7-Ketocholesterol

7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.

Cross Reference

Introduction

To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 7-Ketocholesterol?

7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol

MeSH term MeSH ID Detail
Diabetic Retinopathy D003930 39 associated lipids
Arteriosclerosis D001161 86 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Carotid Stenosis D016893 15 associated lipids
Atherosclerosis D050197 85 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with 7-Ketocholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 7-Ketocholesterol?

Related references are published most in these journals:

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What functions are associated with 7-Ketocholesterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with 7-Ketocholesterol?

Related references are published most in these journals:

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What genes are associated with 7-Ketocholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 7-Ketocholesterol?

Knock-out

Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).

Mouse Model

Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 7-Ketocholesterol

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Authors Title Published Journal PubMed Link
Ghosh S et al. Cholesterol-oxidase-magnetic nanobioconjugates for the production of 4-cholesten-3-one and 4-cholesten-3, 7-dione. 2018 Bioresour. Technol. pmid:29413944
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Ghosh S and Khare SK Biodegradation of 7-Ketocholesterol by Rhodococcus erythropolis MTCC 3951: Process optimization and enzymatic insights. 2017 Chem. Phys. Lipids pmid:28571786
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Alba G et al. 7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils. 2016 Eur J Nutr pmid:26715521
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Chang MC et al. 7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells. 2016 Oncotarget pmid:27740938
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Debbabi M et al. Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells. 2016 Int J Mol Sci pmid:27897980
Ghosh S and Khare SK Biodegradation of cytotoxic 7-Ketocholesterol by Pseudomonas aeruginosa PseA. 2016 Bioresour. Technol. pmid:27020128
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Telesford DM et al. Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers. 2015 Langmuir pmid:26322794
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Chen Y et al. THP1 macrophages oxidized cholesterol, generating 7-derivative oxysterols specifically released by HDL. 2015 Steroids pmid:25742736
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Sudo R et al. 7-Ketocholesterol-induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress. 2015 Genes Cells pmid:26419830
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Indaram M et al. 7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration. 2015 Sci Rep pmid:25775051
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