|
|
|
|
pmid:
|
Cox RH and Spencer EY |
The Effect of 7-Ketocholesterol on the Rabbit. |
1949 |
Science |
pmid:17753811
|
ROSENKRANTZ H and GUT M |
Hydrogen bonding in 7-ketocholesterol and a new isomorph of 7-ketocholesteryl acetate. |
1954 |
Science |
pmid:13216220
|
Van Cantfort J and Gielen J |
Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro. |
1975 |
Eur. J. Biochem. |
pmid:1175606
|
Pratt HP et al. |
Membrane sterols and the development of the preimplantation mouse embryo. |
1980 |
J Embryol Exp Morphol |
pmid:7031162
|
Smith LL et al. |
Sterol metabolism--XLVII. Oxidized cholesterol esters in human tissues. |
1981 |
J. Steroid Biochem. |
pmid:7300357
|
Williams JC et al. |
Defective catabolism of low-density lipoprotein by fibroblasts from patients with I-cell disease. |
1982 |
Biochem. J. |
pmid:7082306
|
Masuda A et al. |
Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein. |
1982 |
Mol. Cell. Biol. |
pmid:7162516
|
Saito H et al. |
The regulating effect of cholesterol derivatives isolated from human sera on lymphocyte response to phytohemagglutinin. |
1983 |
Tohoku J. Exp. Med. |
pmid:6623455
|
Slotte JP et al. |
Uptake and esterification of exogenous cholesterol by low-density-lipoprotein-receptor-negative human fibroblasts in culture. |
1984 |
Biochem. J. |
pmid:6487273
|
Heiniger HJ et al. |
The role of cholesterol and its biosynthesis in lymphocyte proliferation and differentiation. |
1985 |
Ann. N. Y. Acad. Sci. |
pmid:3868313
|
Gaspari AA and Rietschel RL |
Anti-inflammatory properties of an oxidized sterol. |
1985 |
J. Invest. Dermatol. |
pmid:3968446
|
Jeng I et al. |
Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. |
1985 |
Biochem. Pharmacol. |
pmid:3994747
|
Murphy PR et al. |
Binding of oxygenated cholesterol metabolites to antiestrogen binding sites from chicken liver. |
1985 |
Biochem. Biophys. Res. Commun. |
pmid:3985957
|
Ramachandran CK et al. |
Enhancement in the adhesion of tumor cells to endothelial cells by decreased cholesterol synthesis. |
1986 |
Cancer Res. |
pmid:3697991
|
Vargas RE et al. |
Effect of dietary 7-ketocholesterol, pure, or oxidized cholesterol on hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity, energy balance, egg cholesterol concentration, and 14C-acetate incorporation into yolk lipids of laying hens. |
1986 |
Poult. Sci. |
pmid:3748946
|
Beg ZH et al. |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone. |
1986 |
Arch. Biochem. Biophys. |
pmid:3004340
|
Sevanian A and McLeod LL |
Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase. |
1986 |
J. Biol. Chem. |
pmid:3941086
|
Björkhem I |
Assay of unesterified 7-oxocholesterol in human serum by isotope dilution-mass spectrometry. |
1986 |
Anal. Biochem. |
pmid:3524312
|
Parish EJ et al. |
A facile synthesis and carbon-13 nuclear magnetic resonance spectral properties of 7-ketocholesteryl benzoate. |
1987 |
Lipids |
pmid:3431349
|
Prome D et al. |
Conversion of sterols and triterpenes by mycobacteria. II. Transformation of 7-oxygenated sterols into androstane derivatives via a 7-deoxygenation. |
1987 |
Biochim. Biophys. Acta |
pmid:3663695
|
Kosykh VA et al. |
7-ketocholesterol inhibits VLDL secretion by cultured human and rabbit hepatocytes. |
1988 |
Biochem. Biophys. Res. Commun. |
pmid:3390173
|
Hwang PL |
High-affinity binding sites for oxygenated sterols in rat liver microsomes: possible identity with antiestrogen binding sites. |
1990 |
Biochim. Biophys. Acta |
pmid:2306459
|
Beriozov AT et al. |
Cholesterol oxidation on fluorocarbon emulsion surface leads to the formation of 7-peroxycholesterol. |
1990 |
FEBS Lett. |
pmid:2365071
|
Lahoua Z et al. |
Oxysterol activation of arachidonic acid release and prostaglandin E2 biosynthesis in NRK 49F cells is partially dependent on protein kinase C activity [corrected]. |
1991 |
Cell. Signal. |
pmid:1786206
|
Soejima S et al. |
