7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Matsunaga I et al. | Determination of oxysterols in oxidatively modified low-density lipoprotein by semi-micro high-performance liquid chromatography with electrochemical detection. | 2009 | Anal. Biochem. | pmid:19563770 |
| Björkhem I | Assay of unesterified 7-oxocholesterol in human serum by isotope dilution-mass spectrometry. | 1986 | Anal. Biochem. | pmid:3524312 |
| Kahn E et al. | FRET multiphoton spectral imaging microscopy of 7-ketocholesterol and Nile Red in U937 monocytic cells loaded with 7-ketocholesterol. | 2004 | Anal. Quant. Cytol. Histol. | pmid:15678612 |
| Kahn E et al. | Analysis of the fluorescence of monodansylcadaverine-positive cytoplasmic structures during 7-ketocholesterol-induced cell death. | 2004 | Anal. Quant. Cytol. Histol. | pmid:15032081 |
| Kahn E et al. | Analysis of the capture and influence of nanoparticles on the cytotoxic effects of 7-ketocholesterol on cardiac cells: investigation by flow cytometry and by dynamic and spectral imaging microscopy associated with factor analysis of medical image sequences. | 2009 | Anal. Quant. Cytol. Histol. | pmid:20698354 |
| Kahn E et al. | Flow cytometry and spectral imaging multiphoton microscopy analysis of CD36 expression with quantum dots 605 of untreated and 7-ketocholesterol-treated human monocytic cells. | 2006 | Anal. Quant. Cytol. Histol. | pmid:17220145 |
| Kahn E et al. | Flow cytometry and factor analysis evaluation of confocal image sequences of morphologic and functional changes occurring at the mitochondrial level during 7-ketocholesterol-induced cell death. | 2002 | Anal. Quant. Cytol. Histol. | pmid:12508695 |
| Heiniger HJ et al. | The role of cholesterol and its biosynthesis in lymphocyte proliferation and differentiation. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3868313 |
| Rao ML et al. | Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10672272 |
| Linseisen J and Wolfram G | Absorption of cholesterol oxidation products from ordinary foodstuff in humans. | 1998 | Ann. Nutr. Metab. | pmid:9745108 |