Cantwell H and Devery R |
The response of the antioxidant defense system in rat hepatocytes challenged with oxysterols is modified by Covi-ox. |
1998 |
Cell Biol. Toxicol. |
pmid:9879932
|
Lemaire S et al. |
Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol. |
1998 |
FEBS Lett. |
pmid:9872417
|
Hwee Ming Cheng and Kalyana Sundram |
Cholesterol oxides and natural autoantibodies. |
1998 |
Atherosclerosis |
pmid:9862183
|
Lizard G et al. |
Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production. |
1998 |
FASEB J. |
pmid:9837855
|
Vine DF et al. |
Dietary oxysterols are incorporated in plasma triglyceride-rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits. |
1998 |
J. Lipid Res. |
pmid:9788246
|
Linseisen J and Wolfram G |
Absorption of cholesterol oxidation products from ordinary foodstuff in humans. |
1998 |
Ann. Nutr. Metab. |
pmid:9745108
|
Deckert V et al. |
Inhibition by cholesterol oxides of NO release from human vascular endothelial cells. |
1998 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:9672065
|
Dushkin M et al. |
Effects of oxysterols upon macrophage and lymphocyte functions in vitro. |
1998 |
Prostaglandins Other Lipid Mediat. |
pmid:9644113
|
Hakamata H et al. |
Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein. |
1998 |
J. Lipid Res. |
pmid:9548582
|
Pinchuk I et al. |
Kinetic analysis of copper-induced peroxidation of LDL. |
1998 |
Biochim. Biophys. Acta |
pmid:9461257
|
Lizard G et al. |
Induction of apoptosis and of interleukin-1beta secretion by 7beta-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression. |
1997 |
FEBS Lett. |
pmid:9428650
|
Lizard G et al. |
Induction of similar features of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol. |
1997 |
J. Pathol. |
pmid:9422990
|
Harada K et al. |
Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway. |
1997 |
FEBS Lett. |
pmid:9247143
|
Gesquière L et al. |
Impaired cellular cholesterol efflux by oxysterol-enriched high density lipoproteins. |
1997 |
Free Radic. Biol. Med. |
pmid:9215799
|
Tamasawa N et al. |
Reduction of oxysterol levels up-regulates HMG-CoA reductase activity in rat liver. |
1997 |
Atherosclerosis |
pmid:9199277
|
McCourt MP et al. |
X-ray crystal structure of cytotoxic oxidized cholesterols: 7-ketocholesterol and 25-hydroxycholesterol. |
1997 |
J. Lipid Res. |
pmid:9186918
|
Krut LH et al. |
The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells. |
1997 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:9108794
|
Dyer RG et al. |
7-ketocholesterol, a specific indicator of lipoprotein oxidation, and malondialdehyde in non-insulin dependent diabetes and peripheral vascular disease. |
1997 |
Clin. Chim. Acta |
pmid:9101096
|
Brown AJ et al. |
Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages. |
1996 |
J. Lipid Res. |
pmid:9026530
|
Deckert V et al. |
Inhibitors of arterial relaxation among components of human oxidized low-density lipoproteins. Cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation. |
1997 |
Circulation |
pmid:9024163
|
Ohtani K et al. |
Cytotoxicity of 7-ketocholesterol toward cultured rat hepatocytes and the effect of vitamin E. |
1996 |
Biosci. Biotechnol. Biochem. |
pmid:8988632
|
Patel RP et al. |
Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. |
1996 |
J. Lipid Res. |
pmid:8978488
|
Kritharides L et al. |
Hydroxypropyl-beta-cyclodextrin-mediated efflux of 7-ketocholesterol from macrophage foam cells. |
1996 |
J. Biol. Chem. |
pmid:8910326
|
Nishio E and Watanabe Y |
Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. |
1996 |
Biochem. Biophys. Res. Commun. |
pmid:8831713
|
Guyton JR et al. |
Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. |
1995 |
Atherosclerosis |
pmid:8770318
|
Pinchuk I and Lichtenberg D |