Hyperthermic sensitivity and cholesterol levels of mammalian cell lines in culture. |
1991 |
Cancer Lett. |
pmid:1933839
|
Khokhlov AN et al. |
Effects of cholesterol- or 7-ketocholesterol-containing liposomes on colony-forming ability of cultured cells. |
1991 |
FEBS Lett. |
pmid:1915871
|
Jialal I et al. |
Varying susceptibility of different low density lipoproteins to oxidative modification. |
1991 May-Jun |
Arterioscler. Thromb. |
pmid:2029490
|
Tamasawa N and Takebe K |
Analytical examination of oxidized free and esterified 7-ketocholesterol and related oxysterols in human plasma incubated with copper. |
1992 |
Tohoku J. Exp. Med. |
pmid:1488757
|
Kupferberg A et al. |
Separation and purification of dolichol and dolichyl phosphate by anion-exchange paper chromatography: application to cultured cells. |
1992 |
Anal. Biochem. |
pmid:1443591
|
Dorset DL |
Binary phase behavior of angiotoxic oxidized cholesterols with cholesterol. |
1992 |
Biochim. Biophys. Acta |
pmid:1511006
|
Hwang PL |
Inhibitors of protein and RNA synthesis block the cytotoxic effects of oxygenated sterols. |
1992 |
Biochim. Biophys. Acta |
pmid:1379472
|
Breuer O et al. |
Cholesterol 7 alpha-hydroxylase is up-regulated by the competitive inhibitor 7-oxocholesterol in rat liver. |
1993 |
Eur. J. Biochem. |
pmid:8354276
|
Huggett CD et al. |
Plasma VLDL cholesterol and egg cholesterol are resistant to change in the laying hen. |
1993 |
Biochem. Soc. Trans. |
pmid:8359401
|
Hughes H et al. |
Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. |
1994 |
Arterioscler. Thromb. |
pmid:8018675
|
Sevanian A et al. |
Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry. |
1994 |
Free Radic. Biol. Med. |
pmid:7835746
|
Maor I and Aviram M |
Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester. |
1994 |
J. Lipid Res. |
pmid:8071603
|
Li QT and Das NP |
Comparison of the effects of cholesterol and oxysterols on phospholipid bilayer microheterogeneity: a study of fluorescence lifetime distributions. |
1994 |
Arch. Biochem. Biophys. |
pmid:7986094
|
Tamasawa N et al. |
The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7 alpha-hydroxylase activity in rat. |
1994 |
Biochim. Biophys. Acta |
pmid:8068724
|
Low YL and Hwang PL |
Lymphoma cells selected for resistance against the cytotoxic effect of oxygenated sterols are also resistant to nonsteroidal antiestrogens. |
1995 |
Biochim. Biophys. Acta |
pmid:7578268
|
Sugiyama S et al. |
Lipoproteins regulate C-type natriuretic peptide secretion from cultured vascular endothelial cells. |
1995 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:7583578
|
Guyton JR et al. |
Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. |
1995 |
Atherosclerosis |
pmid:8770318
|
Maor I et al. |
Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol. |
1995 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:7670952
|
Axelson M et al. |
Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. |
1995 |
J. Lipid Res. |
pmid:7751816
|
Breuer O and Björkhem I |
Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. |
1995 |
J. Biol. Chem. |
pmid:7657597
|
Kritharides L et al. |
Apolipoprotein A-I-mediated efflux of sterols from oxidized LDL-loaded macrophages. |
1995 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:7749836
|
Song W et al. |
Endogenous 7-oxocholesterol is an enzymatic product: characterization of 7 alpha-hydroxycholesterol dehydrogenase activity of hamster liver microsomes. |
1996 |
Arch. Biochem. Biophys. |
pmid:8645004
|
Pinchuk I and Lichtenberg D |
Continuous monitoring of intermediates and final products of oxidation of low density lipoprotein by means of UV-spectroscopy. |
1996 |
Free Radic. Res. |
pmid:8733939
|
Ohtani K et al. |
Cytotoxicity of 7-ketocholesterol toward cultured rat hepatocytes and the effect of vitamin E. |
1996 |
Biosci. Biotechnol. Biochem. |
pmid:8988632
|
Gelissen IC et al. |
Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol. |
