7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ohtani K et al. | Cytotoxicity of 7-ketocholesterol toward cultured rat hepatocytes and the effect of vitamin E. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8988632 |
| Patel RP et al. | Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. | 1996 | J. Lipid Res. | pmid:8978488 |
| Kritharides L et al. | Hydroxypropyl-beta-cyclodextrin-mediated efflux of 7-ketocholesterol from macrophage foam cells. | 1996 | J. Biol. Chem. | pmid:8910326 |
| Nishio E and Watanabe Y | Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8831713 |
| Guyton JR et al. | Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. | 1995 | Atherosclerosis | pmid:8770318 |
| Pinchuk I and Lichtenberg D | Continuous monitoring of intermediates and final products of oxidation of low density lipoprotein by means of UV-spectroscopy. | 1996 | Free Radic. Res. | pmid:8733939 |
| Krut LH et al. | Microscale preparation of natural and labeled oxysterols. | 1996 | Lipids | pmid:8727646 |
| Nishio E et al. | Oxidized LDL induces apoptosis in cultured smooth muscle cells: a possible role for 7-ketocholesterol. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8670295 |
| Gelissen IC et al. | Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol. | 1996 | J. Biol. Chem. | pmid:8663356 |
| Song W et al. | Endogenous 7-oxocholesterol is an enzymatic product: characterization of 7 alpha-hydroxycholesterol dehydrogenase activity of hamster liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8645004 |
| Palladini G et al. | Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635498 |
| Palladini G et al. | Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635497 |
| Huggett CD et al. | Plasma VLDL cholesterol and egg cholesterol are resistant to change in the laying hen. | 1993 | Biochem. Soc. Trans. | pmid:8359401 |
| Breuer O et al. | Cholesterol 7 alpha-hydroxylase is up-regulated by the competitive inhibitor 7-oxocholesterol in rat liver. | 1993 | Eur. J. Biochem. | pmid:8354276 |
| Maor I and Aviram M | Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester. | 1994 | J. Lipid Res. | pmid:8071603 |
| Tamasawa N et al. | The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7 alpha-hydroxylase activity in rat. | 1994 | Biochim. Biophys. Acta | pmid:8068724 |
| Hughes H et al. | Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. | 1994 | Arterioscler. Thromb. | pmid:8018675 |
| Li QT and Das NP | Comparison of the effects of cholesterol and oxysterols on phospholipid bilayer microheterogeneity: a study of fluorescence lifetime distributions. | 1994 | Arch. Biochem. Biophys. | pmid:7986094 |
| Sevanian A et al. | Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry. | 1994 | Free Radic. Biol. Med. | pmid:7835746 |
| Axelson M et al. | Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. | 1995 | J. Lipid Res. | pmid:7751816 |