7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moriel P et al. | Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension. | 2002 | Braz. J. Med. Biol. Res. | pmid:12426629 |
| Dushkin MI et al. | Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages. | 2006 | Bull. Exp. Biol. Med. | pmid:16984105 |
| Soejima S et al. | Hyperthermic sensitivity and cholesterol levels of mammalian cell lines in culture. | 1991 | Cancer Lett. | pmid:1933839 |
| Ramachandran CK et al. | Enhancement in the adhesion of tumor cells to endothelial cells by decreased cholesterol synthesis. | 1986 | Cancer Res. | pmid:3697991 |
| Zabirnyk O et al. | Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. | 2010 | Carcinogenesis | pmid:19942609 |
| Appukuttan A et al. | Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase. | 2013 | Cardiovasc. Res. | pmid:23729662 |
| Seye CI et al. | 7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling. | 2004 | Cardiovasc. Res. | pmid:15364622 |
| Zhang Y et al. | Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. | 2014 | Cardiovasc. Res. | pmid:24445604 |
| Hans CP et al. | Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability. | 2008 | Cardiovasc. Res. | pmid:18245064 |
| Lemaire-Ewing S et al. | Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. | 2005 | Cell Biol. Toxicol. | pmid:16142584 |
| O'Callaghan YC et al. | Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. | 2001 | Cell Biol. Toxicol. | pmid:11499696 |
| Cantwell H and Devery R | The response of the antioxidant defense system in rat hepatocytes challenged with oxysterols is modified by Covi-ox. | 1998 | Cell Biol. Toxicol. | pmid:9879932 |
| Harder T and Sangani D | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. | 2009 | Cell Commun. Signal | pmid:19732448 |
| Miguet C et al. | Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | 2001 | Cell Death Differ. | pmid:11313706 |
| Berthier A et al. | Involvement of a calcium-dependent dephosphorylation of BAD associated with the localization of Trpc-1 within lipid rafts in 7-ketocholesterol-induced THP-1 cell apoptosis. | 2004 | Cell Death Differ. | pmid:15105836 |
| Lim L et al. | Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. | 2012 | Cell Death Differ. | pmid:21818119 |
| Menu P et al. | Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome. | 2011 | Cell Death Dis | pmid:21451572 |
| Hult M et al. | Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism. | 2004 | Cell. Mol. Life Sci. | pmid:15095019 |
| Xu M et al. | Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene. | 2015 | Cell. Physiol. Biochem. | pmid:26315049 |
| Tesoriere L et al. | Oxysterol mixture in hypercholesterolemia-relevant proportion causes oxidative stress-dependent eryptosis. | 2014 | Cell. Physiol. Biochem. | pmid:25228229 |
| Lahoua Z et al. | Oxysterol activation of arachidonic acid release and prostaglandin E2 biosynthesis in NRK 49F cells is partially dependent on protein kinase C activity [corrected]. | 1991 | Cell. Signal. | pmid:1786206 |
| Deiana M et al. | Hydroxytyrosol glucuronides protect renal tubular epithelial cells against H(2)O(2) induced oxidative damage. | 2011 | Chem. Biol. Interact. | pmid:21798251 |
| Debbabi M et al. | Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells. | 2017 | Chem. Phys. Lipids | pmid:28408132 |
| Rosa A et al. | Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation. | 2008 | Chem. Phys. Lipids | pmid:18498764 |
| Ragot K et al. | α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes. | 2011 | Chem. Phys. Lipids | pmid:21575614 |
| Rosa A et al. | Protective role of arzanol against lipid peroxidation in biological systems. | 2011 | Chem. Phys. Lipids | pmid:20932961 |
| Mintzer E et al. | Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes. | 2010 | Chem. Phys. Lipids | pmid:20471966 |
| Rosa-Fernandes L et al. | Outside-in, inside-out: Proteomic analysis of endothelial stress mediated by 7-ketocholesterol. | 2017 | Chem. Phys. Lipids | pmid:28663071 |
| Ghosh S and Khare SK | Biodegradation of 7-Ketocholesterol by Rhodococcus erythropolis MTCC 3951: Process optimization and enzymatic insights. | 2017 | Chem. Phys. Lipids | pmid:28571786 |
| Bezine M et al. | Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. | 2017 | Chem. Phys. Lipids | pmid:28322741 |
| Smondyrev AM and Berkowitz ML | Effects of oxygenated sterol on phospholipid bilayer properties: a molecular dynamics simulation. | 2001 | Chem. Phys. Lipids | pmid:11518570 |
| Coomes E et al. | Methotrexate in atherogenesis and cholesterol metabolism. | 2011 | Cholesterol | pmid:21490773 |
| Sanson M et al. | Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. | 2009 | Circ. Res. | pmid:19106412 |
| Rao X et al. | CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. | 2014 | Circ. Res. | pmid:25186795 |
| Song J et al. | Association of Plasma 7-Ketocholesterol With Cardiovascular Outcomes and Total Mortality in Patients With Coronary Artery Disease. | 2017 | Circ. Res. | pmid:28381400 |
| Wen Y and Leake DS | Low density lipoprotein undergoes oxidation within lysosomes in cells. | 2007 | Circ. Res. | pmid:17446432 |
| Deckert V et al. | Inhibitors of arterial relaxation among components of human oxidized low-density lipoproteins. Cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation. | 1997 | Circulation | pmid:9024163 |
| Myoishi M et al. | Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. | 2007 | Circulation | pmid:17709641 |
| Fülöp T et al. | Immunosupportive therapies in aging. | 2007 | Clin Interv Aging | pmid:18044074 |
| Scopesi F et al. | 7-ketocholesterol in human and adapted milk formulas. | 2002 | Clin Nutr | pmid:12381334 |
| Abo K et al. | Comparative analysis of plasma and erythrocyte 7-ketocholesterol as a marker for oxidative stress in patients with diabetes mellitus. | 2000 | Clin. Biochem. | pmid:11124339 |
| Klinke G et al. | LC-MS/MS based assay and reference intervals in children and adolescents for oxysterols elevated in Niemann-Pick diseases. | 2015 | Clin. Biochem. | pmid:25819840 |
| Matysik S et al. | Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. | 2012 | Clin. Chem. | pmid:22997279 |
| Adachi J et al. | Enhanced lipid peroxidation in tourniquet-release mice. | 2006 | Clin. Chim. Acta | pmid:16624265 |
| Jacheć W et al. | Lipid peroxidation and vitamin E in human coronary atherosclerotic lesions. | 2003 | Clin. Chim. Acta | pmid:12636930 |
| Burnett JR et al. | Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis. | 2001 | Clin. Chim. Acta | pmid:11282095 |
| Tsuzuki D et al. | Analysis of 7-ketocholesterol in low density lipoprotein and fatty acid composition in erythrocyte membranes of patients on maintenance hemodialysis and healthy controls. | 2000 | Clin. Chim. Acta | pmid:10767401 |
| Romanello M et al. | Comprehensive Evaluation of Plasma 7-Ketocholesterol and Cholestan-3β,5α,6β-Triol in an Italian Cohort of Patients Affected by Niemann-Pick Disease due to NPC1 and SMPD1 Mutations. | 2016 | Clin. Chim. Acta | pmid:26790753 |
| Boenzi S et al. | A new simple and rapid LC-ESI-MS/MS method for quantification of plasma oxysterols as dimethylaminobutyrate esters. Its successful use for the diagnosis of Niemann-Pick type C disease. | 2014 | Clin. Chim. Acta | pmid:25038260 |
| Helmschrodt C et al. | Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque. | 2013 | Clin. Chim. Acta | pmid:23827692 |