1996 |
J. Biol. Chem. |
pmid:8663356
|
Palladini G et al. |
Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. |
1996 |
Exp. Cell Res. |
pmid:8635497
|
Palladini G et al. |
Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells. |
1996 |
Exp. Cell Res. |
pmid:8635498
|
Patel RP et al. |
Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. |
1996 |
J. Lipid Res. |
pmid:8978488
|
Nishio E et al. |
Oxidized LDL induces apoptosis in cultured smooth muscle cells: a possible role for 7-ketocholesterol. |
1996 |
Biochem. Biophys. Res. Commun. |
pmid:8670295
|
Nishio E and Watanabe Y |
Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. |
1996 |
Biochem. Biophys. Res. Commun. |
pmid:8831713
|
Brown AJ et al. |
Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages. |
1996 |
J. Lipid Res. |
pmid:9026530
|
Krut LH et al. |
Microscale preparation of natural and labeled oxysterols. |
1996 |
Lipids |
pmid:8727646
|
Kritharides L et al. |
Hydroxypropyl-beta-cyclodextrin-mediated efflux of 7-ketocholesterol from macrophage foam cells. |
1996 |
J. Biol. Chem. |
pmid:8910326
|
Harada K et al. |
Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway. |
1997 |
FEBS Lett. |
pmid:9247143
|
Gesquière L et al. |
Impaired cellular cholesterol efflux by oxysterol-enriched high density lipoproteins. |
1997 |
Free Radic. Biol. Med. |
pmid:9215799
|
Krut LH et al. |
The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells. |
1997 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:9108794
|
Lizard G et al. |
Induction of similar features of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol. |
1997 |
J. Pathol. |
pmid:9422990
|
Dyer RG et al. |
7-ketocholesterol, a specific indicator of lipoprotein oxidation, and malondialdehyde in non-insulin dependent diabetes and peripheral vascular disease. |
1997 |
Clin. Chim. Acta |
pmid:9101096
|
Lizard G et al. |
Induction of apoptosis and of interleukin-1beta secretion by 7beta-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression. |
1997 |
FEBS Lett. |
pmid:9428650
|
Deckert V et al. |
Inhibitors of arterial relaxation among components of human oxidized low-density lipoproteins. Cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation. |
1997 |
Circulation |
pmid:9024163
|
Tamasawa N et al. |
Reduction of oxysterol levels up-regulates HMG-CoA reductase activity in rat liver. |
1997 |
Atherosclerosis |
pmid:9199277
|
Zhang Q et al. |
[Quantitative determination of 7-ketocholesterol in human fetal liver cell supernatant and lysate by high performance liquid chromatography]. |
1997 |
Se Pu |
pmid:15739446
|
McCourt MP et al. |
X-ray crystal structure of cytotoxic oxidized cholesterols: 7-ketocholesterol and 25-hydroxycholesterol. |
1997 |
J. Lipid Res. |
pmid:9186918
|
Vine DF et al. |
Dietary oxysterols are incorporated in plasma triglyceride-rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits. |
1998 |
J. Lipid Res. |
pmid:9788246
|
Hakamata H et al. |
Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein. |
1998 |
J. Lipid Res. |
pmid:9548582
|
Cantwell H and Devery R |
The response of the antioxidant defense system in rat hepatocytes challenged with oxysterols is modified by Covi-ox. |
1998 |
Cell Biol. Toxicol. |
pmid:9879932
|
Lizard G et al. |
Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production. |
1998 |
FASEB J. |
pmid:9837855
|
Lemaire S et al. |
Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol. |
1998 |
FEBS Lett. |
pmid:9872417
|
Dushkin M et al. |
Effects of oxysterols upon macrophage and lymphocyte functions in vitro. |
1998 |
Prostaglandins Other Lipid Mediat. |
pmid:9644113
|
Hakamata H et al. |
Cytotoxic effect of oxidized low density lipoprotein on macrophages. |
1998 |
J. Atheroscler. Thromb. |
pmid:10855560
|
Pinchuk I et al. |
Kinetic analysis of copper-induced peroxidation of LDL. |
1998 |
Biochim. Biophys. Acta |
pmid:9461257
|
