7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Iuliano L et al. | Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status. | 2003 | Anal. Biochem. | pmid:12531208 |
| Chang MY et al. | Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12663372 |
| Monier S et al. | Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670484 |
| O'Sullivan AJ et al. | Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: modulatory effects of alpha- and gamma-tocopherol. | 2003 May-Jun | J Appl Toxicol | pmid:12794941 |
| Adachi J et al. | Consecutive administration of paraquat to rats induces enhanced cholesterol peroxidation and lung injury. | 2003 | Arch. Toxicol. | pmid:12799775 |
| Martin S et al. | Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. | 2003 | Br. J. Pharmacol. | pmid:12871827 |
| Adachi J et al. | 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle. | 2003 | Leg Med (Tokyo) | pmid:12935564 |
| Flader D et al. | Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil. | 2003 | Int J Vitam Nutr Res | pmid:12951900 |
| Petrón MJ et al. | Identification and quantification of cholesterol and cholesterol oxidation products in different types of Iberian hams. | 2003 | J. Agric. Food Chem. | pmid:12952434 |
| Meaney S et al. | On the origin of the cholestenoic acids in human circulation. | 2003 | Steroids | pmid:12957664 |