7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Loke SY et al. | Comprehensive gene expression analyses of the rat prefrontal cortex after oxysterol treatment. | 2013 | J. Neurochem. | pmid:23294445 |
| Rho MC et al. | 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death. | 2005 | J. Mol. Cell. Cardiol. | pmid:16198370 |
| Wnętrzak A et al. | Oxysterols Versus Cholesterol in Model Neuronal Membrane. I. The Case of 7-Ketocholesterol. The Langmuir Monolayer Study. | 2017 | J. Membr. Biol. | pmid:28861595 |
| Freeman NE et al. | Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages. | 2005 | J. Lipid Res. | pmid:15995174 |
| Staprans I et al. | Ezetimibe inhibits the incorporation of dietary oxidized cholesterol into lipoproteins. | 2006 | J. Lipid Res. | pmid:16894239 |
| Sankaranarayanan S et al. | Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. | 2009 | J. Lipid Res. | pmid:18827283 |
| Vine DF et al. | Dietary oxysterols are incorporated in plasma triglyceride-rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits. | 1998 | J. Lipid Res. | pmid:9788246 |
| Norlin M et al. | 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). | 2000 | J. Lipid Res. | pmid:11013305 |
| Hakamata H et al. | Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein. | 1998 | J. Lipid Res. | pmid:9548582 |
| Gelissen IC et al. | Oxysterol efflux from macrophage foam cells: the essential role of acceptor phospholipid. | 1999 | J. Lipid Res. | pmid:10484610 |
| Hayden JM et al. | Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. | 2002 | J. Lipid Res. | pmid:11792719 |
| Lin N et al. | Determination of 7-ketocholesterol in plasma by LC-MS for rapid diagnosis of acid SMase-deficient Niemann-Pick disease. | 2014 | J. Lipid Res. | pmid:24190732 |
| Fuda H et al. | Oxysterols are substrates for cholesterol sulfotransferase. | 2007 | J. Lipid Res. | pmid:17347498 |
| Brown AJ et al. | Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes. | 2000 | J. Lipid Res. | pmid:10681406 |
| Hynynen R et al. | OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. | 2009 | J. Lipid Res. | pmid:19224871 |
| Liu Q et al. | Omega-carboxyl variants of 7-ketocholesteryl esters are ligands for beta(2)-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages. | 2002 | J. Lipid Res. | pmid:12235181 |
| Axelson M et al. | Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. | 1995 | J. Lipid Res. | pmid:7751816 |
| Maor I and Aviram M | Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester. | 1994 | J. Lipid Res. | pmid:8071603 |
| Patel RP et al. | Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. | 1996 | J. Lipid Res. | pmid:8978488 |
| RodrÃguez IR and Larrayoz IM | Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration. | 2010 | J. Lipid Res. | pmid:20567027 |
| Heo GY et al. | Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells. | 2011 | J. Lipid Res. | pmid:21411718 |
| Brown AJ et al. | Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages. | 1996 | J. Lipid Res. | pmid:9026530 |
| Akiba S et al. | Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification. | 2003 | J. Lipid Res. | pmid:12777475 |
| Jiang X et al. | A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. | 2011 | J. Lipid Res. | pmid:21518695 |
| Shentu TP et al. | The role of oxysterols in control of endothelial stiffness. | 2012 | J. Lipid Res. | pmid:22496390 |
| Freeman-Anderson NE et al. | Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis. | 2008 | J. Lipid Res. | pmid:18614816 |
| Boenzi S et al. | Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism. | 2016 | J. Lipid Res. | pmid:26733147 |
| Pajares S et al. | Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency. | 2015 | J. Lipid Res. | pmid:26239048 |
| Davis S et al. | α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein. | 2015 | J. Lipid Res. | pmid:26026069 |
| Leoni V et al. | Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis. | 2005 | J. Lipid Res. | pmid:15576852 |
| Tempel W et al. | Structural characterization of human cholesterol 7α-hydroxylase. | 2014 | J. Lipid Res. | pmid:24927729 |
| Kratzer A et al. | Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia. | 2009 | J. Lipid Res. | pmid:18812595 |
| Björkhem I et al. | On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO. | 2014 | J. Lipid Res. | pmid:24771866 |
| Xu L et al. | Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. | 2011 | J. Lipid Res. | pmid:21817059 |
| McCourt MP et al. | X-ray crystal structure of cytotoxic oxidized cholesterols: 7-ketocholesterol and 25-hydroxycholesterol. | 1997 | J. Lipid Res. | pmid:9186918 |
| Lyons MA et al. | Rapid hepatic metabolism of 7-ketocholesterol in vivo: implications for dietary oxysterols. | 1999 | J. Lipid Res. | pmid:10508204 |
| Gaspari AA and Rietschel RL | Anti-inflammatory properties of an oxidized sterol. | 1985 | J. Invest. Dermatol. | pmid:3968446 |
| Mariutti LR et al. | Lipid and cholesterol oxidation in chicken meat are inhibited by sage but not by garlic. | 2011 | J. Food Sci. | pmid:22417489 |
| Diestel A et al. | Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage. | 2003 | J. Exp. Med. | pmid:14657223 |
| Terasaka N et al. | ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. | 2008 | J. Clin. Invest. | pmid:18924609 |
| Alkazemi D et al. | Oxysterol as a marker of atherogenic dyslipidemia in adolescence. | 2008 | J. Clin. Endocrinol. Metab. | pmid:18713821 |
| Anticoli S et al. | 7-ketocholesterol and 5,6-secosterol modulate differently the stress-activated mitogen-activated protein kinases (MAPKs) in liver cells. | 2010 | J. Cell. Physiol. | pmid:19937729 |
| Schrader C et al. | Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo. | 2012 | J. Cell. Mol. Med. | pmid:22304296 |
| Ingueneau C et al. | TRPC1 is regulated by caveolin-1 and is involved in oxidized LDL-induced apoptosis of vascular smooth muscle cells. | 2009 | J. Cell. Mol. Med. | pmid:20187291 |
| Sanda GM et al. | Oxidized LDL-Exposed Human Macrophages Display Increased MMP-9 Expression and Secretion Mediated by Endoplasmic Reticulum Stress. | 2017 | J. Cell. Biochem. | pmid:27341688 |
| Son Y et al. | Roles of 7-ketocholesterol on the homeostasis of intracellular cholesterol level. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22622234 |
| Kim WK et al. | Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells. | 2010 | J. Bone Miner. Res. | pmid:19839776 |
| Perales S et al. | Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia. | 2009 | J. Biomed. Biotechnol. | pmid:19727411 |
| Han J et al. | Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I. | 2001 | J. Biol. Chem. | pmid:11278882 |
| Kimura T et al. | Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. | 2001 | J. Biol. Chem. | pmid:11427538 |