7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Adiguzel Z et al. | Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols. | 2014 | Mol. Biol. Rep. | pmid:25266234 |
| Son Y et al. | 7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25576871 |
| Lee DH et al. | Rotundarpene attenuates cholesterol oxidation product-induced apoptosis by suppressing the mitochondrial pathway and the caspase-8- and bid-dependent pathways. | 2015 | Eur. J. Pharmacol. | pmid:25592323 |
| Lee JW et al. | Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL. | 2015 | Biochim. Biophys. Acta | pmid:25617738 |
| Rosales C et al. | CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-γ. | 2015 | Atherosclerosis | pmid:25618030 |
| Shi G et al. | Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:25678688 |
| Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
| Luchetti F et al. | 7-Ketocholesterol and 5,6-secosterol induce human endothelial cell dysfunction by differential mechanisms. | 2015 | Steroids | pmid:25697053 |
| Guina T et al. | The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics. | 2015 | Food Funct | pmid:25736858 |
| Chen Y et al. | THP1 macrophages oxidized cholesterol, generating 7-derivative oxysterols specifically released by HDL. | 2015 | Steroids | pmid:25742736 |
| Karilainen T et al. | Oxidation of cholesterol does not alter significantly its uptake into high-density lipoprotein particles. | 2015 | J Phys Chem B | pmid:25768721 |
| Indaram M et al. | 7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration. | 2015 | Sci Rep | pmid:25775051 |
| Klinke G et al. | LC-MS/MS based assay and reference intervals in children and adolescents for oxysterols elevated in Niemann-Pick diseases. | 2015 | Clin. Biochem. | pmid:25819840 |
| Lee DH et al. | Quercetin-3-O-(2″-galloyl)-α-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-κB-mediated cell death process in differentiated PC12 cells. | 2015 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:25845326 |
| Moinard C et al. | Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats. | 2015 | J. Nutr. | pmid:26019250 |
| Davis S et al. | α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein. | 2015 | J. Lipid Res. | pmid:26026069 |
| Laparra JM et al. | 7keto-stigmasterol and 7keto-cholesterol induce differential proteome changes to intestinal epitelial (Caco-2) cells. | 2015 | Food Chem. Toxicol. | pmid:26140950 |
| Pajares S et al. | Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency. | 2015 | J. Lipid Res. | pmid:26239048 |
| Xu M et al. | Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene. | 2015 | Cell. Physiol. Biochem. | pmid:26315049 |
| Telesford DM et al. | Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers. | 2015 | Langmuir | pmid:26322794 |
| Sudo R et al. | 7-Ketocholesterol-induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress. | 2015 | Genes Cells | pmid:26419830 |
| Rasmiena AA et al. | High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein. | 2016 | Biochim. Biophys. Acta | pmid:26569052 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Gajewski A et al. | Helicobacter pylori antigens, acetylsalicylic acid, LDL and 7-ketocholesterol - their potential role in destabilizing the gastric epithelial cell barrier. An in vitro model of Kato III cells. | 2016 | Acta Biochim. Pol. | pmid:26619253 |
| Alba G et al. | 7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils. | 2016 | Eur J Nutr | pmid:26715521 |
| Boenzi S et al. | Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism. | 2016 | J. Lipid Res. | pmid:26733147 |
| Romanello M et al. | Comprehensive Evaluation of Plasma 7-Ketocholesterol and Cholestan-3β,5α,6β-Triol in an Italian Cohort of Patients Affected by Niemann-Pick Disease due to NPC1 and SMPD1 Mutations. | 2016 | Clin. Chim. Acta | pmid:26790753 |
| Zarrouk A et al. | Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26921765 |
| Tran J et al. | Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells. | 2016 | PLoS ONE | pmid:26977592 |
| Ghosh S and Khare SK | Biodegradation of cytotoxic 7-Ketocholesterol by Pseudomonas aeruginosa PseA. | 2016 | Bioresour. Technol. | pmid:27020128 |
| Leoni V et al. | Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27020660 |
| Nury T et al. | 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27041118 |
| Silva SF et al. | Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27133385 |
| Zhan X et al. | [Blood 7-ketocholesterol level, clinical features and gene mutation analysis of 18 children with Niemann-Pick disease type C]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:27256227 |
| Sanda GM et al. | Oxidized LDL-Exposed Human Macrophages Display Increased MMP-9 Expression and Secretion Mediated by Endoplasmic Reticulum Stress. | 2017 | J. Cell. Biochem. | pmid:27341688 |
| Rosa Fernandes L et al. | 7-Ketocholesterol overcomes drug resistance in chronic myeloid leukemia cell lines beyond MDR1 mechanism. | 2017 | J Proteomics | pmid:27343758 |
| Pang C et al. | Biotransformation of cholesterol and 16,17-alpha epoxypregnenolone by novel Cladosporium sp. strain IS547. | 2017 | J. Basic Microbiol. | pmid:27690325 |
| Chang MC et al. | 7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells. | 2016 | Oncotarget | pmid:27740938 |
| Debbabi M et al. | Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells. | 2016 | Int J Mol Sci | pmid:27897980 |
| Musman J et al. | Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. | 2016 | Free Radic. Biol. Med. | pmid:27989751 |
| Bezine M et al. | Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. | 2017 | Chem. Phys. Lipids | pmid:28322741 |
| Cho HR et al. | 7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor. | 2017 | PLoS ONE | pmid:28323848 |
| Ward LJ et al. | Exposure to atheroma-relevant 7-oxysterols causes proteomic alterations in cell death, cellular longevity, and lipid metabolism in THP-1 macrophages. | 2017 | PLoS ONE | pmid:28350877 |
| Song J et al. | Association of Plasma 7-Ketocholesterol With Cardiovascular Outcomes and Total Mortality in Patients With Coronary Artery Disease. | 2017 | Circ. Res. | pmid:28381400 |
| Debbabi M et al. | Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells. | 2017 | Chem. Phys. Lipids | pmid:28408132 |
| Wang M et al. | Plasma 7-ketocholesterol levels and the risk of incident cardiovascular events. | 2017 | Heart | pmid:28490621 |
| Ghosh S and Khare SK | Biodegradation of 7-Ketocholesterol by Rhodococcus erythropolis MTCC 3951: Process optimization and enzymatic insights. | 2017 | Chem. Phys. Lipids | pmid:28571786 |
| Wang Y et al. | Mitochondrial Oxidative Stress Promotes Atherosclerosis and Neutrophil Extracellular Traps in Aged Mice. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28596373 |
| Koka S et al. | Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia. | 2017 | Redox Biol | pmid:28633109 |
| Rosa-Fernandes L et al. | Outside-in, inside-out: Proteomic analysis of endothelial stress mediated by 7-ketocholesterol. | 2017 | Chem. Phys. Lipids | pmid:28663071 |