7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nagayama D et al. | Effects of serotonin on expression of the LDL receptor family member LR11 and 7-ketocholesterol-induced apoptosis in human vascular smooth muscle cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24650663 |
| Nury T et al. | Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress, apoptosis and autophagy, on 7-ketocholesterol-treated 158N murine oligodendrocytes: impairment by α-tocopherol. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24299956 |
| Chalubinski M et al. | The effect of oxidized cholesterol on barrier functions and IL-10 mRNA expression in human intestinal epithelium co-cultured with dendritic cells in the transwell system. | 2014 | Food Chem. Toxicol. | pmid:24727230 |
| Zhang H et al. | Diagnosis of Niemann-Pick disease type C with 7-ketocholesterol screening followed by NPC1/NPC2 gene mutation confirmation in Chinese patients. | 2014 | Orphanet J Rare Dis | pmid:24915861 |
| Huang JD et al. | 7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo. | 2014 | PLoS ONE | pmid:25036103 |
| Buttari B et al. | Resveratrol counteracts inflammation in human M1 and M2 macrophages upon challenge with 7-oxo-cholesterol: potential therapeutic implications in atherosclerosis. | 2014 | Oxid Med Cell Longev | pmid:24895526 |
| Adiguzel Z et al. | Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols. | 2014 | Mol. Biol. Rep. | pmid:25266234 |
| Rodriguez IR et al. | 7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusen. | 2014 | Exp. Eye Res. | pmid:25261634 |
| Tesoriere L et al. | Oxysterol mixture in hypercholesterolemia-relevant proportion causes oxidative stress-dependent eryptosis. | 2014 | Cell. Physiol. Biochem. | pmid:25228229 |
| Rao X et al. | CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. | 2014 | Circ. Res. | pmid:25186795 |
| Tempel W et al. | Structural characterization of human cholesterol 7α-hydroxylase. | 2014 | J. Lipid Res. | pmid:24927729 |
| Phan HT et al. | Localization of amyloid beta (Aβ1-42) protofibrils in membrane lateral compartments: effect of cholesterol and 7-Ketocholesterol. | 2014 | FEBS Lett. | pmid:25131929 |
| Boenzi S et al. | A new simple and rapid LC-ESI-MS/MS method for quantification of plasma oxysterols as dimethylaminobutyrate esters. Its successful use for the diagnosis of Niemann-Pick type C disease. | 2014 | Clin. Chim. Acta | pmid:25038260 |
| Guina T et al. | The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics. | 2015 | Food Funct | pmid:25736858 |
| Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
| Telesford DM et al. | Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers. | 2015 | Langmuir | pmid:26322794 |
| Luchetti F et al. | 7-Ketocholesterol and 5,6-secosterol induce human endothelial cell dysfunction by differential mechanisms. | 2015 | Steroids | pmid:25697053 |
| Karilainen T et al. | Oxidation of cholesterol does not alter significantly its uptake into high-density lipoprotein particles. | 2015 | J Phys Chem B | pmid:25768721 |
| Lee DH et al. | Quercetin-3-O-(2″-galloyl)-α-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-κB-mediated cell death process in differentiated PC12 cells. | 2015 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:25845326 |
| Chen Y et al. | THP1 macrophages oxidized cholesterol, generating 7-derivative oxysterols specifically released by HDL. | 2015 | Steroids | pmid:25742736 |
| Rosales C et al. | CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-γ. | 2015 | Atherosclerosis | pmid:25618030 |
| Sudo R et al. | 7-Ketocholesterol-induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress. | 2015 | Genes Cells | pmid:26419830 |
| Xu M et al. | Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene. | 2015 | Cell. Physiol. Biochem. | pmid:26315049 |
| Pajares S et al. | Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency. | 2015 | J. Lipid Res. | pmid:26239048 |
| Davis S et al. | α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein. | 2015 | J. Lipid Res. | pmid:26026069 |
| Moinard C et al. | Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats. | 2015 | J. Nutr. | pmid:26019250 |
| Indaram M et al. | 7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration. | 2015 | Sci Rep | pmid:25775051 |
| Shi G et al. | Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:25678688 |
| Lee JW et al. | Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL. | 2015 | Biochim. Biophys. Acta | pmid:25617738 |
| Laparra JM et al. | 7keto-stigmasterol and 7keto-cholesterol induce differential proteome changes to intestinal epitelial (Caco-2) cells. | 2015 | Food Chem. Toxicol. | pmid:26140950 |
| Klinke G et al. | LC-MS/MS based assay and reference intervals in children and adolescents for oxysterols elevated in Niemann-Pick diseases. | 2015 | Clin. Biochem. | pmid:25819840 |
| Son Y et al. | 7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25576871 |
| Odermatt A and Klusonova P | 11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25151952 |
| Lee DH et al. | Rotundarpene attenuates cholesterol oxidation product-induced apoptosis by suppressing the mitochondrial pathway and the caspase-8- and bid-dependent pathways. | 2015 | Eur. J. Pharmacol. | pmid:25592323 |
| Musman J et al. | Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. | 2016 | Free Radic. Biol. Med. | pmid:27989751 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Rasmiena AA et al. | High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein. | 2016 | Biochim. Biophys. Acta | pmid:26569052 |
| Alba G et al. | 7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils. | 2016 | Eur J Nutr | pmid:26715521 |
| Tran J et al. | Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells. | 2016 | PLoS ONE | pmid:26977592 |
| Boenzi S et al. | Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism. | 2016 | J. Lipid Res. | pmid:26733147 |
| Gajewski A et al. | Helicobacter pylori antigens, acetylsalicylic acid, LDL and 7-ketocholesterol - their potential role in destabilizing the gastric epithelial cell barrier. An in vitro model of Kato III cells. | 2016 | Acta Biochim. Pol. | pmid:26619253 |
| Chang MC et al. | 7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells. | 2016 | Oncotarget | pmid:27740938 |
| Zhan X et al. | [Blood 7-ketocholesterol level, clinical features and gene mutation analysis of 18 children with Niemann-Pick disease type C]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:27256227 |
| Debbabi M et al. | Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells. | 2016 | Int J Mol Sci | pmid:27897980 |
| Ghosh S and Khare SK | Biodegradation of cytotoxic 7-Ketocholesterol by Pseudomonas aeruginosa PseA. | 2016 | Bioresour. Technol. | pmid:27020128 |
| Romanello M et al. | Comprehensive Evaluation of Plasma 7-Ketocholesterol and Cholestan-3β,5α,6β-Triol in an Italian Cohort of Patients Affected by Niemann-Pick Disease due to NPC1 and SMPD1 Mutations. | 2016 | Clin. Chim. Acta | pmid:26790753 |
| Pang C et al. | Biotransformation of cholesterol and 16,17-alpha epoxypregnenolone by novel Cladosporium sp. strain IS547. | 2017 | J. Basic Microbiol. | pmid:27690325 |
| Rosa Fernandes L et al. | 7-Ketocholesterol overcomes drug resistance in chronic myeloid leukemia cell lines beyond MDR1 mechanism. | 2017 | J Proteomics | pmid:27343758 |
| Song J et al. | Association of Plasma 7-Ketocholesterol With Cardiovascular Outcomes and Total Mortality in Patients With Coronary Artery Disease. | 2017 | Circ. Res. | pmid:28381400 |
| Bezine M et al. | Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. | 2017 | Chem. Phys. Lipids | pmid:28322741 |