7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gesquière L et al. | Impaired cellular cholesterol efflux by oxysterol-enriched high density lipoproteins. | 1997 | Free Radic. Biol. Med. | pmid:9215799 |
| Stanley N et al. | Concentrations of iron correlate with the extent of protein, but not lipid, oxidation in advanced human atherosclerotic lesions. | 2006 | Free Radic. Biol. Med. | pmid:16632123 |
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Palozza P et al. | Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages. | 2007 | Free Radic. Biol. Med. | pmid:17448905 |
| Deiana M et al. | Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. | 2017 | Free Radic. Biol. Med. | pmid:29102636 |
| Lizard G et al. | Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis. | 2000 | Free Radic. Biol. Med. | pmid:10754270 |
| Kathir K et al. | Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and nondiabetic subjects. | 2010 | Free Radic. Biol. Med. | pmid:20478379 |
| Guina T et al. | The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics. | 2015 | Food Funct | pmid:25736858 |
| Alemany L et al. | Evaluation of the cytotoxic effect of 7keto-stigmasterol and 7keto-cholesterol in human intestinal (Caco-2) cells. | 2012 | Food Chem. Toxicol. | pmid:22750387 |
| Alemany L et al. | Relative expression of cholesterol transport-related proteins and inflammation markers through the induction of 7-ketosterol-mediated stress in Caco-2 cells. | 2013 | Food Chem. Toxicol. | pmid:23454145 |
| Deiana M et al. | Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H(2)O(2) induced lipid peroxidation in renal tubular epithelial cells. | 2008 | Food Chem. Toxicol. | pmid:18588937 |
| Chalubinski M et al. | The effect of oxidized cholesterol on barrier functions and IL-10 mRNA expression in human intestinal epithelium co-cultured with dendritic cells in the transwell system. | 2014 | Food Chem. Toxicol. | pmid:24727230 |
| Deiana M et al. | Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells. | 2010 | Food Chem. Toxicol. | pmid:20691238 |
| Chung ML et al. | Profiling of oxidized lipid products of marine fish under acute oxidative stress. | 2013 | Food Chem. Toxicol. | pmid:23220612 |
| Cheng YW et al. | Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation. | 2005 | Food Chem. Toxicol. | pmid:15721210 |
| Clariana M and GarcÃa-Regueiro JA | Effect of high pressure processing on cholesterol oxidation products in vacuum packaged sliced dry-cured ham. | 2011 | Food Chem. Toxicol. | pmid:21426921 |
| Laparra JM et al. | 7keto-stigmasterol and 7keto-cholesterol induce differential proteome changes to intestinal epitelial (Caco-2) cells. | 2015 | Food Chem. Toxicol. | pmid:26140950 |
| Deiana M et al. | Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetate. | 2007 | Food Chem. Toxicol. | pmid:17686562 |
| Yue Q et al. | 7-ketocholesterol-induced caspase-mediated apoptosis in Saccharomyces cerevisiae. | 2013 | FEMS Yeast Res. | pmid:24028627 |
| Harada K et al. | Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway. | 1997 | FEBS Lett. | pmid:9247143 |
| Zarev S et al. | Major differences in oxysterol formation in human low density lipoproteins (LDLs) oxidized by *OH/O2*- free radicals or by copper. | 1999 | FEBS Lett. | pmid:10371147 |
| Lizard G et al. | Induction of apoptosis and of interleukin-1beta secretion by 7beta-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression. | 1997 | FEBS Lett. | pmid:9428650 |
| Lemaire S et al. | Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol. | 1998 | FEBS Lett. | pmid:9872417 |
| Pirillo A et al. | Oxysterols from oxidized LDL are cytotoxic but fail to induce hsp70 expression in endothelial cells. | 1999 | FEBS Lett. | pmid:10580102 |
| Yoshida T et al. | Cholestan-3beta,5alpha,6beta-triol, but not 7-ketocholesterol, suppresses taurocholate-induced mucin secretion by cultured dog gallbladder epithelial cells. | 2000 | FEBS Lett. | pmid:10922480 |
| Phan HT et al. | Localization of amyloid beta (Aβ1-42) protofibrils in membrane lateral compartments: effect of cholesterol and 7-Ketocholesterol. | 2014 | FEBS Lett. | pmid:25131929 |
| Khokhlov AN et al. | Effects of cholesterol- or 7-ketocholesterol-containing liposomes on colony-forming ability of cultured cells. | 1991 | FEBS Lett. | pmid:1915871 |
| Beriozov AT et al. | Cholesterol oxidation on fluorocarbon emulsion surface leads to the formation of 7-peroxycholesterol. | 1990 | FEBS Lett. | pmid:2365071 |
| Berthier A et al. | 7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways. | 2005 | FEBS J. | pmid:15955068 |
| Lizard G et al. | Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production. | 1998 | FASEB J. | pmid:9837855 |
| Gaus K et al. | Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. | 2004 | FASEB J. | pmid:14734645 |
| Biasi F et al. | Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation. | 2004 | FASEB J. | pmid:14977888 |
| Zocche Soprana H et al. | Cellular prion protein (PrP(C)) and superoxide dismutase (SOD) in vascular cells under oxidative stress. | 2011 | Exp. Toxicol. Pathol. | pmid:20060694 |
| Miah S et al. | Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. | 2013 | Exp. Toxicol. Pathol. | pmid:22999639 |
| Kim JW et al. | Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro. | 2002 | Exp. Mol. Med. | pmid:12085989 |
| Gregorio-King CC et al. | Effect of oxysterols on hematopoietic progenitor cells. | 2002 | Exp. Hematol. | pmid:12135663 |
| Lee JW et al. | Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina. | 2006 | Exp. Eye Res. | pmid:16549062 |
| Rodriguez IR et al. | 7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusen. | 2014 | Exp. Eye Res. | pmid:25261634 |
| Pascual I et al. | Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage. | 2010 | Exp. Eye Res. | pmid:20026324 |
| Palladini G et al. | Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635497 |
| Palladini G et al. | Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635498 |
| Girão H et al. | Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases. | 2003 | Exp. Cell Res. | pmid:14644170 |
| Naito Y et al. | Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species. | 2006 | Eur. J. Pharmacol. | pmid:16919261 |
| Perségol L et al. | Co-incubation of native and oxidized low-density lipoproteins: potentiation of relaxation impairment. | 2000 | Eur. J. Pharmacol. | pmid:11040350 |
| Uemura M et al. | Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation. | 2002 | Eur. J. Pharmacol. | pmid:12450566 |
| Lee DH et al. | Rotundarpene attenuates cholesterol oxidation product-induced apoptosis by suppressing the mitochondrial pathway and the caspase-8- and bid-dependent pathways. | 2015 | Eur. J. Pharmacol. | pmid:25592323 |
| Napolitano M and Bravo E | Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages. | 2005 | Eur. J. Clin. Invest. | pmid:16101668 |
| Breuer O et al. | Cholesterol 7 alpha-hydroxylase is up-regulated by the competitive inhibitor 7-oxocholesterol in rat liver. | 1993 | Eur. J. Biochem. | pmid:8354276 |
| Van Cantfort J and Gielen J | Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro. | 1975 | Eur. J. Biochem. | pmid:1175606 |
| Dugas B et al. | Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol. | 2010 | Eur J Nutr | pmid:20339855 |