Hwee Ming Cheng and Kalyana Sundram |
Cholesterol oxides and natural autoantibodies. |
1998 |
Atherosclerosis |
pmid:9862183
|
Linseisen J and Wolfram G |
Absorption of cholesterol oxidation products from ordinary foodstuff in humans. |
1998 |
Ann. Nutr. Metab. |
pmid:9745108
|
Deckert V et al. |
Inhibition by cholesterol oxides of NO release from human vascular endothelial cells. |
1998 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:9672065
|
Myers SJ and Stanley KK |
Src family kinase activation in glycosphingolipid-rich membrane domains of endothelial cells treated with oxidised low density lipoprotein. |
1999 |
Atherosclerosis |
pmid:10217369
|
van Reyk DM et al. |
Prooxidant and antioxidant activities of macrophages in metal-mediated LDL oxidation: the importance of metal sequestration. |
1999 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:10195944
|
Zarev S et al. |
Major differences in oxysterol formation in human low density lipoproteins (LDLs) oxidized by *OH/O2*- free radicals or by copper. |
1999 |
FEBS Lett. |
pmid:10371147
|
Gelissen IC et al. |
Oxysterol efflux from macrophage foam cells: the essential role of acceptor phospholipid. |
1999 |
J. Lipid Res. |
pmid:10484610
|
Urano Y et al. |
Vascular smooth muscle cell outgrowth, proliferation, and apoptosis in young and old rats. |
1999 |
Atherosclerosis |
pmid:10487492
|
Lizard G et al. |
Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. |
1999 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:10323769
|
Pirillo A et al. |
Oxysterols from oxidized LDL are cytotoxic but fail to induce hsp70 expression in endothelial cells. |
1999 |
FEBS Lett. |
pmid:10580102
|
Inouye M et al. |
Glycated hemoglobin and lipid peroxidation in erythrocytes of diabetic patients. |
1999 |
Metab. Clin. Exp. |
pmid:10024083
|
Rao ML et al. |
Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides. |
1999 |
Ann. N. Y. Acad. Sci. |
pmid:10672272
|
Lyons MA et al. |
Rapid hepatic metabolism of 7-ketocholesterol in vivo: implications for dietary oxysterols. |
1999 |
J. Lipid Res. |
pmid:10508204
|
Lyons MA and Brown AJ |
7-Ketocholesterol. |
1999 Mar-Apr |
Int. J. Biochem. Cell Biol. |
pmid:10224662
|
Norlin M et al. |
24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). |
2000 |
J. Lipid Res. |
pmid:11013305
|
Brown AJ et al. |
Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes. |
2000 |
J. Lipid Res. |
pmid:10681406
|
Bourdon E et al. |
Involvement of oxysterols and lysophosphatidylcholine in the oxidized LDL-induced impairment of serum albumin synthesis by HEPG2 cells. |
2000 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:11116066
|
Lizard G et al. |
Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis. |
2000 |
Free Radic. Biol. Med. |
pmid:10754270
|
Abo K et al. |
Comparative analysis of plasma and erythrocyte 7-ketocholesterol as a marker for oxidative stress in patients with diabetes mellitus. |
2000 |
Clin. Biochem. |
pmid:11124339
|
Perségol L et al. |
Co-incubation of native and oxidized low-density lipoproteins: potentiation of relaxation impairment. |
2000 |
Eur. J. Pharmacol. |
pmid:11040350
|
Liao HS et al. |
Expression of class A scavenger receptor inhibits apoptosis of macrophages triggered by oxidized low density lipoprotein and oxysterol. |
2000 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:10938019
|
Brown AJ et al. |
Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture. |
2000 |
J. Biol. Chem. |
pmid:10869358
|
Yoshida T et al. |
Cholestan-3beta,5alpha,6beta-triol, but not 7-ketocholesterol, suppresses taurocholate-induced mucin secretion by cultured dog gallbladder epithelial cells. |
2000 |
FEBS Lett. |
pmid:10922480
|
Tsuzuki D et al. |
Analysis of 7-ketocholesterol in low density lipoprotein and fatty acid composition in erythrocyte membranes of patients on maintenance hemodialysis and healthy controls. |
2000 |
Clin. Chim. Acta |
pmid:10767401
|