7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chien JT et al. | Integral kinetic model for studying quercetin degradation and oxidation as affected by cholesterol during heating. | 2010 | Int J Mol Sci | pmid:21152275 |
| Wyrwoll CS et al. | 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. | 2011 | Front Neuroendocrinol | pmid:21144857 |
| Jang ER and Lee CS | 7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways. | 2011 | Neurochem. Int. | pmid:21035514 |
| Zhou T et al. | The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. | 2011 | Diabetologia | pmid:20978740 |
| Rosa A et al. | Protective role of arzanol against lipid peroxidation in biological systems. | 2011 | Chem. Phys. Lipids | pmid:20932961 |
| Mascia C et al. | Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate. | 2010 | Free Radic. Biol. Med. | pmid:20923702 |
| Seimon TA et al. | Induction of ER stress in macrophages of tuberculosis granulomas. | 2010 | PLoS ONE | pmid:20856677 |
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Wang Y et al. | Isolation and identification of two steroid compounds from Oviductus Ranae. | 2010 | Nat. Prod. Res. | pmid:20835952 |
| Janoszka B | 7-Ketocholesterol and 7-hydroxycholesterol in pork meat and its gravy thermally treated without additives and in the presence of onion and garlic. | 2010 | Meat Sci. | pmid:20822860 |
| Kahn E et al. | Analysis of the capture and influence of nanoparticles on the cytotoxic effects of 7-ketocholesterol on cardiac cells: investigation by flow cytometry and by dynamic and spectral imaging microscopy associated with factor analysis of medical image sequences. | 2009 | Anal. Quant. Cytol. Histol. | pmid:20698354 |
| Deiana M et al. | Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells. | 2010 | Food Chem. Toxicol. | pmid:20691238 |
| Netherland C and Thewke DP | Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20609360 |
| Palozza P et al. | Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. | 2011 | J. Nutr. Biochem. | pmid:20573495 |
| Aye IL et al. | Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. | 2010 | Biochim. Biophys. Acta | pmid:20570635 |
| RodrÃguez IR and Larrayoz IM | Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration. | 2010 | J. Lipid Res. | pmid:20567027 |
| Larrayoz IM et al. | 7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20554621 |
| Owen DM et al. | High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells. | 2010 | Mol. Membr. Biol. | pmid:20540668 |
| Kathir K et al. | Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and nondiabetic subjects. | 2010 | Free Radic. Biol. Med. | pmid:20478379 |
| Mintzer E et al. | Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes. | 2010 | Chem. Phys. Lipids | pmid:20471966 |
| Liao PL et al. | 7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways. | 2010 | Toxicol. Lett. | pmid:20466046 |
| Kahn E et al. | Iron nanoparticles increase 7-ketocholesterol-induced cell death, inflammation, and oxidation on murine cardiac HL1-NB cells. | 2010 | Int J Nanomedicine | pmid:20463934 |
| Jarvie E et al. | Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. | 2010 | Clin. Sci. | pmid:20443782 |
| Huang Z et al. | 7-ketocholesterol induces cell apoptosis by activation of nuclear factor kappa B in mouse macrophages. | 2010 | Acta Med. Okayama | pmid:20424663 |
| Klimenko OV et al. | Influence of the lung mechanical ventilation with injurious parameters on 7-ketocholesterol synthesis in Sus Scrofa. | 2010 | BMB Rep | pmid:20423610 |
| Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
| Suzuki K et al. | Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22. | 2010 | J. Periodont. Res. | pmid:20412422 |
| Shentu TP et al. | oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20410437 |
| Li D et al. | Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20395595 |
| Kim JS et al. | Cytoprotective effect of polysaccharide isolated from different mushrooms against 7-ketocholesterol induced damage in mouse liver cell line (BNL CL. 2). | 2007 | Nutr Res Pract | pmid:20368935 |
| Dugas B et al. | Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol. | 2010 | Eur J Nutr | pmid:20339855 |
| Jialal I et al. | Varying susceptibility of different low density lipoproteins to oxidative modification. | 1991 May-Jun | Arterioscler. Thromb. | pmid:2029490 |
| Hilario MC et al. | Feeding goats on scrubby Mexican rangeland and pasteurization: influences on milk and artisan cheese quality. | 2010 | Trop Anim Health Prod | pmid:20229357 |
| Ingueneau C et al. | TRPC1 is regulated by caveolin-1 and is involved in oxidized LDL-induced apoptosis of vascular smooth muscle cells. | 2009 | J. Cell. Mol. Med. | pmid:20187291 |
| Ong WY et al. | Changes in brain cholesterol metabolome after excitotoxicity. | 2010 | Mol. Neurobiol. | pmid:20140539 |
| Zocche Soprana H et al. | Cellular prion protein (PrP(C)) and superoxide dismutase (SOD) in vascular cells under oxidative stress. | 2011 | Exp. Toxicol. Pathol. | pmid:20060694 |
| Schloendorn J et al. | Medical bioremediation: a concept moving toward reality. | 2009 | Rejuvenation Res | pmid:20041735 |
| Pascual I et al. | Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage. | 2010 | Exp. Eye Res. | pmid:20026324 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Seet RC et al. | Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. | 2010 | Free Radic. Biol. Med. | pmid:19969070 |
| Kim YJ and Lee CS | Tyrosine kinase inhibitor AG126 reduces 7-ketocholesterol-induced cell death by suppressing mitochondria-mediated apoptotic process. | 2010 | Neurochem. Res. | pmid:19957203 |
| Zabirnyk O et al. | Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. | 2010 | Carcinogenesis | pmid:19942609 |
| Anticoli S et al. | 7-ketocholesterol and 5,6-secosterol modulate differently the stress-activated mitogen-activated protein kinases (MAPKs) in liver cells. | 2010 | J. Cell. Physiol. | pmid:19937729 |
| Mathieu JM et al. | 7-ketocholesterol catabolism by Rhodococcus jostii RHA1. | 2010 | Appl. Environ. Microbiol. | pmid:19880645 |
| Wielkoszyński T et al. | Concentration of anti-7-ketocholesterol antibodies in patient sera after heart transplantation. | 2009 | Transplant. Proc. | pmid:19857711 |
| Kim WK et al. | Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells. | 2010 | J. Bone Miner. Res. | pmid:19839776 |
| Gramajo AL et al. | Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19834037 |
| Huang ZY et al. | [The apoptosis of mouse macrophage J774A.1 induced by oxysterol depend on NF-kappaB activation]. | 2009 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:19811731 |
| Katsogiannou M et al. | Caveolae contribute to the apoptosis resistance induced by the alpha(1A)-adrenoceptor in androgen-independent prostate cancer cells. | 2009 | PLoS ONE | pmid:19763272 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |