7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ghosh S et al. | Cholesterol-oxidase-magnetic nanobioconjugates for the production of 4-cholesten-3-one and 4-cholesten-3, 7-dione. | 2018 | Bioresour. Technol. | pmid:29413944 |
| Tang HY et al. | Lipidomics reveals accumulation of the oxidized cholesterol in erythrocytes of heart failure patients. | 2018 | Redox Biol | pmid:29101899 |
| Cho HR et al. | 7-Oxygenated cholesterol molecules differentially affect the expression of zonula occludens-1 in vascular smooth muscle cells and monocyte/macrophage cells. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29428726 |
| Pyrshev KA et al. | Caspase-3 activation decreases lipid order in the outer plasma membrane leaflet during apoptosis: A fluorescent probe study. | 2017 | Biochim. Biophys. Acta | pmid:28784460 |
| Pang C et al. | Biotransformation of cholesterol and 16,17-alpha epoxypregnenolone by novel Cladosporium sp. strain IS547. | 2017 | J. Basic Microbiol. | pmid:27690325 |
| Cho HR et al. | 7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor. | 2017 | PLoS ONE | pmid:28323848 |
| Debbabi M et al. | Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells. | 2017 | Chem. Phys. Lipids | pmid:28408132 |
| Leoni V et al. | Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27020660 |
| Deiana M et al. | Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. | 2017 | Free Radic. Biol. Med. | pmid:29102636 |
| Badreddine A et al. | Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N. | 2017 | Int J Mol Sci | pmid:29065513 |
| Wnętrzak A et al. | Oxysterols Versus Cholesterol in Model Neuronal Membrane. I. The Case of 7-Ketocholesterol. The Langmuir Monolayer Study. | 2017 | J. Membr. Biol. | pmid:28861595 |
| Kim A et al. | Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-κB activation-mediated cell death. | 2017 | Brain Res. Bull. | pmid:28710022 |
| Zarrouk A et al. | Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26921765 |
| Ward LJ et al. | Exposure to atheroma-relevant 7-oxysterols causes proteomic alterations in cell death, cellular longevity, and lipid metabolism in THP-1 macrophages. | 2017 | PLoS ONE | pmid:28350877 |
| Koka S et al. | Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia. | 2017 | Redox Biol | pmid:28633109 |
| Rosa-Fernandes L et al. | Outside-in, inside-out: Proteomic analysis of endothelial stress mediated by 7-ketocholesterol. | 2017 | Chem. Phys. Lipids | pmid:28663071 |
| Wang Y et al. | Mitochondrial Oxidative Stress Promotes Atherosclerosis and Neutrophil Extracellular Traps in Aged Mice. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28596373 |
| Ghosh S and Khare SK | Biodegradation of 7-Ketocholesterol by Rhodococcus erythropolis MTCC 3951: Process optimization and enzymatic insights. | 2017 | Chem. Phys. Lipids | pmid:28571786 |
| Rosa Fernandes L et al. | 7-Ketocholesterol overcomes drug resistance in chronic myeloid leukemia cell lines beyond MDR1 mechanism. | 2017 | J Proteomics | pmid:27343758 |
| Wang M et al. | Plasma 7-ketocholesterol levels and the risk of incident cardiovascular events. | 2017 | Heart | pmid:28490621 |
| Song J et al. | Association of Plasma 7-Ketocholesterol With Cardiovascular Outcomes and Total Mortality in Patients With Coronary Artery Disease. | 2017 | Circ. Res. | pmid:28381400 |
| Sanda GM et al. | Oxidized LDL-Exposed Human Macrophages Display Increased MMP-9 Expression and Secretion Mediated by Endoplasmic Reticulum Stress. | 2017 | J. Cell. Biochem. | pmid:27341688 |
| Silva SF et al. | Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27133385 |
| Bezine M et al. | Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. | 2017 | Chem. Phys. Lipids | pmid:28322741 |
| Nury T et al. | 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27041118 |
| Musman J et al. | Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. | 2016 | Free Radic. Biol. Med. | pmid:27989751 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Rasmiena AA et al. | High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein. | 2016 | Biochim. Biophys. Acta | pmid:26569052 |
| Alba G et al. | 7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils. | 2016 | Eur J Nutr | pmid:26715521 |
| Tran J et al. | Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells. | 2016 | PLoS ONE | pmid:26977592 |
| Boenzi S et al. | Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism. | 2016 | J. Lipid Res. | pmid:26733147 |
| Gajewski A et al. | Helicobacter pylori antigens, acetylsalicylic acid, LDL and 7-ketocholesterol - their potential role in destabilizing the gastric epithelial cell barrier. An in vitro model of Kato III cells. | 2016 | Acta Biochim. Pol. | pmid:26619253 |
| Chang MC et al. | 7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells. | 2016 | Oncotarget | pmid:27740938 |
| Zhan X et al. | [Blood 7-ketocholesterol level, clinical features and gene mutation analysis of 18 children with Niemann-Pick disease type C]. | 2016 | Zhonghua Er Ke Za Zhi | pmid:27256227 |
| Debbabi M et al. | Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells. | 2016 | Int J Mol Sci | pmid:27897980 |
| Ghosh S and Khare SK | Biodegradation of cytotoxic 7-Ketocholesterol by Pseudomonas aeruginosa PseA. | 2016 | Bioresour. Technol. | pmid:27020128 |
| Romanello M et al. | Comprehensive Evaluation of Plasma 7-Ketocholesterol and Cholestan-3β,5α,6β-Triol in an Italian Cohort of Patients Affected by Niemann-Pick Disease due to NPC1 and SMPD1 Mutations. | 2016 | Clin. Chim. Acta | pmid:26790753 |
| Guina T et al. | The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics. | 2015 | Food Funct | pmid:25736858 |
| Telesford DM et al. | Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers. | 2015 | Langmuir | pmid:26322794 |
| Lee DH et al. | Quercetin-3-O-(2″-galloyl)-α-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-κB-mediated cell death process in differentiated PC12 cells. | 2015 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:25845326 |
| Sudo R et al. | 7-Ketocholesterol-induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress. | 2015 | Genes Cells | pmid:26419830 |
| Xu M et al. | Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene. | 2015 | Cell. Physiol. Biochem. | pmid:26315049 |
| Pajares S et al. | Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency. | 2015 | J. Lipid Res. | pmid:26239048 |
| Davis S et al. | α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein. | 2015 | J. Lipid Res. | pmid:26026069 |
| Moinard C et al. | Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats. | 2015 | J. Nutr. | pmid:26019250 |
| Indaram M et al. | 7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration. | 2015 | Sci Rep | pmid:25775051 |
| Shi G et al. | Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:25678688 |
| Laparra JM et al. | 7keto-stigmasterol and 7keto-cholesterol induce differential proteome changes to intestinal epitelial (Caco-2) cells. | 2015 | Food Chem. Toxicol. | pmid:26140950 |
| Klinke G et al. | LC-MS/MS based assay and reference intervals in children and adolescents for oxysterols elevated in Niemann-Pick diseases. | 2015 | Clin. Biochem. | pmid:25819840 |
| Odermatt A and Klusonova P | 11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25151952 |