7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Cox RH and Spencer EY | The Effect of 7-Ketocholesterol on the Rabbit. | 1949 | Science | pmid:17753811 |
| ROSENKRANTZ H and GUT M | Hydrogen bonding in 7-ketocholesterol and a new isomorph of 7-ketocholesteryl acetate. | 1954 | Science | pmid:13216220 |
| Van Cantfort J and Gielen J | Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro. | 1975 | Eur. J. Biochem. | pmid:1175606 |
| Pratt HP et al. | Membrane sterols and the development of the preimplantation mouse embryo. | 1980 | J Embryol Exp Morphol | pmid:7031162 |
| Smith LL et al. | Sterol metabolism--XLVII. Oxidized cholesterol esters in human tissues. | 1981 | J. Steroid Biochem. | pmid:7300357 |
| Williams JC et al. | Defective catabolism of low-density lipoprotein by fibroblasts from patients with I-cell disease. | 1982 | Biochem. J. | pmid:7082306 |
| Masuda A et al. | Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein. | 1982 | Mol. Cell. Biol. | pmid:7162516 |
| Saito H et al. | The regulating effect of cholesterol derivatives isolated from human sera on lymphocyte response to phytohemagglutinin. | 1983 | Tohoku J. Exp. Med. | pmid:6623455 |
| Slotte JP et al. | Uptake and esterification of exogenous cholesterol by low-density-lipoprotein-receptor-negative human fibroblasts in culture. | 1984 | Biochem. J. | pmid:6487273 |
| Heiniger HJ et al. | The role of cholesterol and its biosynthesis in lymphocyte proliferation and differentiation. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3868313 |
| Gaspari AA and Rietschel RL | Anti-inflammatory properties of an oxidized sterol. | 1985 | J. Invest. Dermatol. | pmid:3968446 |
| Jeng I et al. | Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. | 1985 | Biochem. Pharmacol. | pmid:3994747 |
| Murphy PR et al. | Binding of oxygenated cholesterol metabolites to antiestrogen binding sites from chicken liver. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3985957 |
| Ramachandran CK et al. | Enhancement in the adhesion of tumor cells to endothelial cells by decreased cholesterol synthesis. | 1986 | Cancer Res. | pmid:3697991 |
| Vargas RE et al. | Effect of dietary 7-ketocholesterol, pure, or oxidized cholesterol on hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity, energy balance, egg cholesterol concentration, and 14C-acetate incorporation into yolk lipids of laying hens. | 1986 | Poult. Sci. | pmid:3748946 |
| Beg ZH et al. | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone. | 1986 | Arch. Biochem. Biophys. | pmid:3004340 |
| Sevanian A and McLeod LL | Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase. | 1986 | J. Biol. Chem. | pmid:3941086 |
| Björkhem I | Assay of unesterified 7-oxocholesterol in human serum by isotope dilution-mass spectrometry. | 1986 | Anal. Biochem. | pmid:3524312 |
| Parish EJ et al. | A facile synthesis and carbon-13 nuclear magnetic resonance spectral properties of 7-ketocholesteryl benzoate. | 1987 | Lipids | pmid:3431349 |
| Prome D et al. | Conversion of sterols and triterpenes by mycobacteria. II. Transformation of 7-oxygenated sterols into androstane derivatives via a 7-deoxygenation. | 1987 | Biochim. Biophys. Acta | pmid:3663695 |
| Kosykh VA et al. | 7-ketocholesterol inhibits VLDL secretion by cultured human and rabbit hepatocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3390173 |
| Hwang PL | High-affinity binding sites for oxygenated sterols in rat liver microsomes: possible identity with antiestrogen binding sites. | 1990 | Biochim. Biophys. Acta | pmid:2306459 |
| Beriozov AT et al. | Cholesterol oxidation on fluorocarbon emulsion surface leads to the formation of 7-peroxycholesterol. | 1990 | FEBS Lett. | pmid:2365071 |
| Lahoua Z et al. | Oxysterol activation of arachidonic acid release and prostaglandin E2 biosynthesis in NRK 49F cells is partially dependent on protein kinase C activity [corrected]. | 1991 | Cell. Signal. | pmid:1786206 |
