7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xu G et al. | Oxidation of cholesterol and beta-sitosterol and prevention by natural antioxidants. | 2009 | J. Agric. Food Chem. | pmid:19754120 |
| Harder T and Sangani D | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. | 2009 | Cell Commun. Signal | pmid:19732448 |
| Perales S et al. | Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia. | 2009 | J. Biomed. Biotechnol. | pmid:19727411 |
| Hitsumoto T et al. | Clinical significance of serum 7-ketocholesterol concentrations in the progression of coronary atherosclerosis. | 2009 | J. Atheroscler. Thromb. | pmid:19672027 |
| Haider N et al. | Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis. | 2009 Sep-Oct | J Nucl Cardiol | pmid:19662466 |
| Loru D et al. | Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells. | 2009 May-Jun | Toxicol Ind Health | pmid:19651801 |
| Iuliano L et al. | Association of cholesterol oxidation and abnormalities in fatty acid metabolism in cystic fibrosis. | 2009 | Am. J. Clin. Nutr. | pmid:19587087 |
| Matsunaga I et al. | Determination of oxysterols in oxidatively modified low-density lipoprotein by semi-micro high-performance liquid chromatography with electrochemical detection. | 2009 | Anal. Biochem. | pmid:19563770 |
| Lee WH et al. | 7-ketocholesterol induces endoplasmic reticulum stress in HT-29 cells. | 2009 Mar-Apr | Z. Naturforsch., C, J. Biosci. | pmid:19526729 |
| Rodriguez IR and Fliesler SJ | Photodamage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism. | 2009 Sep-Oct | Photochem. Photobiol. | pmid:19500292 |
| Liu J et al. | Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol. | 2009 | Arch. Biochem. Biophys. | pmid:19464253 |
| Mazalli MR and Bragagnolo N | Increase of cholesterol oxidation and decrease of PUFA as a result of thermal processing and storage in eggs enriched with n-3 fatty acids. | 2009 | J. Agric. Food Chem. | pmid:19438228 |
| He X et al. | Apolipoprotein D modulates F2-isoprostane and 7-ketocholesterol formation and has a neuroprotective effect on organotypic hippocampal cultures after kainate-induced excitotoxic injury. | 2009 | Neurosci. Lett. | pmid:19429117 |
| Javitt NB and Javitt JC | The retinal oxysterol pathway: a unifying hypothesis for the cause of age-related macular degeneration. | 2009 | Curr Opin Ophthalmol | pmid:19390436 |
| Mathieu JM et al. | Medical bioremediation of age-related diseases. | 2009 | Microb. Cell Fact. | pmid:19358742 |
| Royer MC et al. | 7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death. | 2009 | J. Biol. Chem. | pmid:19351882 |
| Thewke D et al. | AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19338772 |
| Soejima S et al. | Hyperthermic sensitivity and cholesterol levels of mammalian cell lines in culture. | 1991 | Cancer Lett. | pmid:1933839 |
| Pilotelle-Bunner A et al. | The local electric field within phospholipid membranes modulates the charge transfer reactions in reaction centres. | 2009 | Biochim. Biophys. Acta | pmid:19306840 |
| German JB et al. | A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk. | 2009 | Eur J Nutr | pmid:19259609 |
| Brown AJ and Jessup W | Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis. | 2009 | Mol. Aspects Med. | pmid:19248801 |
| Hynynen R et al. | OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. | 2009 | J. Lipid Res. | pmid:19224871 |
| Kim DE et al. | Glycyrrhizin prevents 7-ketocholesterol toxicity against differentiated PC12 cells by suppressing mitochondrial membrane permeability change. | 2009 | Neurochem. Res. | pmid:19224363 |
| Khokhlov AN et al. | Effects of cholesterol- or 7-ketocholesterol-containing liposomes on colony-forming ability of cultured cells. | 1991 | FEBS Lett. | pmid:1915871 |
| Palozza P et al. | Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. | 2010 | J. Nutr. Biochem. | pmid:19157829 |
| Kell DB | Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. | 2009 | BMC Med Genomics | pmid:19133145 |
| Kuehnle K et al. | Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. | 2009 | Neurochem. Res. | pmid:19115107 |
| Sanson M et al. | Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. | 2009 | Circ. Res. | pmid:19106412 |
| Noguchi N | Role of oxidative stress in adaptive responses in special reference to atherogenesis. | 2008 | J Clin Biochem Nutr | pmid:19015746 |
| Balázs Z et al. | Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1. | 2009 | Mol. Cell. Endocrinol. | pmid:19010388 |
| Moreira EF et al. | 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:18936140 |
| Terasaka N et al. | ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. | 2008 | J. Clin. Invest. | pmid:18924609 |
| Sankaranarayanan S et al. | Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. | 2009 | J. Lipid Res. | pmid:18827283 |
| Kratzer A et al. | Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia. | 2009 | J. Lipid Res. | pmid:18812595 |
| Wamil M et al. | 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type. | 2008 | Endocrinology | pmid:18755798 |
| Vejux A et al. | Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis. | 2008 | Braz. J. Med. Biol. Res. | pmid:18719735 |
| Alkazemi D et al. | Oxysterol as a marker of atherogenic dyslipidemia in adolescence. | 2008 | J. Clin. Endocrinol. Metab. | pmid:18713821 |
| Borlak J and Jenke HS | Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation. | 2008 | Mol. Cancer Res. | pmid:18708364 |
| Freeman-Anderson NE et al. | Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis. | 2008 | J. Lipid Res. | pmid:18614816 |
| Saito E et al. | 7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells. | 2008 | J. Atheroscler. Thromb. | pmid:18603819 |
| Deiana M et al. | Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H(2)O(2) induced lipid peroxidation in renal tubular epithelial cells. | 2008 | Food Chem. Toxicol. | pmid:18588937 |
| Sung SC et al. | 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells. | 2009 | J. Vasc. Res. | pmid:18515973 |
| Rentero C et al. | Functional implications of plasma membrane condensation for T cell activation. | 2008 | PLoS ONE | pmid:18509459 |
| Rosa A et al. | Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation. | 2008 | Chem. Phys. Lipids | pmid:18498764 |
| Vejux A et al. | Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis. | 2009 | J. Nutr. Biochem. | pmid:18495460 |
| Martinet W et al. | Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells. | 2008 | Br. J. Pharmacol. | pmid:18469840 |
| Soustelle L et al. | UV laser mediated cell selective destruction by confocal microscopy. | 2008 | Neural Dev | pmid:18442390 |
| Rosa A et al. | Protective effect of vanilloids against tert-butyl hydroperoxide-induced oxidative stress in vero cells culture. | 2008 | J. Agric. Food Chem. | pmid:18439017 |
| Kim DH and Frangos JA | Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols. | 2008 | Biophys. J. | pmid:18390616 |
| Mathieu J et al. | Microbial degradation of 7-ketocholesterol. | 2008 | Biodegradation | pmid:18344006 |