7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Freeman NE et al. | Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages. | 2005 | J. Lipid Res. | pmid:15995174 |
| Sankaranarayanan S et al. | Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. | 2009 | J. Lipid Res. | pmid:18827283 |
| Vine DF et al. | Dietary oxysterols are incorporated in plasma triglyceride-rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits. | 1998 | J. Lipid Res. | pmid:9788246 |
| Hayden JM et al. | Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. | 2002 | J. Lipid Res. | pmid:11792719 |
| Lin N et al. | Determination of 7-ketocholesterol in plasma by LC-MS for rapid diagnosis of acid SMase-deficient Niemann-Pick disease. | 2014 | J. Lipid Res. | pmid:24190732 |
| Liu Q et al. | Omega-carboxyl variants of 7-ketocholesteryl esters are ligands for beta(2)-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages. | 2002 | J. Lipid Res. | pmid:12235181 |
| Maor I and Aviram M | Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester. | 1994 | J. Lipid Res. | pmid:8071603 |
| Patel RP et al. | Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. | 1996 | J. Lipid Res. | pmid:8978488 |
| RodrÃguez IR and Larrayoz IM | Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration. | 2010 | J. Lipid Res. | pmid:20567027 |
| Brown AJ et al. | Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages. | 1996 | J. Lipid Res. | pmid:9026530 |
| Akiba S et al. | Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification. | 2003 | J. Lipid Res. | pmid:12777475 |
| Shentu TP et al. | The role of oxysterols in control of endothelial stiffness. | 2012 | J. Lipid Res. | pmid:22496390 |
| Freeman-Anderson NE et al. | Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis. | 2008 | J. Lipid Res. | pmid:18614816 |
| Pajares S et al. | Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency. | 2015 | J. Lipid Res. | pmid:26239048 |
| Davis S et al. | α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein. | 2015 | J. Lipid Res. | pmid:26026069 |
| Tempel W et al. | Structural characterization of human cholesterol 7α-hydroxylase. | 2014 | J. Lipid Res. | pmid:24927729 |
| Kratzer A et al. | Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia. | 2009 | J. Lipid Res. | pmid:18812595 |
| McCourt MP et al. | X-ray crystal structure of cytotoxic oxidized cholesterols: 7-ketocholesterol and 25-hydroxycholesterol. | 1997 | J. Lipid Res. | pmid:9186918 |
| Wnętrzak A et al. | Oxysterols Versus Cholesterol in Model Neuronal Membrane. I. The Case of 7-Ketocholesterol. The Langmuir Monolayer Study. | 2017 | J. Membr. Biol. | pmid:28861595 |
| Rho MC et al. | 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death. | 2005 | J. Mol. Cell. Cardiol. | pmid:16198370 |
| Loke SY et al. | Comprehensive gene expression analyses of the rat prefrontal cortex after oxysterol treatment. | 2013 | J. Neurochem. | pmid:23294445 |
| He X et al. | Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. | 2006 | J. Neuropathol. Exp. Neurol. | pmid:16825952 |
| Moinard C et al. | Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats. | 2015 | J. Nutr. | pmid:26019250 |
| Vejux A et al. | Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis. | 2009 | J. Nutr. Biochem. | pmid:18495460 |
| Palozza P et al. | Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. | 2011 | J. Nutr. Biochem. | pmid:20573495 |
| Palozza P et al. | Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. | 2010 | J. Nutr. Biochem. | pmid:19157829 |
| Lizard G et al. | Induction of similar features of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol. | 1997 | J. Pathol. | pmid:9422990 |
| Suzuki K et al. | Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22. | 2010 | J. Periodont. Res. | pmid:20412422 |
| Smith LL et al. | Sterol metabolism--XLVII. Oxidized cholesterol esters in human tissues. | 1981 | J. Steroid Biochem. | pmid:7300357 |
| Leoni V et al. | Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27020660 |
| Zarrouk A et al. | Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26921765 |
| Gregorio-King CC et al. | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15120425 |
| Silva SF et al. | Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27133385 |
| Odermatt A and Klusonova P | 11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25151952 |
| Nury T et al. | 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27041118 |
| Zong Y et al. | Toxicity of 7-ketocholesterol on lethality, growth, reproduction, and germline apoptosis in the nematode Caenorhabditis elegans. | 2014 | J. Toxicol. Environ. Health Part A | pmid:24786678 |
| Sung SC et al. | 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells. | 2009 | J. Vasc. Res. | pmid:18515973 |
| Scopesi F et al. | Cholesterol oxidation in intravenous lipid emulsions: safety of preparations before and after experimental hyperoxia. | 2004 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:15449575 |
| Nakagawa K et al. | Protective effect of daidzein against acute ethanol-induced lipid peroxidation in rat jejunum. | 2006 | Kobe J Med Sci | pmid:17006054 |
| Telesford DM et al. | Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers. | 2015 | Langmuir | pmid:26322794 |
| Adachi J et al. | 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle. | 2003 | Leg Med (Tokyo) | pmid:12935564 |
| Sharma A et al. | Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice. | 2010 | Libyan J Med | pmid:21483544 |
| Yoda T et al. | Thermo-induced vesicular dynamics of membranes containing cholesterol derivatives. | 2012 | Lipids | pmid:22752691 |
| Parish EJ et al. | A facile synthesis and carbon-13 nuclear magnetic resonance spectral properties of 7-ketocholesteryl benzoate. | 1987 | Lipids | pmid:3431349 |
| Lyons MA and Brown AJ | Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells. | 2001 | Lipids | pmid:11521968 |
| Krut LH et al. | Microscale preparation of natural and labeled oxysterols. | 1996 | Lipids | pmid:8727646 |
| Saldanha T and Bragagnolo N | Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi). | 2007 | Lipids | pmid:17492472 |
| Rutherford LD and Gieseg SP | 7-ketocholesterol is not cytotoxic to U937 cells when incorporated into acetylated low density lipoprotein. | 2012 | Lipids | pmid:22124807 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |