7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Carpenter KL et al. | Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development. | 1995 | Biochim. Biophys. Acta | pmid:7766691 |
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| Nakano K et al. | Hepatic cholesterol 7 alpha-hydroxylase activity and serum 7 alpha-hydroxy-cholesterol level during liver regeneration after partial hepatectomy in rats. | 1995 | Eur Surg Res | pmid:8542924 |
| Chan WY et al. | Antiproliferative and teratogenic activities of the bishemisuccinates of 7 alpha-hydroxycholesterol and 7 beta-hydroxycholesterol. | 1994 | Gen. Pharmacol. | pmid:7958740 |
| Okamoto S et al. | Serum 7 alpha-hydroxycholesterol reflects hepatic bile acid synthesis in patients with obstructive jaundice after external biliary drainage. | 1994 | Hepatology | pmid:8020910 |
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| Carpenter KL et al. | Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. | 1994 | Biochem. J. | pmid:7999000 |
| Sudjana-Sugiaman E et al. | Presence of cholesterol 7 alpha-hydroxylase enzyme protein in COS-cells leads to increased HMG CoA reductase activity. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048962 |
| Tamasawa N et al. | The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7 alpha-hydroxylase activity in rat. | 1994 | Biochim. Biophys. Acta | pmid:8068724 |
| Hoang VQ et al. | The regulation of bile acid synthesis in cultured hamster hepatocytes. | 1993 | Biochem. Soc. Trans. | pmid:8224434 |
| Behr P et al. | Effect of dibutyryl cyclic AMP and isoproterenol on 7 beta-hydroxycholesterol cytotoxicity and esterification in spontaneous transformed cell lines derived from astrocyte primary cultures. | 1992 | FEBS Lett. | pmid:1330703 |
| Bochelen D et al. | 7 beta-hydroxycholesterol and 7 beta-hydroxycholesteryl-3-esters reduce the extent of reactive gliosis caused by an electrolytic lesion in rat brain. | 1992 | Neuroscience | pmid:1488125 |
| Kishinaka M et al. | Metabolism of intravenously administered 7 alpha-hydroxycholesterol-3 beta-stearate in the hamster. | 1992 | Biochim. Biophys. Acta | pmid:1450217 |
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| Behr P et al. | Effect of 7 beta-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines. Cytotoxicity and cholesterogenesis. | 1991 | FEBS Lett. | pmid:2013313 |
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| Kwekkeboom J et al. | Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7 alpha-hydroxylase activity. | 1990 | Hepatology | pmid:2227820 |
| Carpenter KL et al. | Oxidation of cholesteryl linoleate by human monocyte-macrophages in vitro. | 1990 | Atherosclerosis | pmid:2122906 |
| Bascoul J et al. | Serum level of 7 alpha-hydroxycholesterol in hypercholesterolemic patients treated with cholestyramine. | 1990 | Biochim. Biophys. Acta | pmid:2364100 |
| Kupferberg A et al. | Effect of 7 beta-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines: cytotoxicity and metabolism. | 1989 | Biochim. Biophys. Acta | pmid:2804084 |
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| Björkhem I et al. | On the possible use of the serum level of 7 alpha-hydroxycholesterol as a marker for increased activity of the cholesterol 7 alpha-hydroxylase in humans. | 1987 | J. Lipid Res. | pmid:3668387 |
| Richert L et al. | Inhibition of IL-2 secretion and IL-2 receptor appearance of activated lymphocytes pretreated with hydroxylated sterols. | 1986 | Immunol. Lett. | pmid:3096880 |
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| Seltman H et al. | Regulation of bile-acid synthesis. Role of sterol carrier protein 2 in the biosynthesis of 7 alpha-hydroxycholesterol. | 1985 | Biochem. J. | pmid:4052036 |
| Rooney MW et al. | Oxygenated cholesterols synergistically immobilize acyl chains and enhance protein helical structure in human erythrocyte membranes. | 1985 | Biochim. Biophys. Acta | pmid:4052416 |
| Hemmi H et al. | Inhibition of sterol and DNA syntheses in phytohemagglutinin-stimulated human lymphocytes by 7 alpha-hydroxycholesterol. | 1985 | Tohoku J. Exp. Med. | pmid:3992580 |
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