7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Micheletta F et al. | Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14592846 |
| Sato H et al. | Oxysterol regulation of estrogen receptor alpha-mediated gene expression in a transcriptional activation assay system using HeLa cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15322366 |
| Ryan L et al. | Generation of an oxidative stress precedes caspase activation during 7beta-hydroxycholesterol-induced apoptosis in U937 cells. | 2004 | J. Biochem. Mol. Toxicol. | pmid:14994280 |
| Schweizer RA et al. | Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. | 2004 | J. Biol. Chem. | pmid:14973125 |
| Hult M et al. | Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism. | 2004 | Cell. Mol. Life Sci. | pmid:15095019 |
| Kontush A et al. | Vitamin E is not deficient in human atherosclerotic plaques. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15237091 |
| O'Sullivan AJ et al. | Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: modulatory effects of alpha- and gamma-tocopherol. | 2003 May-Jun | J Appl Toxicol | pmid:12794941 |
| Maguire L et al. | Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7beta-hydroxycholesterol, in cultured mammalian cells. | 2003 | Br. J. Nutr. | pmid:13129445 |
| Meaney S et al. | On the origin of the cholestenoic acids in human circulation. | 2003 | Steroids | pmid:12957664 |
| Iuliano L et al. | Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status. | 2003 | Anal. Biochem. | pmid:12531208 |
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Flader D et al. | Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil. | 2003 | Int J Vitam Nutr Res | pmid:12951900 |
| Chang MY et al. | Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12663372 |
| Monier S et al. | Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670484 |
| Lim HK et al. | Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line. | 2003 | Life Sci. | pmid:12527036 |
| Martin S et al. | Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. | 2003 | Br. J. Pharmacol. | pmid:12871827 |
| Adachi J et al. | 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle. | 2003 | Leg Med (Tokyo) | pmid:12935564 |
| Ciuffreda P et al. | Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids. | 2003 | Steroids | pmid:14625005 |
| Adachi J et al. | Consecutive administration of paraquat to rats induces enhanced cholesterol peroxidation and lung injury. | 2003 | Arch. Toxicol. | pmid:12799775 |
| Petrón MJ et al. | Identification and quantification of cholesterol and cholesterol oxidation products in different types of Iberian hams. | 2003 | J. Agric. Food Chem. | pmid:12952434 |