7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Huang Z et al. | 7-ketocholesterol induces cell apoptosis by activation of nuclear factor kappa B in mouse macrophages. | 2010 | Acta Med. Okayama | pmid:20424663 |
| Catarino S et al. | Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells. | 2012 | Acta Ophthalmol | pmid:22313893 |
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| Beg ZH et al. | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone. | 1986 | Arch. Biochem. Biophys. | pmid:3004340 |
| Ghelli A et al. | 7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells. | 2002 | Arch. Biochem. Biophys. | pmid:12051665 |
| Li QT and Das NP | Comparison of the effects of cholesterol and oxysterols on phospholipid bilayer microheterogeneity: a study of fluorescence lifetime distributions. | 1994 | Arch. Biochem. Biophys. | pmid:7986094 |
| Liu J et al. | Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol. | 2009 | Arch. Biochem. Biophys. | pmid:19464253 |
| Adachi J et al. | Consecutive administration of paraquat to rats induces enhanced cholesterol peroxidation and lung injury. | 2003 | Arch. Toxicol. | pmid:12799775 |
| Hughes H et al. | Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. | 1994 | Arterioscler. Thromb. | pmid:8018675 |
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| Maor I et al. | Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7670952 |
| Lizard G et al. | Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10323769 |
| Bourdon E et al. | Involvement of oxysterols and lysophosphatidylcholine in the oxidized LDL-induced impairment of serum albumin synthesis by HEPG2 cells. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11116066 |
| Chang MY et al. | Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12663372 |
| Liao HS et al. | Expression of class A scavenger receptor inhibits apoptosis of macrophages triggered by oxidized low density lipoprotein and oxysterol. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10938019 |
| Rosenblat M et al. | Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615656 |
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| Wang Y et al. | Mitochondrial Oxidative Stress Promotes Atherosclerosis and Neutrophil Extracellular Traps in Aged Mice. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28596373 |
| Deckert V et al. | Inhibition by cholesterol oxides of NO release from human vascular endothelial cells. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9672065 |
| Martinet W et al. | 7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15458974 |
| Phillips JE et al. | 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells. | 2001 | Atherosclerosis | pmid:11689214 |