7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim A et al. | Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-κB activation-mediated cell death. | 2017 | Brain Res. Bull. | pmid:28710022 |
| Pyrshev KA et al. | Caspase-3 activation decreases lipid order in the outer plasma membrane leaflet during apoptosis: A fluorescent probe study. | 2017 | Biochim. Biophys. Acta | pmid:28784460 |
| Wnętrzak A et al. | Oxysterols Versus Cholesterol in Model Neuronal Membrane. I. The Case of 7-Ketocholesterol. The Langmuir Monolayer Study. | 2017 | J. Membr. Biol. | pmid:28861595 |
| Badreddine A et al. | Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N. | 2017 | Int J Mol Sci | pmid:29065513 |
| Tang HY et al. | Lipidomics reveals accumulation of the oxidized cholesterol in erythrocytes of heart failure patients. | 2018 | Redox Biol | pmid:29101899 |
| Deiana M et al. | Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. | 2017 | Free Radic. Biol. Med. | pmid:29102636 |
| Ghosh S et al. | Cholesterol-oxidase-magnetic nanobioconjugates for the production of 4-cholesten-3-one and 4-cholesten-3, 7-dione. | 2018 | Bioresour. Technol. | pmid:29413944 |
| Cho HR et al. | 7-Oxygenated cholesterol molecules differentially affect the expression of zonula occludens-1 in vascular smooth muscle cells and monocyte/macrophage cells. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29428726 |
| Beg ZH et al. | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone. | 1986 | Arch. Biochem. Biophys. | pmid:3004340 |
| Kosykh VA et al. | 7-ketocholesterol inhibits VLDL secretion by cultured human and rabbit hepatocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3390173 |
| Parish EJ et al. | A facile synthesis and carbon-13 nuclear magnetic resonance spectral properties of 7-ketocholesteryl benzoate. | 1987 | Lipids | pmid:3431349 |
| Björkhem I | Assay of unesterified 7-oxocholesterol in human serum by isotope dilution-mass spectrometry. | 1986 | Anal. Biochem. | pmid:3524312 |
| Prome D et al. | Conversion of sterols and triterpenes by mycobacteria. II. Transformation of 7-oxygenated sterols into androstane derivatives via a 7-deoxygenation. | 1987 | Biochim. Biophys. Acta | pmid:3663695 |
| Ramachandran CK et al. | Enhancement in the adhesion of tumor cells to endothelial cells by decreased cholesterol synthesis. | 1986 | Cancer Res. | pmid:3697991 |
| Vargas RE et al. | Effect of dietary 7-ketocholesterol, pure, or oxidized cholesterol on hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity, energy balance, egg cholesterol concentration, and 14C-acetate incorporation into yolk lipids of laying hens. | 1986 | Poult. Sci. | pmid:3748946 |
| Heiniger HJ et al. | The role of cholesterol and its biosynthesis in lymphocyte proliferation and differentiation. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3868313 |
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| Gaspari AA and Rietschel RL | Anti-inflammatory properties of an oxidized sterol. | 1985 | J. Invest. Dermatol. | pmid:3968446 |
| Murphy PR et al. | Binding of oxygenated cholesterol metabolites to antiestrogen binding sites from chicken liver. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3985957 |
| Jeng I et al. | Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. | 1985 | Biochem. Pharmacol. | pmid:3994747 |
| Slotte JP et al. | Uptake and esterification of exogenous cholesterol by low-density-lipoprotein-receptor-negative human fibroblasts in culture. | 1984 | Biochem. J. | pmid:6487273 |
| Saito H et al. | The regulating effect of cholesterol derivatives isolated from human sera on lymphocyte response to phytohemagglutinin. | 1983 | Tohoku J. Exp. Med. | pmid:6623455 |
| Pratt HP et al. | Membrane sterols and the development of the preimplantation mouse embryo. | 1980 | J Embryol Exp Morphol | pmid:7031162 |
| Williams JC et al. | Defective catabolism of low-density lipoprotein by fibroblasts from patients with I-cell disease. | 1982 | Biochem. J. | pmid:7082306 |
| Masuda A et al. | Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein. | 1982 | Mol. Cell. Biol. | pmid:7162516 |
| Smith LL et al. | Sterol metabolism--XLVII. Oxidized cholesterol esters in human tissues. | 1981 | J. Steroid Biochem. | pmid:7300357 |
| Low YL and Hwang PL | Lymphoma cells selected for resistance against the cytotoxic effect of oxygenated sterols are also resistant to nonsteroidal antiestrogens. | 1995 | Biochim. Biophys. Acta | pmid:7578268 |
| Sugiyama S et al. | Lipoproteins regulate C-type natriuretic peptide secretion from cultured vascular endothelial cells. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7583578 |
| Breuer O and Björkhem I | Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. | 1995 | J. Biol. Chem. | pmid:7657597 |
| Maor I et al. | Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7670952 |
| Kritharides L et al. | Apolipoprotein A-I-mediated efflux of sterols from oxidized LDL-loaded macrophages. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7749836 |
| Axelson M et al. | Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. | 1995 | J. Lipid Res. | pmid:7751816 |
| Sevanian A et al. | Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry. | 1994 | Free Radic. Biol. Med. | pmid:7835746 |
| Li QT and Das NP | Comparison of the effects of cholesterol and oxysterols on phospholipid bilayer microheterogeneity: a study of fluorescence lifetime distributions. | 1994 | Arch. Biochem. Biophys. | pmid:7986094 |
| Hughes H et al. | Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. | 1994 | Arterioscler. Thromb. | pmid:8018675 |
| Tamasawa N et al. | The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7 alpha-hydroxylase activity in rat. | 1994 | Biochim. Biophys. Acta | pmid:8068724 |
| Maor I and Aviram M | Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester. | 1994 | J. Lipid Res. | pmid:8071603 |
| Breuer O et al. | Cholesterol 7 alpha-hydroxylase is up-regulated by the competitive inhibitor 7-oxocholesterol in rat liver. | 1993 | Eur. J. Biochem. | pmid:8354276 |
| Huggett CD et al. | Plasma VLDL cholesterol and egg cholesterol are resistant to change in the laying hen. | 1993 | Biochem. Soc. Trans. | pmid:8359401 |
| Palladini G et al. | Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635497 |
| Palladini G et al. | Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635498 |
| Song W et al. | Endogenous 7-oxocholesterol is an enzymatic product: characterization of 7 alpha-hydroxycholesterol dehydrogenase activity of hamster liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8645004 |
| Gelissen IC et al. | Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol. | 1996 | J. Biol. Chem. | pmid:8663356 |
| Nishio E et al. | Oxidized LDL induces apoptosis in cultured smooth muscle cells: a possible role for 7-ketocholesterol. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8670295 |
| Krut LH et al. | Microscale preparation of natural and labeled oxysterols. | 1996 | Lipids | pmid:8727646 |
| Pinchuk I and Lichtenberg D | Continuous monitoring of intermediates and final products of oxidation of low density lipoprotein by means of UV-spectroscopy. | 1996 | Free Radic. Res. | pmid:8733939 |
| Guyton JR et al. | Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. | 1995 | Atherosclerosis | pmid:8770318 |
| Nishio E and Watanabe Y | Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8831713 |
| Kritharides L et al. | Hydroxypropyl-beta-cyclodextrin-mediated efflux of 7-ketocholesterol from macrophage foam cells. | 1996 | J. Biol. Chem. | pmid:8910326 |
| Patel RP et al. | Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. | 1996 | J. Lipid Res. | pmid:8978488 |