Continuous monitoring of intermediates and final products of oxidation of low density lipoprotein by means of UV-spectroscopy. |
1996 |
Free Radic. Res. |
pmid:8733939
|
Krut LH et al. |
Microscale preparation of natural and labeled oxysterols. |
1996 |
Lipids |
pmid:8727646
|
Nishio E et al. |
Oxidized LDL induces apoptosis in cultured smooth muscle cells: a possible role for 7-ketocholesterol. |
1996 |
Biochem. Biophys. Res. Commun. |
pmid:8670295
|
Gelissen IC et al. |
Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol. |
1996 |
J. Biol. Chem. |
pmid:8663356
|
Song W et al. |
Endogenous 7-oxocholesterol is an enzymatic product: characterization of 7 alpha-hydroxycholesterol dehydrogenase activity of hamster liver microsomes. |
1996 |
Arch. Biochem. Biophys. |
pmid:8645004
|
Palladini G et al. |
Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells. |
1996 |
Exp. Cell Res. |
pmid:8635498
|
Palladini G et al. |
Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. |
1996 |
Exp. Cell Res. |
pmid:8635497
|
Huggett CD et al. |
Plasma VLDL cholesterol and egg cholesterol are resistant to change in the laying hen. |
1993 |
Biochem. Soc. Trans. |
pmid:8359401
|
Breuer O et al. |
Cholesterol 7 alpha-hydroxylase is up-regulated by the competitive inhibitor 7-oxocholesterol in rat liver. |
1993 |
Eur. J. Biochem. |
pmid:8354276
|
Maor I and Aviram M |
Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester. |
1994 |
J. Lipid Res. |
pmid:8071603
|
Tamasawa N et al. |
The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7 alpha-hydroxylase activity in rat. |
1994 |
Biochim. Biophys. Acta |
pmid:8068724
|
Hughes H et al. |
Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. |
1994 |
Arterioscler. Thromb. |
pmid:8018675
|
Li QT and Das NP |
Comparison of the effects of cholesterol and oxysterols on phospholipid bilayer microheterogeneity: a study of fluorescence lifetime distributions. |
1994 |
Arch. Biochem. Biophys. |
pmid:7986094
|
Sevanian A et al. |
Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry. |
1994 |
Free Radic. Biol. Med. |
pmid:7835746
|
Axelson M et al. |
Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. |
1995 |
J. Lipid Res. |
pmid:7751816
|
Kritharides L et al. |
Apolipoprotein A-I-mediated efflux of sterols from oxidized LDL-loaded macrophages. |
1995 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:7749836
|
Maor I et al. |
Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol. |
1995 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:7670952
|
Breuer O and Björkhem I |
Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. |
1995 |
J. Biol. Chem. |
pmid:7657597
|
Sugiyama S et al. |
Lipoproteins regulate C-type natriuretic peptide secretion from cultured vascular endothelial cells. |
1995 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:7583578
|
Low YL and Hwang PL |
Lymphoma cells selected for resistance against the cytotoxic effect of oxygenated sterols are also resistant to nonsteroidal antiestrogens. |
1995 |
Biochim. Biophys. Acta |
pmid:7578268
|
Smith LL et al. |
Sterol metabolism--XLVII. Oxidized cholesterol esters in human tissues. |
1981 |
J. Steroid Biochem. |
pmid:7300357
|
Masuda A et al. |
Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein. |
1982 |
Mol. Cell. Biol. |
pmid:7162516
|
Williams JC et al. |
Defective catabolism of low-density lipoprotein by fibroblasts from patients with I-cell disease. |
1982 |
Biochem. J. |
pmid:7082306
|
Pratt HP et al. |
Membrane sterols and the development of the preimplantation mouse embryo. |
1980 |
J Embryol Exp Morphol |
pmid:7031162
|
Saito H et al. |
The regulating effect of cholesterol derivatives isolated from human sera on lymphocyte response to phytohemagglutinin. |
1983 |
Tohoku J. Exp. Med. |
pmid:6623455
|
Slotte JP et al. |
