. 2002 Toxicol In Vitro pmid:12020597
Kim SM et al. 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes. 2014 Toxicol. Appl. Pharmacol. pmid:24370436