7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Noguchi N | Role of oxidative stress in adaptive responses in special reference to atherogenesis. | 2008 | J Clin Biochem Nutr | pmid:19015746 |
| Niki E | Do free radicals play causal role in atherosclerosis? Low density lipoprotein oxidation and vitamin E revisited. | 2011 | J Clin Biochem Nutr | pmid:21297905 |
| Raith K et al. | A new LC/APCI-MS method for the determination of cholesterol oxidation products in food. | 2005 | J Chromatogr A | pmid:15844526 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Shui G et al. | Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: applications to a rabbit model for atherosclerosis. | 2011 | J Chromatogr A | pmid:21621788 |
| Zunin P et al. | Sterol oxidation in meat- and fish-based homogenized baby foods containing vegetable oils. | 2006 Mar-Apr | J AOAC Int | pmid:16640291 |
| Luthra S et al. | Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17122150 |
| Rodriguez IR et al. | Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol. | 2004 | Invest. Ophthalmol. Vis. Sci. | pmid:15277510 |
| Wu M et al. | Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22678501 |
| Moreira EF et al. | 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:18936140 |
| Gramajo AL et al. | Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19834037 |
| Larrayoz IM et al. | 7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20554621 |
| Shi G et al. | Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:25678688 |
| Neekhra A et al. | Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17325185 |
| Butterfield DA et al. | Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. | 2012 | Int. J. Neuropsychopharmacol. | pmid:21767440 |
| Kiss L et al. | Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function. | 2006 | Int. J. Mol. Med. | pmid:17089016 |
| Lyons MA and Brown AJ | 7-Ketocholesterol. | 1999 Mar-Apr | Int. J. Biochem. Cell Biol. | pmid:10224662 |
| Kahn E et al. | Iron nanoparticles increase 7-ketocholesterol-induced cell death, inflammation, and oxidation on murine cardiac HL1-NB cells. | 2010 | Int J Nanomedicine | pmid:20463934 |
| Chien JT et al. | Integral kinetic model for studying quercetin degradation and oxidation as affected by cholesterol during heating. | 2010 | Int J Mol Sci | pmid:21152275 |
| Badreddine A et al. | Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N. | 2017 | Int J Mol Sci | pmid:29065513 |
| Islam MO et al. | Generation and characterization of a novel recombinant antibody against 15-ketocholestane isolated by phage-display. | 2012 | Int J Mol Sci | pmid:22606021 |
| Debbabi M et al. | Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells. | 2016 | Int J Mol Sci | pmid:27897980 |
| Csallany AS et al. | Protection of superoxide-induced cholesterol oxidation by antioxidants in protic conditions. | 2002 | Int J Food Sci Nutr | pmid:12396465 |
| Chalubinski M et al. | The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers. | 2013 | Inflamm. Res. | pmid:24077843 |
| Sharma A et al. | Effects of hydroquinone on retinal and vascular cells in vitro. | 2012 May-Jun | Indian J Ophthalmol | pmid:22569379 |
| Kasperczyk S et al. | Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead. | 2005 | Hum Exp Toxicol | pmid:16004195 |
| Wang M et al. | Plasma 7-ketocholesterol levels and the risk of incident cardiovascular events. | 2017 | Heart | pmid:28490621 |
| Farrell GC et al. | NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | 2012 | Gut Liver | pmid:22570745 |
| Sudo R et al. | 7-Ketocholesterol-induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress. | 2015 | Genes Cells | pmid:26419830 |
| Wyrwoll CS et al. | 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. | 2011 | Front Neuroendocrinol | pmid:21144857 |
| Harder T | The T Cell Plasma Membrane Lipid Bilayer Stages TCR-proximal Signaling Events. | 2012 | Front Immunol | pmid:22566932 |
| Pinchuk I and Lichtenberg D | Continuous monitoring of intermediates and final products of oxidation of low density lipoprotein by means of UV-spectroscopy. | 1996 | Free Radic. Res. | pmid:8733939 |
| Erridge C et al. | 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages. | 2007 | Free Radic. Res. | pmid:17364953 |
| Yoshioka N et al. | Oxysterols increase in diabetic rats. | 2005 | Free Radic. Res. | pmid:15788234 |
| Kinumi T et al. | Proteomic characterization of oxidative dysfunction in human umbilical vein endothelial cells (HUVEC) induced by exposure to oxidized LDL. | 2005 | Free Radic. Res. | pmid:16298863 |
| Rosa A et al. | Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA. | 2005 | Free Radic. Res. | pmid:16298741 |
| Sevanian A et al. | Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry. | 1994 | Free Radic. Biol. Med. | pmid:7835746 |
| Palozza P et al. | Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages. | 2007 | Free Radic. Biol. Med. | pmid:17448905 |
| Rimner A et al. | Relevance and mechanism of oxysterol stereospecifity in coronary artery disease. | 2005 | Free Radic. Biol. Med. | pmid:15649656 |
| Mascia C et al. | Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate. | 2010 | Free Radic. Biol. Med. | pmid:20923702 |
| Lizard G et al. | Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis. | 2000 | Free Radic. Biol. Med. | pmid:10754270 |
| Musman J et al. | Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. | 2016 | Free Radic. Biol. Med. | pmid:27989751 |
| Lee CY et al. | Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. | 2008 | Free Radic. Biol. Med. | pmid:18226605 |
| Seet RC et al. | Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? | 2011 | Free Radic. Biol. Med. | pmid:21420490 |
| Arca M et al. | Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy. | 2007 | Free Radic. Biol. Med. | pmid:17291993 |
| Larsson H et al. | In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress. | 2007 | Free Radic. Biol. Med. | pmid:17664133 |
| Kathir K et al. | Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and nondiabetic subjects. | 2010 | Free Radic. Biol. Med. | pmid:20478379 |
| Steffen Y et al. | Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio. | 2006 | Free Radic. Biol. Med. | pmid:16962939 |
| Li W et al. | Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependent. | 2012 | Free Radic. Biol. Med. | pmid:22985798 |
| Fu X et al. | 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144. | 2014 | Free Radic. Biol. Med. | pmid:24642088 |