Uptake and esterification of exogenous cholesterol by low-density-lipoprotein-receptor-negative human fibroblasts in culture. |
1984 |
Biochem. J. |
pmid:6487273
|
Jeng I et al. |
Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. |
1985 |
Biochem. Pharmacol. |
pmid:3994747
|
Murphy PR et al. |
Binding of oxygenated cholesterol metabolites to antiestrogen binding sites from chicken liver. |
1985 |
Biochem. Biophys. Res. Commun. |
pmid:3985957
|
Gaspari AA and Rietschel RL |
Anti-inflammatory properties of an oxidized sterol. |
1985 |
J. Invest. Dermatol. |
pmid:3968446
|
Sevanian A and McLeod LL |
Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase. |
1986 |
J. Biol. Chem. |
pmid:3941086
|
Heiniger HJ et al. |
The role of cholesterol and its biosynthesis in lymphocyte proliferation and differentiation. |
1985 |
Ann. N. Y. Acad. Sci. |
pmid:3868313
|
Vargas RE et al. |
Effect of dietary 7-ketocholesterol, pure, or oxidized cholesterol on hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity, energy balance, egg cholesterol concentration, and 14C-acetate incorporation into yolk lipids of laying hens. |
1986 |
Poult. Sci. |
pmid:3748946
|
Ramachandran CK et al. |
Enhancement in the adhesion of tumor cells to endothelial cells by decreased cholesterol synthesis. |
1986 |
Cancer Res. |
pmid:3697991
|
Prome D et al. |
Conversion of sterols and triterpenes by mycobacteria. II. Transformation of 7-oxygenated sterols into androstane derivatives via a 7-deoxygenation. |
1987 |
Biochim. Biophys. Acta |
pmid:3663695
|
Björkhem I |
Assay of unesterified 7-oxocholesterol in human serum by isotope dilution-mass spectrometry. |
1986 |
Anal. Biochem. |
pmid:3524312
|
Parish EJ et al. |
A facile synthesis and carbon-13 nuclear magnetic resonance spectral properties of 7-ketocholesteryl benzoate. |
1987 |
Lipids |
pmid:3431349
|
Kosykh VA et al. |
7-ketocholesterol inhibits VLDL secretion by cultured human and rabbit hepatocytes. |
1988 |
Biochem. Biophys. Res. Commun. |
pmid:3390173
|
Beg ZH et al. |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone. |
1986 |
Arch. Biochem. Biophys. |
pmid:3004340
|
Cho HR et al. |
7-Oxygenated cholesterol molecules differentially affect the expression of zonula occludens-1 in vascular smooth muscle cells and monocyte/macrophage cells. |
2018 |
Biochem. Biophys. Res. Commun. |
pmid:29428726
|
Ghosh S et al. |
Cholesterol-oxidase-magnetic nanobioconjugates for the production of 4-cholesten-3-one and 4-cholesten-3, 7-dione. |
2018 |
Bioresour. Technol. |
pmid:29413944
|
Deiana M et al. |
Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. |
2017 |
Free Radic. Biol. Med. |
pmid:29102636
|
Tang HY et al. |
Lipidomics reveals accumulation of the oxidized cholesterol in erythrocytes of heart failure patients. |
2018 |
Redox Biol |
pmid:29101899
|
Badreddine A et al. |
Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N. |
2017 |
Int J Mol Sci |
pmid:29065513
|
Wnętrzak A et al. |
Oxysterols Versus Cholesterol in Model Neuronal Membrane. I. The Case of 7-Ketocholesterol. The Langmuir Monolayer Study. |
2017 |
J. Membr. Biol. |
pmid:28861595
|
Pyrshev KA et al. |
Caspase-3 activation decreases lipid order in the outer plasma membrane leaflet during apoptosis: A fluorescent probe study. |
2017 |
Biochim. Biophys. Acta |
pmid:28784460
|
Kim A et al. |
Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-κB activation-mediated cell death. |
2017 |
Brain Res. Bull. |
pmid:28710022
|
Rosa-Fernandes L et al. |
Outside-in, inside-out: Proteomic analysis of endothelial stress mediated by 7-ketocholesterol. |
2017 |
Chem. Phys. Lipids |
pmid:28663071
|
Koka S et al. |
Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia. |
2017 |
Redox Biol |
pmid:28633109
|
Wang Y et al. |