| Soejima S et al. | Hyperthermic sensitivity and cholesterol levels of mammalian cell lines in culture. | 1991 | Cancer Lett. | pmid:1933839 |
| Khokhlov AN et al. | Effects of cholesterol- or 7-ketocholesterol-containing liposomes on colony-forming ability of cultured cells. | 1991 | FEBS Lett. | pmid:1915871 |
| Jialal I et al. | Varying susceptibility of different low density lipoproteins to oxidative modification. | 1991 May-Jun | Arterioscler. Thromb. | pmid:2029490 |
| Tamasawa N and Takebe K | Analytical examination of oxidized free and esterified 7-ketocholesterol and related oxysterols in human plasma incubated with copper. | 1992 | Tohoku J. Exp. Med. | pmid:1488757 |
| Kupferberg A et al. | Separation and purification of dolichol and dolichyl phosphate by anion-exchange paper chromatography: application to cultured cells. | 1992 | Anal. Biochem. | pmid:1443591 |
| Dorset DL | Binary phase behavior of angiotoxic oxidized cholesterols with cholesterol. | 1992 | Biochim. Biophys. Acta | pmid:1511006 |
| Hwang PL | Inhibitors of protein and RNA synthesis block the cytotoxic effects of oxygenated sterols. | 1992 | Biochim. Biophys. Acta | pmid:1379472 |
| Breuer O et al. | Cholesterol 7 alpha-hydroxylase is up-regulated by the competitive inhibitor 7-oxocholesterol in rat liver. | 1993 | Eur. J. Biochem. | pmid:8354276 |
| Huggett CD et al. | Plasma VLDL cholesterol and egg cholesterol are resistant to change in the laying hen. | 1993 | Biochem. Soc. Trans. | pmid:8359401 |
| Hughes H et al. | Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. | 1994 | Arterioscler. Thromb. | pmid:8018675 |
| Sevanian A et al. | Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry. | 1994 | Free Radic. Biol. Med. | pmid:7835746 |
| Maor I and Aviram M | Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester. | 1994 | J. Lipid Res. | pmid:8071603 |
| Li QT and Das NP | Comparison of the effects of cholesterol and oxysterols on phospholipid bilayer microheterogeneity: a study of fluorescence lifetime distributions. | 1994 | Arch. Biochem. Biophys. | pmid:7986094 |
| Tamasawa N et al. | The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7 alpha-hydroxylase activity in rat. | 1994 | Biochim. Biophys. Acta | pmid:8068724 |
| Low YL and Hwang PL | Lymphoma cells selected for resistance against the cytotoxic effect of oxygenated sterols are also resistant to nonsteroidal antiestrogens. | 1995 | Biochim. Biophys. Acta | pmid:7578268 |
| Sugiyama S et al. | Lipoproteins regulate C-type natriuretic peptide secretion from cultured vascular endothelial cells. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7583578 |
| Guyton JR et al. | Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. | 1995 | Atherosclerosis | pmid:8770318 |
| Maor I et al. | Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7670952 |
| Axelson M et al. | Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. | 1995 | J. Lipid Res. | pmid:7751816 |
| Breuer O and Björkhem I | Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. | 1995 | J. Biol. Chem. | pmid:7657597 |
| Kritharides L et al. | Apolipoprotein A-I-mediated efflux of sterols from oxidized LDL-loaded macrophages. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7749836 |
| Song W et al. | Endogenous 7-oxocholesterol is an enzymatic product: characterization of 7 alpha-hydroxycholesterol dehydrogenase activity of hamster liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8645004 |
| Gelissen IC et al. | Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol. | 1996 | J. Biol. Chem. | pmid:8663356 |
| Palladini G et al. | Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635497 |
| Brown AJ et al. | Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages. | 1996 | J. Lipid Res. | pmid:9026530 |