7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brown AJ and Jessup W | Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis. | 2009 | Mol. Aspects Med. | pmid:19248801 |
| German JB et al. | A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk. | 2009 | Eur J Nutr | pmid:19259609 |
| Pilotelle-Bunner A et al. | The local electric field within phospholipid membranes modulates the charge transfer reactions in reaction centres. | 2009 | Biochim. Biophys. Acta | pmid:19306840 |
| Soejima S et al. | Hyperthermic sensitivity and cholesterol levels of mammalian cell lines in culture. | 1991 | Cancer Lett. | pmid:1933839 |
| Thewke D et al. | AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19338772 |
| Royer MC et al. | 7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death. | 2009 | J. Biol. Chem. | pmid:19351882 |
| Mathieu JM et al. | Medical bioremediation of age-related diseases. | 2009 | Microb. Cell Fact. | pmid:19358742 |
| Javitt NB and Javitt JC | The retinal oxysterol pathway: a unifying hypothesis for the cause of age-related macular degeneration. | 2009 | Curr Opin Ophthalmol | pmid:19390436 |
| He X et al. | Apolipoprotein D modulates F2-isoprostane and 7-ketocholesterol formation and has a neuroprotective effect on organotypic hippocampal cultures after kainate-induced excitotoxic injury. | 2009 | Neurosci. Lett. | pmid:19429117 |
| Mazalli MR and Bragagnolo N | Increase of cholesterol oxidation and decrease of PUFA as a result of thermal processing and storage in eggs enriched with n-3 fatty acids. | 2009 | J. Agric. Food Chem. | pmid:19438228 |
| Liu J et al. | Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol. | 2009 | Arch. Biochem. Biophys. | pmid:19464253 |
| Rodriguez IR and Fliesler SJ | Photodamage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism. | 2009 Sep-Oct | Photochem. Photobiol. | pmid:19500292 |
| Lee WH et al. | 7-ketocholesterol induces endoplasmic reticulum stress in HT-29 cells. | 2009 Mar-Apr | Z. Naturforsch., C, J. Biosci. | pmid:19526729 |
| Matsunaga I et al. | Determination of oxysterols in oxidatively modified low-density lipoprotein by semi-micro high-performance liquid chromatography with electrochemical detection. | 2009 | Anal. Biochem. | pmid:19563770 |
| Iuliano L et al. | Association of cholesterol oxidation and abnormalities in fatty acid metabolism in cystic fibrosis. | 2009 | Am. J. Clin. Nutr. | pmid:19587087 |
| Loru D et al. | Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells. | 2009 May-Jun | Toxicol Ind Health | pmid:19651801 |
| Haider N et al. | Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis. | 2009 Sep-Oct | J Nucl Cardiol | pmid:19662466 |
| Hitsumoto T et al. | Clinical significance of serum 7-ketocholesterol concentrations in the progression of coronary atherosclerosis. | 2009 | J. Atheroscler. Thromb. | pmid:19672027 |
| Perales S et al. | Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia. | 2009 | J. Biomed. Biotechnol. | pmid:19727411 |
| Harder T and Sangani D | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. | 2009 | Cell Commun. Signal | pmid:19732448 |
| Xu G et al. | Oxidation of cholesterol and beta-sitosterol and prevention by natural antioxidants. | 2009 | J. Agric. Food Chem. | pmid:19754120 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |
| Katsogiannou M et al. | Caveolae contribute to the apoptosis resistance induced by the alpha(1A)-adrenoceptor in androgen-independent prostate cancer cells. | 2009 | PLoS ONE | pmid:19763272 |
| Huang ZY et al. | [The apoptosis of mouse macrophage J774A.1 induced by oxysterol depend on NF-kappaB activation]. | 2009 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:19811731 |
| Gramajo AL et al. | Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19834037 |
| Kim WK et al. | Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells. | 2010 | J. Bone Miner. Res. | pmid:19839776 |
| Wielkoszyński T et al. | Concentration of anti-7-ketocholesterol antibodies in patient sera after heart transplantation. | 2009 | Transplant. Proc. | pmid:19857711 |
| Mathieu JM et al. | 7-ketocholesterol catabolism by Rhodococcus jostii RHA1. | 2010 | Appl. Environ. Microbiol. | pmid:19880645 |
| Anticoli S et al. | 7-ketocholesterol and 5,6-secosterol modulate differently the stress-activated mitogen-activated protein kinases (MAPKs) in liver cells. | 2010 | J. Cell. Physiol. | pmid:19937729 |
| Zabirnyk O et al. | Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. | 2010 | Carcinogenesis | pmid:19942609 |
| Kim YJ and Lee CS | Tyrosine kinase inhibitor AG126 reduces 7-ketocholesterol-induced cell death by suppressing mitochondria-mediated apoptotic process. | 2010 | Neurochem. Res. | pmid:19957203 |
| Seet RC et al. | Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. | 2010 | Free Radic. Biol. Med. | pmid:19969070 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Pascual I et al. | Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage. | 2010 | Exp. Eye Res. | pmid:20026324 |
| Schloendorn J et al. | Medical bioremediation: a concept moving toward reality. | 2009 | Rejuvenation Res | pmid:20041735 |
| Zocche Soprana H et al. | Cellular prion protein (PrP(C)) and superoxide dismutase (SOD) in vascular cells under oxidative stress. | 2011 | Exp. Toxicol. Pathol. | pmid:20060694 |
| Ong WY et al. | Changes in brain cholesterol metabolome after excitotoxicity. | 2010 | Mol. Neurobiol. | pmid:20140539 |
| Ingueneau C et al. | TRPC1 is regulated by caveolin-1 and is involved in oxidized LDL-induced apoptosis of vascular smooth muscle cells. | 2009 | J. Cell. Mol. Med. | pmid:20187291 |
| Hilario MC et al. | Feeding goats on scrubby Mexican rangeland and pasteurization: influences on milk and artisan cheese quality. | 2010 | Trop Anim Health Prod | pmid:20229357 |
| Jialal I et al. | Varying susceptibility of different low density lipoproteins to oxidative modification. | 1991 May-Jun | Arterioscler. Thromb. | pmid:2029490 |
| Dugas B et al. | Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol. | 2010 | Eur J Nutr | pmid:20339855 |
| Kim JS et al. | Cytoprotective effect of polysaccharide isolated from different mushrooms against 7-ketocholesterol induced damage in mouse liver cell line (BNL CL. 2). | 2007 | Nutr Res Pract | pmid:20368935 |
| Li D et al. | Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20395595 |
| Shentu TP et al. | oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20410437 |
| Suzuki K et al. | Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22. | 2010 | J. Periodont. Res. | pmid:20412422 |
| Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
| Klimenko OV et al. | Influence of the lung mechanical ventilation with injurious parameters on 7-ketocholesterol synthesis in Sus Scrofa. | 2010 | BMB Rep | pmid:20423610 |
| Huang Z et al. | 7-ketocholesterol induces cell apoptosis by activation of nuclear factor kappa B in mouse macrophages. | 2010 | Acta Med. Okayama | pmid:20424663 |
| Jarvie E et al. | Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. | 2010 | Clin. Sci. | pmid:20443782 |
| Kahn E et al. | Iron nanoparticles increase 7-ketocholesterol-induced cell death, inflammation, and oxidation on murine cardiac HL1-NB cells. | 2010 | Int J Nanomedicine | pmid:20463934 |