7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Owen DM et al. | High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells. | 2010 | Mol. Membr. Biol. | pmid:20540668 |
| Aye IL et al. | Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. | 2010 | Biochim. Biophys. Acta | pmid:20570635 |
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |
| Kim WK et al. | Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells. | 2010 | J. Bone Miner. Res. | pmid:19839776 |
| Chien JT et al. | Integral kinetic model for studying quercetin degradation and oxidation as affected by cholesterol during heating. | 2010 | Int J Mol Sci | pmid:21152275 |
| Shentu TP et al. | oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20410437 |
| Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
| Mascia C et al. | Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate. | 2010 | Free Radic. Biol. Med. | pmid:20923702 |
| Ong WY et al. | Changes in brain cholesterol metabolome after excitotoxicity. | 2010 | Mol. Neurobiol. | pmid:20140539 |
| Deiana M et al. | Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells. | 2010 | Food Chem. Toxicol. | pmid:20691238 |
| Wang Y et al. | Isolation and identification of two steroid compounds from Oviductus Ranae. | 2010 | Nat. Prod. Res. | pmid:20835952 |
| Janoszka B | 7-Ketocholesterol and 7-hydroxycholesterol in pork meat and its gravy thermally treated without additives and in the presence of onion and garlic. | 2010 | Meat Sci. | pmid:20822860 |
| RodrÃguez IR and Larrayoz IM | Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration. | 2010 | J. Lipid Res. | pmid:20567027 |
| Favero GM et al. | Synthetic nanoemulsion resembling a protein-free model of 7-ketocholesterol containing low density lipoprotein: In vitro and in vivo studies. | 2010 | Biol. Res. | pmid:21526270 |
| Liao PL et al. | 7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways. | 2010 | Toxicol. Lett. | pmid:20466046 |
| Seimon TA et al. | Induction of ER stress in macrophages of tuberculosis granulomas. | 2010 | PLoS ONE | pmid:20856677 |
| Zabirnyk O et al. | Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. | 2010 | Carcinogenesis | pmid:19942609 |
| Li D et al. | Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20395595 |
| Gramajo AL et al. | Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19834037 |
| Anticoli S et al. | 7-ketocholesterol and 5,6-secosterol modulate differently the stress-activated mitogen-activated protein kinases (MAPKs) in liver cells. | 2010 | J. Cell. Physiol. | pmid:19937729 |
| Kim YJ and Lee CS | Tyrosine kinase inhibitor AG126 reduces 7-ketocholesterol-induced cell death by suppressing mitochondria-mediated apoptotic process. | 2010 | Neurochem. Res. | pmid:19957203 |
| Seet RC et al. | Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. | 2010 | Free Radic. Biol. Med. | pmid:19969070 |
| Kathir K et al. | Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and nondiabetic subjects. | 2010 | Free Radic. Biol. Med. | pmid:20478379 |
| Suzuki K et al. | Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22. | 2010 | J. Periodont. Res. | pmid:20412422 |
| Kahn E et al. | Iron nanoparticles increase 7-ketocholesterol-induced cell death, inflammation, and oxidation on murine cardiac HL1-NB cells. | 2010 | Int J Nanomedicine | pmid:20463934 |
| Netherland C and Thewke DP | Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20609360 |
| Larrayoz IM et al. | 7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20554621 |
| Mintzer E et al. | Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes. | 2010 | Chem. Phys. Lipids | pmid:20471966 |
| Mathieu JM et al. | 7-ketocholesterol catabolism by Rhodococcus jostii RHA1. | 2010 | Appl. Environ. Microbiol. | pmid:19880645 |
| Jarvie E et al. | Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. | 2010 | Clin. Sci. | pmid:20443782 |
| Sharma A et al. | Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice. | 2010 | Libyan J Med | pmid:21483544 |
| Palozza P et al. | Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. | 2010 | J. Nutr. Biochem. | pmid:19157829 |
| Pascual I et al. | Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage. | 2010 | Exp. Eye Res. | pmid:20026324 |
| Ebrahimi KB and Handa JT | Lipids, lipoproteins, and age-related macular degeneration. | 2011 | J Lipids | pmid:21822496 |
| Magenau A et al. | Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. | 2011 | Traffic | pmid:21883764 |
| Palozza P et al. | Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. | 2011 | J. Nutr. Biochem. | pmid:20573495 |
| Flück CE et al. | Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia. | 2011 | PLoS ONE | pmid:21647419 |
| Seet RC et al. | Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? | 2011 | Free Radic. Biol. Med. | pmid:21420490 |
| Jang ER and Lee CS | 7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways. | 2011 | Neurochem. Int. | pmid:21035514 |
| Heo GY et al. | Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells. | 2011 | J. Lipid Res. | pmid:21411718 |
| Kahn E et al. | Impact of 7-ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: evaluation via LAURDAN and FAMIS spectral image analysis. | 2011 | Cytometry A | pmid:21381190 |
| Itabe H et al. | The Dynamics of Oxidized LDL during Atherogenesis. | 2011 | J Lipids | pmid:21660303 |
| Aye IL et al. | Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. | 2011 | Placenta | pmid:21208656 |
| Vestergaard MC et al. | The effect of oxycholesterols on thermo-induced membrane dynamics. | 2011 | Biochim. Biophys. Acta | pmid:21600872 |
| Le Lay S et al. | Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux. | 2011 | PLoS ONE | pmid:21858084 |
| Rosa A et al. | Protective role of arzanol against lipid peroxidation in biological systems. | 2011 | Chem. Phys. Lipids | pmid:20932961 |
| Deiana M et al. | Hydroxytyrosol glucuronides protect renal tubular epithelial cells against H(2)O(2) induced oxidative damage. | 2011 | Chem. Biol. Interact. | pmid:21798251 |
| Shinkyo R et al. | Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. | 2011 | J. Biol. Chem. | pmid:21813643 |
| Xu L et al. | Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. | 2011 | J. Lipid Res. | pmid:21817059 |