7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chalubinski M et al. | The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers. | 2013 | Inflamm. Res. | pmid:24077843 |
| He C et al. | 7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B. | 2013 | Am. J. Pathol. | pmid:23770348 |
| Yue Q et al. | 7-ketocholesterol-induced caspase-mediated apoptosis in Saccharomyces cerevisiae. | 2013 | FEMS Yeast Res. | pmid:24028627 |
| Xu M et al. | Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. | 2013 | Biochim. Biophys. Acta | pmid:24095928 |
| Buttari B et al. | 7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophages. | 2013 | Biochem. Pharmacol. | pmid:23611834 |
| Okabe A et al. | Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death. | 2013 | Redox Biol | pmid:24371802 |
| Sharma A et al. | Effects of hydroquinone on retinal and vascular cells in vitro. | 2012 May-Jun | Indian J Ophthalmol | pmid:22569379 |
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| Alemany L et al. | Evaluation of the cytotoxic effect of 7keto-stigmasterol and 7keto-cholesterol in human intestinal (Caco-2) cells. | 2012 | Food Chem. Toxicol. | pmid:22750387 |
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| Islam MO et al. | Generation and characterization of a novel recombinant antibody against 15-ketocholestane isolated by phage-display. | 2012 | Int J Mol Sci | pmid:22606021 |
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| Farrell GC et al. | NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | 2012 | Gut Liver | pmid:22570745 |
| Harder T | The T Cell Plasma Membrane Lipid Bilayer Stages TCR-proximal Signaling Events. | 2012 | Front Immunol | pmid:22566932 |
| Shentu TP et al. | The role of oxysterols in control of endothelial stiffness. | 2012 | J. Lipid Res. | pmid:22496390 |
| Satchell L and Leake DS | Oxidation of low-density lipoprotein by iron at lysosomal pH: implications for atherosclerosis. | 2012 | Biochemistry | pmid:22493939 |
| Cheng AM et al. | Apolipoprotein A-I attenuates palmitate-mediated NF-κB activation by reducing Toll-like receptor-4 recruitment into lipid rafts. | 2012 | PLoS ONE | pmid:22479476 |
| Gui T et al. | Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery. | 2012 | Mediators Inflamm. | pmid:22577254 |
| Ketola K et al. | Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. | 2012 | Br. J. Cancer | pmid:22215106 |
| Katsuyama M et al. | Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. | 2012 | J Clin Biochem Nutr | pmid:22247596 |
| Son Y et al. | Roles of 7-ketocholesterol on the homeostasis of intracellular cholesterol level. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22622234 |
| Steffen Y et al. | Cigarette smoke and LDL cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both eNOS and NADPH oxidase. | 2012 | Nitric Oxide | pmid:22766265 |
| Rutherford LD and Gieseg SP | 7-ketocholesterol is not cytotoxic to U937 cells when incorporated into acetylated low density lipoprotein. | 2012 | Lipids | pmid:22124807 |
| Catarino S et al. | Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells. | 2012 | Acta Ophthalmol | pmid:22313893 |
| Li W et al. | Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependent. | 2012 | Free Radic. Biol. Med. | pmid:22985798 |
| Arciello M et al. | Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. | 2012 | Dig Liver Dis | pmid:22154950 |
| Matysik S et al. | Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. | 2012 | Clin. Chem. | pmid:22997279 |
| Lim L et al. | Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. | 2012 | Cell Death Differ. | pmid:21818119 |
| Huang JD et al. | Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization. | 2012 | Biochim. Biophys. Acta | pmid:22342272 |
| Ostrowska M et al. | Cerebrotendinous xanthomatosis: a rare cause of spinocerebellar syndrome. | 2011 Nov-Dec | Neurol. Neurochir. Pol. | pmid:22212991 |
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| Tian L et al. | Red and white wines inhibit cholesterol oxidation induced by free radicals. | 2011 | J. Agric. Food Chem. | pmid:21563753 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Mariutti LR et al. | Lipid and cholesterol oxidation in chicken meat are inhibited by sage but not by garlic. | 2011 | J. Food Sci. | pmid:22417489 |
| Wyrwoll CS et al. | 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. | 2011 | Front Neuroendocrinol | pmid:21144857 |
| Ebrahimi KB and Handa JT | Lipids, lipoproteins, and age-related macular degeneration. | 2011 | J Lipids | pmid:21822496 |
| Magenau A et al. | Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. | 2011 | Traffic | pmid:21883764 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| Palozza P et al. | Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. | 2011 | J. Nutr. Biochem. | pmid:20573495 |
| Flück CE et al. | Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia. | 2011 | PLoS ONE | pmid:21647419 |
| Shui G et al. | Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: applications to a rabbit model for atherosclerosis. | 2011 | J Chromatogr A | pmid:21621788 |
| Li W et al. | Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21621514 |
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| Jang ER and Lee CS | 7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways. | 2011 | Neurochem. Int. | pmid:21035514 |
| Heo GY et al. | Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells. | 2011 | J. Lipid Res. | pmid:21411718 |
| Kahn E et al. | Impact of 7-ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: evaluation via LAURDAN and FAMIS spectral image analysis. | 2011 | Cytometry A | pmid:21381190 |
| Jiang X et al. | A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. | 2011 | J. Lipid Res. | pmid:21518695 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
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| Aye IL et al. | Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. | 2011 | Placenta | pmid:21208656 |
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| Janoszka B | 7-Ketocholesterol and 7-hydroxycholesterol in pork meat and its gravy thermally treated without additives and in the presence of onion and garlic. | 2010 | Meat Sci. | pmid:20822860 |
| Favero GM et al. | Synthetic nanoemulsion resembling a protein-free model of 7-ketocholesterol containing low density lipoprotein: In vitro and in vivo studies. | 2010 | Biol. Res. | pmid:21526270 |
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| Mintzer E et al. | Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes. | 2010 | Chem. Phys. Lipids | pmid:20471966 |
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