7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chew PY et al. | Does lycopene offer human LDL any protection against myeloperoxidase activity? | 2012 | Mol. Cell. Biochem. | pmid:21987235 |
| Palozza P et al. | The protective role of carotenoids against 7-keto-cholesterol formation in solution. | 2008 | Mol. Cell. Biochem. | pmid:18008144 |
| Borlak J and Jenke HS | Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation. | 2008 | Mol. Cancer Res. | pmid:18708364 |
| Adiguzel Z et al. | Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols. | 2014 | Mol. Biol. Rep. | pmid:25266234 |
| Leonarduzzi G et al. | Trojan horse-like behavior of a biologically representative mixture of oxysterols. | 2004 Feb-Apr | Mol. Aspects Med. | pmid:15051324 |
| Brown AJ and Jessup W | Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis. | 2009 | Mol. Aspects Med. | pmid:19248801 |
| Luthra S et al. | 7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro. | 2008 | Microvasc. Res. | pmid:18068200 |
| Yamagata K et al. | Epigallocatechin 3-gallate inhibits 7-ketocholesterol-induced monocyte-endothelial cell adhesion. | 2013 | Microvasc. Res. | pmid:23567873 |
| Mathieu JM et al. | Medical bioremediation of age-related diseases. | 2009 | Microb. Cell Fact. | pmid:19358742 |
| Fujita T et al. | Chronic ethanol feeding increases 7-hydroperoxycholesterol and oxysterols in rat skeletal muscle. | 2002 | Metab. Clin. Exp. | pmid:12037727 |
| Adachi J et al. | Skeletal muscle and liver oxysterols during fasting and alcohol exposure. | 2006 | Metab. Clin. Exp. | pmid:16324930 |
| Inouye M et al. | Glycated hemoglobin and lipid peroxidation in erythrocytes of diabetic patients. | 1999 | Metab. Clin. Exp. | pmid:10024083 |
| Sasaki H et al. | Vascular smooth muscle cell apoptosis induced by 7-ketocholesterol was mediated via Ca2+ and inhibited by the calcium channel blocker nifedipine. | 2007 | Metab. Clin. Exp. | pmid:17292724 |
| Gui T et al. | Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery. | 2012 | Mediators Inflamm. | pmid:22577254 |
| Tomasik A et al. | Impact of baseline level of 7-ketocholesterol on the rate of coronary reintervention in coronary artery disease patients--results of an observational study with questionnaire-based follow up. | 2000 Jul-Aug | Med. Sci. Monit. | pmid:11208404 |
| Janoszka B | 7-Ketocholesterol and 7-hydroxycholesterol in pork meat and its gravy thermally treated without additives and in the presence of onion and garlic. | 2010 | Meat Sci. | pmid:20822860 |
| Ferioli F et al. | Evaluation of cholesterol and lipid oxidation in raw and cooked minced beef stored under oxygen-enriched atmosphere. | 2008 | Meat Sci. | pmid:22063582 |
| Nam KC et al. | Cholesterol oxidation products in irradiated raw meat with different packaging and storage time. | 2001 | Meat Sci. | pmid:22062435 |
| Ahn DU et al. | Effect of irradiation and packaging conditions after cooking on the formation of cholesterol and lipid oxidation products in meats during storage. | 2001 | Meat Sci. | pmid:22061714 |
| VÃlchez C et al. | Marine carotenoids: biological functions and commercial applications. | 2011 | Mar Drugs | pmid:21556162 |
| Corradini SG et al. | High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. | 2005 | Liver Transpl. | pmid:16258953 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Yoda T et al. | Thermo-induced vesicular dynamics of membranes containing cholesterol derivatives. | 2012 | Lipids | pmid:22752691 |
| Parish EJ et al. | A facile synthesis and carbon-13 nuclear magnetic resonance spectral properties of 7-ketocholesteryl benzoate. | 1987 | Lipids | pmid:3431349 |
| Lyons MA and Brown AJ | Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells. | 2001 | Lipids | pmid:11521968 |
| Krut LH et al. | Microscale preparation of natural and labeled oxysterols. | 1996 | Lipids | pmid:8727646 |
| Saldanha T and Bragagnolo N | Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi). | 2007 | Lipids | pmid:17492472 |
| Rutherford LD and Gieseg SP | 7-ketocholesterol is not cytotoxic to U937 cells when incorporated into acetylated low density lipoprotein. | 2012 | Lipids | pmid:22124807 |
| Sharma A et al. | Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice. | 2010 | Libyan J Med | pmid:21483544 |
| Adachi J et al. | 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle. | 2003 | Leg Med (Tokyo) | pmid:12935564 |
| Telesford DM et al. | Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers. | 2015 | Langmuir | pmid:26322794 |
| Nakagawa K et al. | Protective effect of daidzein against acute ethanol-induced lipid peroxidation in rat jejunum. | 2006 | Kobe J Med Sci | pmid:17006054 |
| Scopesi F et al. | Cholesterol oxidation in intravenous lipid emulsions: safety of preparations before and after experimental hyperoxia. | 2004 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:15449575 |
| Sung SC et al. | 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells. | 2009 | J. Vasc. Res. | pmid:18515973 |
| Zong Y et al. | Toxicity of 7-ketocholesterol on lethality, growth, reproduction, and germline apoptosis in the nematode Caenorhabditis elegans. | 2014 | J. Toxicol. Environ. Health Part A | pmid:24786678 |
| Leoni V et al. | Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27020660 |
| Zarrouk A et al. | Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26921765 |
| Gregorio-King CC et al. | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15120425 |
| Silva SF et al. | Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27133385 |
| Odermatt A and Klusonova P | 11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25151952 |
| Nury T et al. | 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27041118 |
| Smith LL et al. | Sterol metabolism--XLVII. Oxidized cholesterol esters in human tissues. | 1981 | J. Steroid Biochem. | pmid:7300357 |
| Suzuki K et al. | Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22. | 2010 | J. Periodont. Res. | pmid:20412422 |
| Lizard G et al. | Induction of similar features of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol. | 1997 | J. Pathol. | pmid:9422990 |
| Vejux A et al. | Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis. | 2009 | J. Nutr. Biochem. | pmid:18495460 |
| Palozza P et al. | Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. | 2011 | J. Nutr. Biochem. | pmid:20573495 |
| Palozza P et al. | Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. | 2010 | J. Nutr. Biochem. | pmid:19157829 |
| Moinard C et al. | Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats. | 2015 | J. Nutr. | pmid:26019250 |
| He X et al. | Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. | 2006 | J. Neuropathol. Exp. Neurol. | pmid:16825952 |