7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhan X et al. | [Blood 7-ketocholesterol level, clinical features and gene mutation analysis of 18 children with Niemann-Pick disease type C]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:27256227 |
| Lee WH et al. | 7-ketocholesterol induces endoplasmic reticulum stress in HT-29 cells. | 2009 Mar-Apr | Z. Naturforsch., C, J. Biosci. | pmid:19526729 |
| Saitoh E et al. | [Variance of expressions of extracellular matrix components and effects of anti-osteoporotic drugs on Mönckeberg's arteriosclerosis]. | 2008 | Yakugaku Zasshi | pmid:18311057 |
| Huang ZY et al. | [The apoptosis of mouse macrophage J774A.1 induced by oxysterol depend on NF-kappaB activation]. | 2009 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:19811731 |
| Corradini SG et al. | Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control. | 2012 | World J. Gastroenterol. | pmid:22408352 |
| Jessup W et al. | Oxidized lipoproteins and macrophages. | 2002 | Vascul. Pharmacol. | pmid:12449020 |
| Hilario MC et al. | Feeding goats on scrubby Mexican rangeland and pasteurization: influences on milk and artisan cheese quality. | 2010 | Trop Anim Health Prod | pmid:20229357 |
| Wielkoszyński T et al. | Concentration of anti-7-ketocholesterol antibodies in patient sera after heart transplantation. | 2009 | Transplant. Proc. | pmid:19857711 |
| Magenau A et al. | Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. | 2011 | Traffic | pmid:21883764 |
| Rosa A et al. | Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues. | 2005 | Toxicol. Lett. | pmid:15795088 |