7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tian L et al. | Red and white wines inhibit cholesterol oxidation induced by free radicals. | 2011 | J. Agric. Food Chem. | pmid:21563753 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Mariutti LR et al. | Lipid and cholesterol oxidation in chicken meat are inhibited by sage but not by garlic. | 2011 | J. Food Sci. | pmid:22417489 |
| Wyrwoll CS et al. | 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. | 2011 | Front Neuroendocrinol | pmid:21144857 |
| Ebrahimi KB and Handa JT | Lipids, lipoproteins, and age-related macular degeneration. | 2011 | J Lipids | pmid:21822496 |
| Magenau A et al. | Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. | 2011 | Traffic | pmid:21883764 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| Palozza P et al. | Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. | 2011 | J. Nutr. Biochem. | pmid:20573495 |
| Flück CE et al. | Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia. | 2011 | PLoS ONE | pmid:21647419 |
| Shui G et al. | Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: applications to a rabbit model for atherosclerosis. | 2011 | J Chromatogr A | pmid:21621788 |
| Li W et al. | Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21621514 |
| Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
| Jang ER and Lee CS | 7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways. | 2011 | Neurochem. Int. | pmid:21035514 |
| Heo GY et al. | Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells. | 2011 | J. Lipid Res. | pmid:21411718 |
| Kahn E et al. | Impact of 7-ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: evaluation via LAURDAN and FAMIS spectral image analysis. | 2011 | Cytometry A | pmid:21381190 |
| Jiang X et al. | A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. | 2011 | J. Lipid Res. | pmid:21518695 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Ragot K et al. | α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes. | 2011 | Chem. Phys. Lipids | pmid:21575614 |
| Marchetti V et al. | Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy. | 2011 | Sci Rep | pmid:22355595 |
| Itabe H et al. | The Dynamics of Oxidized LDL during Atherogenesis. | 2011 | J Lipids | pmid:21660303 |
| VÃlchez C et al. | Marine carotenoids: biological functions and commercial applications. | 2011 | Mar Drugs | pmid:21556162 |
| Charvet C et al. | Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1. | 2011 | J. Biol. Chem. | pmid:21498512 |
| Coomes E et al. | Methotrexate in atherogenesis and cholesterol metabolism. | 2011 | Cholesterol | pmid:21490773 |
| Menu P et al. | Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome. | 2011 | Cell Death Dis | pmid:21451572 |
| Aye IL et al. | Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. | 2011 | Placenta | pmid:21208656 |
| Niki E | Do free radicals play causal role in atherosclerosis? Low density lipoprotein oxidation and vitamin E revisited. | 2011 | J Clin Biochem Nutr | pmid:21297905 |
| Vestergaard MC et al. | The effect of oxycholesterols on thermo-induced membrane dynamics. | 2011 | Biochim. Biophys. Acta | pmid:21600872 |
| Le Lay S et al. | Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux. | 2011 | PLoS ONE | pmid:21858084 |
| Rosa A et al. | Protective role of arzanol against lipid peroxidation in biological systems. | 2011 | Chem. Phys. Lipids | pmid:20932961 |
| Zocche Soprana H et al. | Cellular prion protein (PrP(C)) and superoxide dismutase (SOD) in vascular cells under oxidative stress. | 2011 | Exp. Toxicol. Pathol. | pmid:20060694 |
| Villard PH et al. | CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site. | 2011 | PLoS ONE | pmid:21304969 |
| Deiana M et al. | Hydroxytyrosol glucuronides protect renal tubular epithelial cells against H(2)O(2) induced oxidative damage. | 2011 | Chem. Biol. Interact. | pmid:21798251 |
| Zhou T et al. | The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. | 2011 | Diabetologia | pmid:20978740 |
| Clariana M and GarcÃa-Regueiro JA | Effect of high pressure processing on cholesterol oxidation products in vacuum packaged sliced dry-cured ham. | 2011 | Food Chem. Toxicol. | pmid:21426921 |
| Shinkyo R et al. | Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. | 2011 | J. Biol. Chem. | pmid:21813643 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Xu L et al. | Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. | 2011 | J. Lipid Res. | pmid:21817059 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |
| Kim WK et al. | Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells. | 2010 | J. Bone Miner. Res. | pmid:19839776 |
| Mascia C et al. | Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate. | 2010 | Free Radic. Biol. Med. | pmid:20923702 |
| Dugas B et al. | Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol. | 2010 | Eur J Nutr | pmid:20339855 |
| Deiana M et al. | Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells. | 2010 | Food Chem. Toxicol. | pmid:20691238 |
| Wang Y et al. | Isolation and identification of two steroid compounds from Oviductus Ranae. | 2010 | Nat. Prod. Res. | pmid:20835952 |
| Janoszka B | 7-Ketocholesterol and 7-hydroxycholesterol in pork meat and its gravy thermally treated without additives and in the presence of onion and garlic. | 2010 | Meat Sci. | pmid:20822860 |
| Hilario MC et al. | Feeding goats on scrubby Mexican rangeland and pasteurization: influences on milk and artisan cheese quality. | 2010 | Trop Anim Health Prod | pmid:20229357 |
| Zabirnyk O et al. | Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. | 2010 | Carcinogenesis | pmid:19942609 |
| Klimenko OV et al. | Influence of the lung mechanical ventilation with injurious parameters on 7-ketocholesterol synthesis in Sus Scrofa. | 2010 | BMB Rep | pmid:20423610 |
| Huang Z et al. | 7-ketocholesterol induces cell apoptosis by activation of nuclear factor kappa B in mouse macrophages. | 2010 | Acta Med. Okayama | pmid:20424663 |
| Sharma A et al. | Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice. | 2010 | Libyan J Med | pmid:21483544 |
| Pascual I et al. | Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage. | 2010 | Exp. Eye Res. | pmid:20026324 |