7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nashev LG et al. | Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. | 2007 | PLoS ONE | pmid:17593962 |
| Larsson H et al. | In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress. | 2007 | Free Radic. Biol. Med. | pmid:17664133 |
| Deiana M et al. | Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetate. | 2007 | Food Chem. Toxicol. | pmid:17686562 |
| Rittmann BE and Schloendorn J | Engineering away lysosomal junk: medical bioremediation. | 2007 | Rejuvenation Res | pmid:17708688 |
| Myoishi M et al. | Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. | 2007 | Circulation | pmid:17709641 |
| Cox RH and Spencer EY | The Effect of 7-Ketocholesterol on the Rabbit. | 1949 | Science | pmid:17753811 |
| Terasaka N et al. | High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17846428 |
| Lahoua Z et al. | Oxysterol activation of arachidonic acid release and prostaglandin E2 biosynthesis in NRK 49F cells is partially dependent on protein kinase C activity [corrected]. | 1991 | Cell. Signal. | pmid:1786206 |
| Gerry AB et al. | A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein. | 2008 | Atherosclerosis | pmid:17945239 |
| Farooqui AA et al. | Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans. | 2007 | Brain Res Rev | pmid:17959252 |
| Palozza P et al. | The protective role of carotenoids against 7-keto-cholesterol formation in solution. | 2008 | Mol. Cell. Biochem. | pmid:18008144 |
| Fülöp T et al. | Immunosupportive therapies in aging. | 2007 | Clin Interv Aging | pmid:18044074 |
| Luthra S et al. | 7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro. | 2008 | Microvasc. Res. | pmid:18068200 |
| Endo K et al. | Determination of serum 7-ketocholesterol concentrations and their relationships with coronary multiple risks in diabetes mellitus. | 2008 | Diabetes Res. Clin. Pract. | pmid:18207277 |
| Mizukami M et al. | Proteome profiling of embryo chick retina. | 2008 | Proteome Sci | pmid:18208622 |
| Guo Z et al. | Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. | 2008 | Free Radic. Biol. Med. | pmid:18215741 |
| Lee CY et al. | Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. | 2008 | Free Radic. Biol. Med. | pmid:18226605 |
| Romeo GR and Kazlauskas A | Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. | 2008 | J. Biol. Chem. | pmid:18230613 |
| Hans CP et al. | Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability. | 2008 | Cardiovasc. Res. | pmid:18245064 |
| Bach D et al. | Interaction of 7-ketocholesterol with two major components of the inner leaflet of the plasma membrane: phosphatidylethanolamine and phosphatidylserine. | 2008 | Biochemistry | pmid:18247524 |
| Saitoh E et al. | [Variance of expressions of extracellular matrix components and effects of anti-osteoporotic drugs on Mönckeberg's arteriosclerosis]. | 2008 | Yakugaku Zasshi | pmid:18311057 |
| Mathieu J et al. | Microbial degradation of 7-ketocholesterol. | 2008 | Biodegradation | pmid:18344006 |
| Kim DH and Frangos JA | Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols. | 2008 | Biophys. J. | pmid:18390616 |
| Rosa A et al. | Protective effect of vanilloids against tert-butyl hydroperoxide-induced oxidative stress in vero cells culture. | 2008 | J. Agric. Food Chem. | pmid:18439017 |
| Soustelle L et al. | UV laser mediated cell selective destruction by confocal microscopy. | 2008 | Neural Dev | pmid:18442390 |
| Martinet W et al. | Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells. | 2008 | Br. J. Pharmacol. | pmid:18469840 |
| Vejux A et al. | Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis. | 2009 | J. Nutr. Biochem. | pmid:18495460 |
| Rosa A et al. | Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation. | 2008 | Chem. Phys. Lipids | pmid:18498764 |
| Rentero C et al. | Functional implications of plasma membrane condensation for T cell activation. | 2008 | PLoS ONE | pmid:18509459 |
| Sung SC et al. | 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells. | 2009 | J. Vasc. Res. | pmid:18515973 |
| Deiana M et al. | Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H(2)O(2) induced lipid peroxidation in renal tubular epithelial cells. | 2008 | Food Chem. Toxicol. | pmid:18588937 |
| Saito E et al. | 7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells. | 2008 | J. Atheroscler. Thromb. | pmid:18603819 |
| Freeman-Anderson NE et al. | Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis. | 2008 | J. Lipid Res. | pmid:18614816 |
| Borlak J and Jenke HS | Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation. | 2008 | Mol. Cancer Res. | pmid:18708364 |
| Alkazemi D et al. | Oxysterol as a marker of atherogenic dyslipidemia in adolescence. | 2008 | J. Clin. Endocrinol. Metab. | pmid:18713821 |
| Vejux A et al. | Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis. | 2008 | Braz. J. Med. Biol. Res. | pmid:18719735 |
| Wamil M et al. | 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type. | 2008 | Endocrinology | pmid:18755798 |
| Kratzer A et al. | Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia. | 2009 | J. Lipid Res. | pmid:18812595 |
| Sankaranarayanan S et al. | Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. | 2009 | J. Lipid Res. | pmid:18827283 |
| Terasaka N et al. | ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. | 2008 | J. Clin. Invest. | pmid:18924609 |
| Moreira EF et al. | 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:18936140 |
| Balázs Z et al. | Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1. | 2009 | Mol. Cell. Endocrinol. | pmid:19010388 |
| Noguchi N | Role of oxidative stress in adaptive responses in special reference to atherogenesis. | 2008 | J Clin Biochem Nutr | pmid:19015746 |
| Sanson M et al. | Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. | 2009 | Circ. Res. | pmid:19106412 |
| Kuehnle K et al. | Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. | 2009 | Neurochem. Res. | pmid:19115107 |
| Kell DB | Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. | 2009 | BMC Med Genomics | pmid:19133145 |
| Palozza P et al. | Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. | 2010 | J. Nutr. Biochem. | pmid:19157829 |
| Khokhlov AN et al. | Effects of cholesterol- or 7-ketocholesterol-containing liposomes on colony-forming ability of cultured cells. | 1991 | FEBS Lett. | pmid:1915871 |
| Kim DE et al. | Glycyrrhizin prevents 7-ketocholesterol toxicity against differentiated PC12 cells by suppressing mitochondrial membrane permeability change. | 2009 | Neurochem. Res. | pmid:19224363 |
| Hynynen R et al. | OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. | 2009 | J. Lipid Res. | pmid:19224871 |