7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mahfouz M and Kummerow F | Oxidized low density lipoprotein inhibits prostacyclin generation by rat aorta in vitro: a key role of lysolecithin. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785781 |
| Hayden JM et al. | Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. | 2002 | J. Lipid Res. | pmid:11792719 |
| Meynier A et al. | Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters. | 2002 | Br. J. Nutr. | pmid:12010578 |
| Lyons MA et al. | Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice. | 2002 | Biochim. Biophys. Acta | pmid:12020639 |
| Tomoyori H et al. | Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036056 |
| Fujita T et al. | Chronic ethanol feeding increases 7-hydroperoxycholesterol and oxysterols in rat skeletal muscle. | 2002 | Metab. Clin. Exp. | pmid:12037727 |
| Ghelli A et al. | 7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells. | 2002 | Arch. Biochem. Biophys. | pmid:12051665 |
| Kim JW et al. | Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro. | 2002 | Exp. Mol. Med. | pmid:12085989 |
| Zwirska-Korczala K et al. | [Assessment of plasma lipid profile oxysterols and vitamin E concentration in morbidity obese patients with coexisting arterial hypertension and non-insulin dependent diabetes mellitus]. | 2002 | Pol. Arch. Med. Wewn. | pmid:12107969 |
| Maeda Y et al. | A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken. | 2002 | Steroids | pmid:12117617 |
| Gregorio-King CC et al. | Effect of oxysterols on hematopoietic progenitor cells. | 2002 | Exp. Hematol. | pmid:12135663 |
| Miguet-Alfonsi C et al. | Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. | 2002 | Biochem. Pharmacol. | pmid:12147305 |
| Fainaru O et al. | Active labour is associated with increased oxidisibility of serum lipids ex vivo. | 2002 | BJOG | pmid:12197375 |
| Deckert V et al. | Prevention of LDL alpha-tocopherol consumption, cholesterol oxidation, and vascular endothelium dysfunction by polyphenolic compounds from red wine. | 2002 | Atherosclerosis | pmid:12208469 |
| Liu Q et al. | Omega-carboxyl variants of 7-ketocholesteryl esters are ligands for beta(2)-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages. | 2002 | J. Lipid Res. | pmid:12235181 |
| Oyama T et al. | Effect of deposited lipids in atheromatous lesions on the migration of vascular smooth muscle cells. | 2002 | J. Atheroscler. Thromb. | pmid:12236314 |
| Miyashita Y et al. | Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin. | 2002 | J. Atheroscler. Thromb. | pmid:12238640 |
| Ando M et al. | Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis. | 2002 | Br. J. Nutr. | pmid:12323083 |
| Baggio SR et al. | Cholesterol oxides, cholesterol, total lipid, and fatty acid composition in turkey meat. | 2002 | J. Agric. Food Chem. | pmid:12358469 |
| Scopesi F et al. | 7-ketocholesterol in human and adapted milk formulas. | 2002 | Clin Nutr | pmid:12381334 |
| Deckert V et al. | The impairment of endothelium-dependent arterial relaxation by 7-ketocholesterol is associated with an early activation of protein kinase C. | 2002 | Br. J. Pharmacol. | pmid:12381679 |
| Csallany AS et al. | Protection of superoxide-induced cholesterol oxidation by antioxidants in protic conditions. | 2002 | Int J Food Sci Nutr | pmid:12396465 |
| Moriel P et al. | Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension. | 2002 | Braz. J. Med. Biol. Res. | pmid:12426629 |
| Jessup W et al. | Oxidized lipoproteins and macrophages. | 2002 | Vascul. Pharmacol. | pmid:12449020 |
| Uemura M et al. | Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation. | 2002 | Eur. J. Pharmacol. | pmid:12450566 |
| Kahn E et al. | Flow cytometry and factor analysis evaluation of confocal image sequences of morphologic and functional changes occurring at the mitochondrial level during 7-ketocholesterol-induced cell death. | 2002 | Anal. Quant. Cytol. Histol. | pmid:12508695 |
| Iuliano L et al. | Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status. | 2003 | Anal. Biochem. | pmid:12531208 |
| Zhang Y et al. | Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1. | 2003 | J. Biol. Chem. | pmid:12533546 |
| McKeague AL et al. | Staurosporine-induced apoptosis and hydrogen peroxide-induced necrosis in two human breast cell lines. | 2003 | Br. J. Cancer | pmid:12556971 |
| Rosenblat M et al. | Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615656 |
| Jacheć W et al. | Lipid peroxidation and vitamin E in human coronary atherosclerotic lesions. | 2003 | Clin. Chim. Acta | pmid:12636930 |
| Zahm JM et al. | Chronology of cellular alterations during 7-ketocholesterol-induced cell death on A7R5 rat smooth muscle cells: analysis by time lapse-video microscopy and conventional fluorescence microscopy. | 2003 | Cytometry A | pmid:12655649 |
| Chang MY et al. | Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12663372 |
| Kawai Y et al. | Covalent binding of oxidized cholesteryl esters to protein: implications for oxidative modification of low density lipoprotein and atherosclerosis. | 2003 | J. Biol. Chem. | pmid:12663661 |
| Bortolomeazzi R et al. | Presence of phytosterol oxides in crude vegetable oils and their fate during refining. | 2003 | J. Agric. Food Chem. | pmid:12670187 |
| Monier S et al. | Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670484 |
| Ong JM et al. | Oxysterol-induced toxicity in R28 and ARPE-19 cells. | 2003 | Neurochem. Res. | pmid:12718442 |
| Akiba S et al. | Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification. | 2003 | J. Lipid Res. | pmid:12777475 |
| Adachi J et al. | Consecutive administration of paraquat to rats induces enhanced cholesterol peroxidation and lung injury. | 2003 | Arch. Toxicol. | pmid:12799775 |
| Adachi J et al. | 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle. | 2003 | Leg Med (Tokyo) | pmid:12935564 |
| Ong WY et al. | Increase in cholesterol and cholesterol oxidation products, and role of cholesterol oxidation products in kainate-induced neuronal injury. | 2003 | Brain Pathol. | pmid:12946016 |
| Petrón MJ et al. | Identification and quantification of cholesterol and cholesterol oxidation products in different types of Iberian hams. | 2003 | J. Agric. Food Chem. | pmid:12952434 |
| ROSENKRANTZ H and GUT M | Hydrogen bonding in 7-ketocholesterol and a new isomorph of 7-ketocholesteryl acetate. | 1954 | Science | pmid:13216220 |
| Hwang PL | Inhibitors of protein and RNA synthesis block the cytotoxic effects of oxygenated sterols. | 1992 | Biochim. Biophys. Acta | pmid:1379472 |
| Kupferberg A et al. | Separation and purification of dolichol and dolichyl phosphate by anion-exchange paper chromatography: application to cultured cells. | 1992 | Anal. Biochem. | pmid:1443591 |
| Akiba S et al. | Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14521937 |
| Girão H et al. | 7-ketocholesterol stimulates differentiation of lens epithelial cells. | 2003 | Mol. Vis. | pmid:14551533 |
| Geng YJ et al. | Cholesterol crystallization and macrophage apoptosis: implication for atherosclerotic plaque instability and rupture. | 2003 | Biochem. Pharmacol. | pmid:14555225 |
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Rusiñol AE et al. | AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis. | 2004 | J. Biol. Chem. | pmid:14559920 |