7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Saitoh E et al. | [Variance of expressions of extracellular matrix components and effects of anti-osteoporotic drugs on Mönckeberg's arteriosclerosis]. | 2008 | Yakugaku Zasshi | pmid:18311057 |
| Bach D et al. | Interaction of 7-ketocholesterol with two major components of the inner leaflet of the plasma membrane: phosphatidylethanolamine and phosphatidylserine. | 2008 | Biochemistry | pmid:18247524 |
| Hans CP et al. | Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability. | 2008 | Cardiovasc. Res. | pmid:18245064 |
| Romeo GR and Kazlauskas A | Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. | 2008 | J. Biol. Chem. | pmid:18230613 |
| Lee CY et al. | Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. | 2008 | Free Radic. Biol. Med. | pmid:18226605 |
| Guo Z et al. | Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. | 2008 | Free Radic. Biol. Med. | pmid:18215741 |
| Mizukami M et al. | Proteome profiling of embryo chick retina. | 2008 | Proteome Sci | pmid:18208622 |
| Endo K et al. | Determination of serum 7-ketocholesterol concentrations and their relationships with coronary multiple risks in diabetes mellitus. | 2008 | Diabetes Res. Clin. Pract. | pmid:18207277 |
| Luthra S et al. | 7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro. | 2008 | Microvasc. Res. | pmid:18068200 |
| Fülöp T et al. | Immunosupportive therapies in aging. | 2007 | Clin Interv Aging | pmid:18044074 |
| Palozza P et al. | The protective role of carotenoids against 7-keto-cholesterol formation in solution. | 2008 | Mol. Cell. Biochem. | pmid:18008144 |
| Farooqui AA et al. | Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans. | 2007 | Brain Res Rev | pmid:17959252 |
| Gerry AB et al. | A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein. | 2008 | Atherosclerosis | pmid:17945239 |
| Lahoua Z et al. | Oxysterol activation of arachidonic acid release and prostaglandin E2 biosynthesis in NRK 49F cells is partially dependent on protein kinase C activity [corrected]. | 1991 | Cell. Signal. | pmid:1786206 |
| Terasaka N et al. | High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17846428 |
| Cox RH and Spencer EY | The Effect of 7-Ketocholesterol on the Rabbit. | 1949 | Science | pmid:17753811 |
| Myoishi M et al. | Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. | 2007 | Circulation | pmid:17709641 |
| Rittmann BE and Schloendorn J | Engineering away lysosomal junk: medical bioremediation. | 2007 | Rejuvenation Res | pmid:17708688 |
| Deiana M et al. | Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetate. | 2007 | Food Chem. Toxicol. | pmid:17686562 |
| Larsson H et al. | In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress. | 2007 | Free Radic. Biol. Med. | pmid:17664133 |
| Nashev LG et al. | Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. | 2007 | PLoS ONE | pmid:17593962 |
| Bravo E and Napolitano M | Mechanisms involved in chylomicron remnant lipid uptake by macrophages. | 2007 | Biochem. Soc. Trans. | pmid:17511627 |
| Javitt NB | Oxysterols: functional significance in fetal development and the maintenance of normal retinal function. | 2007 | Curr. Opin. Lipidol. | pmid:17495602 |
| Saldanha T and Bragagnolo N | Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi). | 2007 | Lipids | pmid:17492472 |
| Vejux A et al. | Effects of caspase inhibitors (z-VAD-fmk, z-VDVAD-fmk) on Nile Red fluorescence pattern in 7-ketocholesterol-treated cells: investigation by flow cytometry and spectral imaging microscopy. | 2007 | Cytometry A | pmid:17458884 |
| Joffre C et al. | Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. | 2007 | Curr. Eye Res. | pmid:17453947 |
| Palozza P et al. | Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages. | 2007 | Free Radic. Biol. Med. | pmid:17448905 |
| Wen Y and Leake DS | Low density lipoprotein undergoes oxidation within lysosomes in cells. | 2007 | Circ. Res. | pmid:17446432 |
| Erridge C et al. | 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages. | 2007 | Free Radic. Res. | pmid:17364953 |
| Mazalli MR and Bragagnolo N | Effect of storage on cholesterol oxide formation and fatty acid alterations in egg powder. | 2007 | J. Agric. Food Chem. | pmid:17348676 |
| Fuda H et al. | Oxysterols are substrates for cholesterol sulfotransferase. | 2007 | J. Lipid Res. | pmid:17347498 |
| Neekhra A et al. | Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17325185 |
| Sasaki H et al. | Vascular smooth muscle cell apoptosis induced by 7-ketocholesterol was mediated via Ca2+ and inhibited by the calcium channel blocker nifedipine. | 2007 | Metab. Clin. Exp. | pmid:17292724 |
| Arca M et al. | Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy. | 2007 | Free Radic. Biol. Med. | pmid:17291993 |
| Han JH et al. | Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition. | 2007 | Brain Res. | pmid:17224136 |
| Kahn E et al. | Flow cytometry and spectral imaging multiphoton microscopy analysis of CD36 expression with quantum dots 605 of untreated and 7-ketocholesterol-treated human monocytic cells. | 2006 | Anal. Quant. Cytol. Histol. | pmid:17220145 |
| Jiang X et al. | Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17154356 |
| Lee CS et al. | Differential modulation of 7-ketocholesterol toxicity against PC12 cells by calmodulin antagonists and Ca2+ channel blockers. | 2007 | Neurochem. Res. | pmid:17151911 |
| Ohtsuka M et al. | Lipids deposited in human atheromatous lesions induce apoptosis of human vascular smooth muscle cells. | 2006 | J. Atheroscler. Thromb. | pmid:17146154 |
| Luthra S et al. | Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17122150 |
| Kiss L et al. | Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function. | 2006 | Int. J. Mol. Med. | pmid:17089016 |
| Nakagawa K et al. | Protective effect of daidzein against acute ethanol-induced lipid peroxidation in rat jejunum. | 2006 | Kobe J Med Sci | pmid:17006054 |
| Dushkin MI et al. | Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages. | 2006 | Bull. Exp. Biol. Med. | pmid:16984105 |
| Hall MC | The effect of oxysterols, individually and as a representative mixture from food, on in vitro cultured bovine ovarian granulosa cells. | 2006 | Mol. Cell. Biochem. | pmid:16983501 |
| Steffen Y et al. | Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio. | 2006 | Free Radic. Biol. Med. | pmid:16962939 |
| Piga R et al. | Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants. | 2007 | Neurotoxicology | pmid:16942797 |
| Larsson DA et al. | Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. | 2006 | Free Radic. Biol. Med. | pmid:16934673 |
| Naito Y et al. | Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species. | 2006 | Eur. J. Pharmacol. | pmid:16919261 |
| Vitha MF and Clarke RJ | Comparison of excitation and emission ratiometric fluorescence methods for quantifying the membrane dipole potential. | 2007 | Biochim. Biophys. Acta | pmid:16904627 |
| Staprans I et al. | Ezetimibe inhibits the incorporation of dietary oxidized cholesterol into lipoproteins. | 2006 | J. Lipid Res. | pmid:16894239 |