Mitochondrial Oxidative Stress Promotes Atherosclerosis and Neutrophil Extracellular Traps in Aged Mice. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:28596373
|
Ghosh S and Khare SK |
Biodegradation of 7-Ketocholesterol by Rhodococcus erythropolis MTCC 3951: Process optimization and enzymatic insights. |
2017 |
Chem. Phys. Lipids |
pmid:28571786
|
Wang M et al. |
Plasma 7-ketocholesterol levels and the risk of incident cardiovascular events. |
2017 |
Heart |
pmid:28490621
|
Debbabi M et al. |
Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells. |
2017 |
Chem. Phys. Lipids |
pmid:28408132
|
Song J et al. |
Association of Plasma 7-Ketocholesterol With Cardiovascular Outcomes and Total Mortality in Patients With Coronary Artery Disease. |
2017 |
Circ. Res. |
pmid:28381400
|
Ward LJ et al. |
Exposure to atheroma-relevant 7-oxysterols causes proteomic alterations in cell death, cellular longevity, and lipid metabolism in THP-1 macrophages. |
2017 |
PLoS ONE |
pmid:28350877
|
Cho HR et al. |
7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor. |
2017 |
PLoS ONE |
pmid:28323848
|
Bezine M et al. |
Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. |
2017 |
Chem. Phys. Lipids |
pmid:28322741
|
Musman J et al. |
Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. |
2016 |
Free Radic. Biol. Med. |
pmid:27989751
|
Debbabi M et al. |
Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells. |
2016 |
Int J Mol Sci |
pmid:27897980
|
Chang MC et al. |
7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells. |
2016 |
Oncotarget |
pmid:27740938
|
Pang C et al. |
Biotransformation of cholesterol and 16,17-alpha epoxypregnenolone by novel Cladosporium sp. strain IS547. |
2017 |
J. Basic Microbiol. |
pmid:27690325
|
Rosa Fernandes L et al. |
7-Ketocholesterol overcomes drug resistance in chronic myeloid leukemia cell lines beyond MDR1 mechanism. |
2017 |
J Proteomics |
pmid:27343758
|
Sanda GM et al. |
Oxidized LDL-Exposed Human Macrophages Display Increased MMP-9 Expression and Secretion Mediated by Endoplasmic Reticulum Stress. |
2017 |
J. Cell. Biochem. |
pmid:27341688
|
Zhan X et al. |
[Blood 7-ketocholesterol level, clinical features and gene mutation analysis of 18 children with Niemann-Pick disease type C]. |
2016 |
Zhonghua Er Ke Za Zhi |
pmid:27256227
|
Silva SF et al. |
Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:27133385
|
Nury T et al. |
7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:27041118
|
Leoni V et al. |
Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:27020660
|
Ghosh S and Khare SK |
Biodegradation of cytotoxic 7-Ketocholesterol by Pseudomonas aeruginosa PseA. |
2016 |
Bioresour. Technol. |
pmid:27020128
|
Tran J et al. |
Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells. |
2016 |
PLoS ONE |
pmid:26977592
|
Zarrouk A et al. |
Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:26921765
|
Romanello M et al. |
Comprehensive Evaluation of Plasma 7-Ketocholesterol and Cholestan-3β,5α,6β-Triol in an Italian Cohort of Patients Affected by Niemann-Pick Disease due to NPC1 and SMPD1 Mutations. |
2016 |
Clin. Chim. Acta |
pmid:26790753
|
Boenzi S et al. |
Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism. |
2016 |
J. Lipid Res. |
pmid:26733147
|
Alba G et al. |
7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils. |
2016 |
Eur J Nutr |
pmid:26715521
|
Gajewski A et al. |
Helicobacter pylori antigens, acetylsalicylic acid, LDL and 7-ketocholesterol - their potential role in destabilizing the gastric epithelial cell barrier. An in vitro model of Kato III cells. |
2016 |
Acta Biochim. Pol. |
pmid:26619253
|
Pataj Z et al. |
Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. |
2016 |
J Chromatogr A |
pmid:26607314
|
Rasmiena AA et al. |
High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein. |
2016 |
Biochim. Biophys. Acta |
pmid:26569052
|